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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_title" content="Clinical Review Report: Ticagrelor (Brilinta)" /><meta name="citation_publisher" content="Canadian Agency for Drugs and Technologies in Health" /><meta name="citation_date" content="2016/08" /><meta name="citation_pmid" content="30920786" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK539147/" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Clinical Review Report: Ticagrelor (Brilinta)" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="Canadian Agency for Drugs and Technologies in Health" /><meta name="DC.Date" content="2016/08" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK539147/" /><meta name="description" content="The objective was to perform a systematic review of the beneficial and harmful effects of ticagrelor 60 mg and 90 mg tablets co-administered with low-dose (75 mg to 150 mg) acetylsalicylic acid, for the prevention of atherothrombotic events in adult patients with a history of myocardial infarction that occurred at least one year ago, and a high risk of developing an atherothrombotic event." /><meta name="og:title" content="Clinical Review Report: Ticagrelor (Brilinta)" /><meta name="og:type" content="book" /><meta name="og:description" content="The objective was to perform a systematic review of the beneficial and harmful effects of ticagrelor 60 mg and 90 mg tablets co-administered with low-dose (75 mg to 150 mg) acetylsalicylic acid, for the prevention of atherothrombotic events in adult patients with a history of myocardial infarction that occurred at least one year ago, and a high risk of developing an atherothrombotic event." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK539147/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-srcl0474-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/srcl0474/toc/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK539147/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" media="print" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript" src="/corehtml/pmc/js/large-obj-scrollbars.min.js"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script><meta name="book-collection" content="cadthcdrcollect" />
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p></div><div class="pagination bk_noprnt"><span class="inactive page_link prev">< Prev</span><a class="active page_link next" href="/books/n/srcl0474/clabb/" title="Next page in this title">Next ></a></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/Book"><div class="meta-content fm-sec"><div class="iconblock whole_rhythm clearfix no_top_margin"><a href="http://www.cadth.ca/" title="Canadian Agency for Drugs and Technologies in Health" class="img_link icnblk_img" ref="pagearea=logo&targetsite=external&targetcat=link&targettype=publisher"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-srcl0474-lrg.png" alt="Cover of Clinical Review Report: Ticagrelor (Brilinta)" /></a><div class="icnblk_cntnt"><h1 id="_NBK539147_"><span itemprop="name">Clinical Review Report: Ticagrelor (Brilinta)</span></h1><p><i>CADTH Common Drug Review</i></p><div class="half_rhythm">Ottawa (ON): <a href="http://www.cadth.ca/" ref="pagearea=meta&targetsite=external&targetcat=link&targettype=publisher"><span itemprop="publisher">Canadian Agency for Drugs and Technologies in Health</span></a>; <span itemprop="datePublished">2016 Aug</span>.</div><div class="half_rhythm"><ul class="inline_list"><li><span class="label"><a data-jig="ncbidialog" href="#_ncbi_dlg_cpyrght_NBK539147" data-jigconfig="modal:true">Copyright and
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Permissions</a></span></li></ul></div><div id="_ncbi_dlg_cpyrght_NBK539147" style="display:none" title="Copyright and Permissions"><div><div>Copyright © 2016 Canadian Agency for Drugs and Technologies in Health.</div><div class="half_rhythm"><div>Except where otherwise noted, this work is distributed under the terms of a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International licence (CC BY-NC-ND), a copy of which is available at <a href="http://creativecommons.org/licenses/by-nc-nd/4.0/" ref="pagearea=meta&targetsite=external&targetcat=link&targettype=uri">http://creativecommons.org/licenses/by-nc-nd/4.0/</a></div><div>The copyright and other intellectual property rights in this document are owned by CADTH and its licensors. These rights are protected by the Canadian <i>Copyright Act</i> and other national and international laws and agreements. Users are permitted to make copies of this document for non-commercial purposes only, provided it is not modified when reproduced and appropriate credit is given to CADTH and its licensors.</div></div></div></div><div class="bk_noprnt"><form method="get" action="/books/n/srcl0474/" id="bk_srch"><div class="bk_search"><label for="bk_term" class="offscreen_noflow">Search term</label><input type="text" title="Search this book" id="bk_term" name="term" value="" data-jig="ncbiclearbutton" /> <input type="submit" class="jig-ncbibutton" value="Search this book" submit="false" style="padding: 0.1em 0.4em;" /></div></form></div></div></div></div><div class="body-content whole_rhythm" itemprop="text"><div itemprop="description"><p>The objective was to perform a systematic review of the beneficial and harmful effects of ticagrelor 60 mg and 90 mg tablets co-administered with low-dose (75 mg to 150 mg) acetylsalicylic acid, for the prevention of atherothrombotic events in adult patients with a history of myocardial infarction that occurred at least one year ago, and a high risk of developing an atherothrombotic event.</p><div id="srcl0474.tab1" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK539147/table/srcl0474.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__srcl0474.tab1_lrgtbl__"><table><tbody><tr><th id="hd_b_srcl0474.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Drug</th><td headers="hd_b_srcl0474.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Ticagrelor (Brilinta)</td></tr><tr><th id="hd_b_srcl0474.tab1_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Indication</th><td headers="hd_b_srcl0474.tab1_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Co-administered with low-dose acetylsalicylic acid (ASA: 75-150 mg), is indicated for the secondary prevention of atherothrombotic events in patients with a history of myocardial infarction (MI occurred at least one year ago) and a high risk of developing an atherothrombotic event.</td></tr><tr><th id="hd_b_srcl0474.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Listing request</th><td headers="hd_b_srcl0474.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Co-administered with low-dose acetylsalicylic acid (ASA: 75-150 mg), is indicated for the secondary prevention of atherothrombotic events in patients with a history of myocardial infarction (MI occurred at least one year ago) and a high risk of developing an atherothrombotic event</td></tr><tr><th id="hd_b_srcl0474.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Dosage form(s)</th><td headers="hd_b_srcl0474.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">60 mg tablets</td></tr><tr><th id="hd_b_srcl0474.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">NOC date</th><td headers="hd_b_srcl0474.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">May 30, 2016</td></tr><tr><th id="hd_b_srcl0474.tab1_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Manufacturer</th><td headers="hd_b_srcl0474.tab1_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">AstraZeneca Canada Inc.</td></tr></tbody></table></div></div></div><div><h2>Contents</h2><div class="bktoc_all_cntnr top align_right" style="display:none"><ul class="inline_list_right"><li><a class="bktoc_all_exp" href="#">Expand All</a></li><li style="margin-left:.8em"><a class="bktoc_all_clps" href="#">Collapse All</a></li></ul></div><ul id="toc_tllNBK539147_toc_clabb" class="simple-list toc toc-toggle"><li class="half_rhythm" id="toc_itm_NBK539147_toc_clabb"><a class="toc-item" href="/books/n/srcl0474/clabb/">Abbreviations</a></li><li class="half_rhythm" id="toc_itm_NBK539147_toc_cles"><a class="toc-item" href="/books/n/srcl0474/cles/">Executive Summary</a></li><li class="half_rhythm" id="toc_itm_NBK539147_toc_cl1"><a class="toc-item" href="/books/n/srcl0474/cl1/">1. Introduction</a><ul id="toc_lst_NBK539147_toc_cl1" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK539147_toc_cl1_s1"><a class="toc-item" href="/books/n/srcl0474/cl1/#cl1.s1">1.1. Disease prevalence and incidence</a></li><li class="half_rhythm" id="toc_itm_NBK539147_toc_cl1_s2"><a class="toc-item" href="/books/n/srcl0474/cl1/#cl1.s2">1.2. Standards of therapy</a></li><li class="half_rhythm" id="toc_itm_NBK539147_toc_cl1_s3"><a class="toc-item" href="/books/n/srcl0474/cl1/#cl1.s3">1.3. Drug</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK539147_toc_cl2"><a class="toc-item" href="/books/n/srcl0474/cl2/">2. Objectives and Methods</a><ul id="toc_lst_NBK539147_toc_cl2" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK539147_toc_cl2_s1"><a class="toc-item" href="/books/n/srcl0474/cl2/#cl2.s1">2.1. Objectives</a></li><li class="half_rhythm" id="toc_itm_NBK539147_toc_cl2_s2"><a class="toc-item" href="/books/n/srcl0474/cl2/#cl2.s2">2.2. Methods</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK539147_toc_cl3"><a class="toc-item" href="/books/n/srcl0474/cl3/">3. Results</a><ul id="toc_lst_NBK539147_toc_cl3" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK539147_toc_cl3_s1"><a class="toc-item" href="/books/n/srcl0474/cl3/#cl3.s1">3.1. Findings from the literature</a></li><li class="half_rhythm" id="toc_itm_NBK539147_toc_cl3_s2"><a class="toc-item" href="/books/n/srcl0474/cl3/#cl3.s2">3.2. Included studies</a></li><li class="half_rhythm" id="toc_itm_NBK539147_toc_cl3_s3"><a class="toc-item" href="/books/n/srcl0474/cl3/#cl3.s3">3.3. Patient disposition</a></li><li class="half_rhythm" id="toc_itm_NBK539147_toc_cl3_s4"><a class="toc-item" href="/books/n/srcl0474/cl3/#cl3.s4">3.4. Exposure to study treatments</a></li><li class="half_rhythm" id="toc_itm_NBK539147_toc_cl3_s5"><a class="toc-item" href="/books/n/srcl0474/cl3/#cl3.s5">3.5. Critical appraisal</a></li><li class="half_rhythm" id="toc_itm_NBK539147_toc_cl3_s6"><a class="toc-item" href="/books/n/srcl0474/cl3/#cl3.s6">3.6. Efficacy</a></li><li class="half_rhythm" id="toc_itm_NBK539147_toc_cl3_s7"><a class="toc-item" href="/books/n/srcl0474/cl3/#cl3.s7">3.7. Harms</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK539147_toc_cl4"><a class="toc-item" href="/books/n/srcl0474/cl4/">4. Discussion</a><ul id="toc_lst_NBK539147_toc_cl4" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK539147_toc_cl4_s1"><a class="toc-item" href="/books/n/srcl0474/cl4/#cl4.s1">4.1. Summary of available evidence</a></li><li class="half_rhythm" id="toc_itm_NBK539147_toc_cl4_s2"><a class="toc-item" href="/books/n/srcl0474/cl4/#cl4.s2">4.2. Interpretation of Results</a></li><li class="half_rhythm" id="toc_itm_NBK539147_toc_cl4_s3"><a class="toc-item" href="/books/n/srcl0474/cl4/#cl4.s3">4.3. Potential Place in Therapy</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK539147_toc_cl5"><a class="toc-item" href="/books/n/srcl0474/cl5/">5. Conclusions</a></li><li class="half_rhythm" id="toc_itm_NBK539147_toc_cl_app1"><a class="toc-item" href="/books/n/srcl0474/cl.app1/">APPENDIX 1. Patient Input Summary</a></li><li class="half_rhythm" id="toc_itm_NBK539147_toc_cl_app2"><a class="toc-item" href="/books/n/srcl0474/cl.app2/">APPENDIX 2. Literature Search Strategy</a></li><li class="half_rhythm" id="toc_itm_NBK539147_toc_cl_app3"><a class="toc-item" href="/books/n/srcl0474/cl.app3/">APPENDIX 3. Excluded Studies</a></li><li class="half_rhythm" id="toc_itm_NBK539147_toc_cl_app4"><a class="toc-item" href="/books/n/srcl0474/cl.app4/">APPENDIX 4. Detailed Outcome Data</a></li><li class="half_rhythm" id="toc_itm_NBK539147_toc_cl_app5"><a class="toc-item" href="/books/n/srcl0474/cl.app5/">APPENDIX 5. Validity of Outcome Measures</a></li><li class="half_rhythm" id="toc_itm_NBK539147_toc_rl_r1"><a class="toc-item" href="/books/n/srcl0474/rl.r1/">References</a></li></ul><div class="bktoc_all_cntnr align_right" style="display:none"><ul class="inline_list_right"><li><a class="bktoc_all_exp" href="#">Expand All</a></li><li style="margin-left:.8em"><a class="bktoc_all_clps" href="#">Collapse All</a></li></ul></div></div><div><b>Funding:</b> CADTH receives funding from Canada’s federal, provincial, and territorial governments, with the exception of Quebec.</div><div><p><b>Disclaimer:</b> The information in this document is intended to help Canadian health care decision-makers, health care professionals, health systems leaders, and policy-makers make well-informed decisions and thereby improve the quality of health care services. While patients and others may access this document, the document is made available for informational purposes only and no representations or warranties are made with respect to its fitness for any particular purpose. The information in this document should not be used as a substitute for professional medical advice or as a substitute for the application of clinical judgment in respect of the care of a particular patient or other professional judgment in any decision-making process. The Canadian Agency for Drugs and Technologies in Health (CADTH) does not endorse any information, drugs, therapies, treatments, products, processes, or services.</p><p>While care has been taken to ensure that the information prepared by CADTH in this document is accurate, complete, and up-to-date as at the applicable date the material was first published by CADTH, CADTH does not make any guarantees to that effect. CADTH does not guarantee and is not responsible for the quality, currency, propriety, accuracy, or reasonableness of any statements, information, or conclusions contained in any third-party materials used in preparing this document. The views and opinions of third parties published in this document do not necessarily state or reflect those of CADTH.</p><p>CADTH is not responsible for any errors, omissions, injury, loss, or damage arising from or relating to the use (or misuse) of any information, statements, or conclusions contained in or implied by the contents of this document or any of the source materials.</p><p>This document may contain links to third-party websites. CADTH does not have control over the content of such sites. Use of third-party sites is governed by the third-party website owners’ own terms and conditions set out for such sites. CADTH does not make any guarantee with respect to any information contained on such third-party sites and CADTH is not responsible for any injury, loss, or damage suffered as a result of using such third-party sites. CADTH has no responsibility for the collection, use, and disclosure of personal information by third-party sites.</p><p>Subject to the aforementioned limitations, the views expressed herein are those of CADTH and do not necessarily represent the views of Canada’s federal, provincial, or territorial governments or any third party supplier of information.</p><p>This document is prepared and intended for use in the context of the Canadian health care system. The use of this document outside of Canada is done so at the user’s own risk.</p><p>This disclaimer and any questions or matters of any nature arising from or relating to the content or use (or misuse) of this document will be governed by and interpreted in accordance with the laws of the Province of Ontario and the laws of Canada applicable therein, and all proceedings shall be subject to the exclusive jurisdiction of the courts of the Province of Ontario, Canada.</p><p><b>Redactions:</b> Confidential information in this document has been redacted at the request of the manufacturer in accordance with the <i>CADTH Common Drug Review Confidentiality Guidelines</i>.</p></div></div></div>
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<div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Views</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PDF_download" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/NBK539147/?report=reader">PubReader</a></li><li><a href="/books/NBK539147/?report=printable">Print View</a></li><li><a data-jig="ncbidialog" href="#_ncbi_dlg_citbx_NBK539147" data-jigconfig="width:400,modal:true">Cite this Page</a><div id="_ncbi_dlg_citbx_NBK539147" style="display:none" title="Cite this Page"><div class="bk_tt">Clinical Review Report: Ticagrelor (Brilinta) [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2016 Aug. <span class="bk_cite_avail"></span></div></div></li><li><a href="/books/n/srcl0474/pdf/">PDF version of this title</a> (746K)</li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Other titles in this collection</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="source-links" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/n/cadthcdrcollect/">CADTH Common Drug Reviews</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Related publications</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="document-links" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/NBK538942/">CADTH Canadian Drug Expert Committee Final Recommendation: Ticagrelor</a></li><li><a href="/books/NBK538959/">Pharmacoeconomic Review Report: Ticagrelor (Brilinta)</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Related information</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="Shutter"></a></div><div class="portlet_content"><ul><li class="brieflinkpopper"><a class="brieflinkpopperctrl" href="/books/?Db=nlmcatalog&DbFrom=books&Cmd=Link&LinkName=books_nlmcatalog&IdsFromResult=4745058" ref="log$=recordlinks">NLM Catalog</a><div class="brieflinkpop offscreen_noflow">Related NLM Catalog Entries</div></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Similar articles in PubMed</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PBooksDiscovery_RA" id="Shutter"></a></div><div class="portlet_content"><ul><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/30896904" ref="ordinalpos=1&linkpos=1&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Pharmacoeconomic Review Report: Ticagrelor (Brilinta)</a><span class="source">[ 2016]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Pharmacoeconomic Review Report: Ticagrelor (Brilinta)<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">2016 Aug</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/29150806" ref="ordinalpos=1&linkpos=2&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Ticagrelor: A Review in Long Term Secondary Prevention of Cardiovascular Events.</a><span class="source">[Drugs. 2017]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Ticagrelor: A Review in Long Term Secondary Prevention of Cardiovascular Events.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Al-Salama ZT, Keating GM, Keam SJ. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Drugs. 2017 Dec; 77(18):2025-2036. </em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/27046160" ref="ordinalpos=1&linkpos=3&log$=relatedarticles&logdbfrom=pubmed">Reduction in Ischemic Events With Ticagrelor in Diabetic Patients With Prior Myocardial Infarction in PEGASUS-TIMI 54.</a><span class="source">[J Am Coll Cardiol. 2016]</span><div class="brieflinkpop offscreen_noflow">Reduction in Ischemic Events With Ticagrelor in Diabetic Patients With Prior Myocardial Infarction in PEGASUS-TIMI 54.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Bhatt DL, Bonaca MP, Bansilal S, Angiolillo DJ, Cohen M, Storey RF, Im K, Murphy SA, Held P, Braunwald E, et al. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">J Am Coll Cardiol. 2016 Jun 14; 67(23):2732-2740. Epub 2016 Apr 1.</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/27576775" ref="ordinalpos=1&linkpos=4&log$=relatedarticles&logdbfrom=pubmed">Prevention of Stroke with Ticagrelor in Patients with Prior Myocardial Infarction: Insights from PEGASUS-TIMI 54 (Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction 54).</a><span class="source">[Circulation. 2016]</span><div class="brieflinkpop offscreen_noflow">Prevention of Stroke with Ticagrelor in Patients with Prior Myocardial Infarction: Insights from PEGASUS-TIMI 54 (Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction 54).<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Bonaca MP, Goto S, Bhatt DL, Steg PG, Storey RF, Cohen M, Goodrich E, Mauri L, Ophuis TO, Ruda M, et al. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Circulation. 2016 Sep 20; 134(12):861-71. Epub 2016 Aug 30.</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/24952855" ref="ordinalpos=1&linkpos=5&log$=relatedarticles&logdbfrom=pubmed">CYP2C19 genotype-guided antiplatelet therapy in ST-segment elevation myocardial infarction patients-Rationale and design of the Patient Outcome after primary PCI (POPular) Genetics study.</a><span class="source">[Am Heart J. 2014]</span><div class="brieflinkpop offscreen_noflow">CYP2C19 genotype-guided antiplatelet therapy in ST-segment elevation myocardial infarction patients-Rationale and design of the Patient Outcome after primary PCI (POPular) Genetics study.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Bergmeijer TO, Janssen PW, Schipper JC, Qaderdan K, Ishak M, Ruitenbeek RS, Asselbergs FW, van 't Hof AW, Dewilde WJ, Spanó F, et al. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Am Heart J. 2014 Jul; 168(1):16-22.e1. 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