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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK531245_"><span class="title" itemprop="name">Epoetin Beta</span></h1><p class="small">Last Revision: <span itemprop="dateModified">September 15, 2023</span>.</p><p><em>Estimated reading time: 1 minute</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 677324-53-7</p><div id="LM1416.Drug_Levels_and_Effects"><h2 id="_LM1416_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM1416.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Methoxy polyethylene glycol-epoetin beta is a synthetic form of erythropoietin that slowly releases the active drug, epoetin beta (recombinant human erythropoietin). Erythropoietin is a normal component of human milk. The excretion of exogenous methoxy polyethylene glycol-epoetin beta in breastmilk has not been studied; although the similar drug epoetin alfa has been studied and is considered to be acceptable during breastfeeding. Since no information is available on its use during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.</p></div><div id="LM1416.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Relevant published information on exogenous administration of epoetin beta was not found as of the revision date. However, breastmilk normally contains erythropoietin. Erythropoietin concentrations in human milk are in the range of approximately 4 to 5 units/L in the first 1 to 2 months postpartum and increase to 20 to 40 units/L by the third month and to 100 to 150 units/L by 12 months.[<a class="bk_pop" href="#LM1416.REF.1">1</a>]</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM1416.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Enhancement of gastrointestinal tract maturation has been proposed as a function of erythropoietin in breastmilk.[<a class="bk_pop" href="#LM1416.REF.1">1</a>,<a class="bk_pop" href="#LM1416.REF.2">2</a>]</p></div><div id="LM1416.Effects_on_Lactation_and_Breastmi"><h3>Effects on Lactation and Breastmilk</h3><p>In small studies, epoetin alfa administration decreased serum prolactin in patients with amyotrophic lateral sclerosis,[<a class="bk_pop" href="#LM1416.REF.3">3</a>] but had no effect in normal subjects or in patients with renal failure undergoing chronic ambulatory peritoneal dialysis.[<a class="bk_pop" href="#LM1416.REF.4">4</a>,<a class="bk_pop" href="#LM1416.REF.5">5</a>] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.</p></div><div id="LM1416.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p>
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<a href="/books/n/lactmed/LM496/">Epoetin Alfa</a>
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</p></div><div id="LM1416.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="LM1416.REF.1">Miller
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M, Iliff
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P, Stoltzfus
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RJ, Humphrey
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J. Breastmilk erythropoietin and mother-to-child HIV transmission through breastmilk.
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Lancet
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2002;360:1246-8.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/12401271" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12401271</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="LM1416.REF.2">Semba
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RD, Juul
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SE. Erythropoietin in human milk: Physiology and role in infant health.
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J Hum Lact
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2002;18:252-61.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/12192960" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12192960</span></a>]</div></dd><dt>3.</dt><dd><div class="bk_ref" id="LM1416.REF.3">Tokgöz
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B, Utas
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C, Dogukan
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A, et al.
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Influence of long term erythropoietin therapy on the hypothalamic-pituitary-thyroid axis in patients undergoing CAPD.
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Ren Fail
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2002;24:315-23.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/12166698" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12166698</span></a>]</div></dd><dt>4.</dt><dd><div class="bk_ref" id="LM1416.REF.4">Bernini
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GP, Mariotti
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F, Brogi
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G, et al.
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Effects of erythropoietin administration on prolactin secretion in normal subjects.
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Nephron
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1993;65:522-6.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/8302403" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 8302403</span></a>]</div></dd><dt>5.</dt><dd><div class="bk_ref" id="LM1416.REF.5">Markianos
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M, Kosmidis
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ML, Sfagos
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C. Reductions in plasma prolactin during acute erythropoietin administration.
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Neuro Endocrinol Lett
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2006;27:355-8.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/16816832" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16816832</span></a>]</div></dd></dl></div></div><div id="LM1416.Substance_Identification"><h2 id="_LM1416_Substance_Identification_">Substance Identification</h2><div id="LM1416.Substance_Name"><h3>Substance Name</h3><p>Epoetin Beta</p></div><div id="LM1416.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>677324-53-7</p></div><div id="LM1416.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Colony-Stimulating Factors</p><p>Hematinics</p><p>Hematopoietic Cell Growth Factors</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div><div class="small"><span class="label">Bookshelf ID: NBK531245</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/30277694" title="PubMed record of this page" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">30277694</a></span></div><div style="margin-top:2em" class="bk_noprnt"><a class="bk_cntns" href="/books/n/lactmed/">Contents</a><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/lactmed/LM496/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/lactmed/epoprostenol/" title="Next page in this title">Next ></a></div></div></div></div>
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