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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]" /><meta name="citation_title" content="Indacaterol" /><meta name="citation_publisher" content="National Institute of Child Health and Human Development" /><meta name="citation_date" content="2024/09/15" /><meta name="citation_pmid" content="30000976" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK501916/" /><meta name="citation_keywords" content="Indacaterol" /><meta name="citation_keywords" content="Arcapta Neohaler" /><meta name="citation_keywords" content="Arcapta" /><meta name="citation_keywords" content="QAB149" /><meta name="citation_keywords" content="QAB-149" /><meta name="citation_keywords" content="QAB 149" /><meta name="citation_keywords" content="UNII-8OR09251MQ" /><meta name="citation_keywords" content="8OR09251MQ" /><meta name="citation_keywords" content="5-{(1R)-2-((5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)amino)-1-hydroxyethyl}-8-hydroxyquinolin-2(1H)-one" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Indacaterol" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Child Health and Human Development" /><meta name="DC.Date" content="2024/09/15" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK501916/" /><meta name="description" content="Indacaterol is no longer marketed in the US. Although no published data exist on the use of indacaterol by mouth or inhaler during lactation, data from the related drug, terbutaline, indicate that very little is expected to be excreted into breastmilk.[1] The authors of several reviews and expert guidelines agree that use of inhaled bronchodilators is acceptable during breastfeeding because of the low bioavailability and maternal serum levels after use.[2-5]" /><meta name="og:title" content="Indacaterol" /><meta name="og:type" content="book" /><meta name="og:description" content="Indacaterol is no longer marketed in the US. Although no published data exist on the use of indacaterol by mouth or inhaler during lactation, data from the related drug, terbutaline, indicate that very little is expected to be excreted into breastmilk.[1] The authors of several reviews and expert guidelines agree that use of inhaled bronchodilators is acceptable during breastfeeding because of the low bioavailability and maternal serum levels after use.[2-5]" /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK501916/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-lactmed-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/lactmed/LM994/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK501916/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK501916_"><span class="title" itemprop="name">Indacaterol</span></h1><p class="small">Last Revision: <span itemprop="dateModified">September 15, 2024</span>.</p><p><em>Estimated reading time: 1 minute</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 312753-06-3</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/135252041" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=135252041" alt="image 135252041 in the ncbi pubchem database" /></a><div id="LM994.Drug_Levels_and_Effects"><h2 id="_LM994_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM994.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Indacaterol is no longer marketed in the US. Although no published data exist on the use of indacaterol by mouth or inhaler during lactation, data from the related drug, terbutaline, indicate that very little is expected to be excreted into breastmilk.[<a class="bk_pop" href="#LM994.REF.1">1</a>] The authors of several reviews and expert guidelines agree that use of inhaled bronchodilators is acceptable during breastfeeding because of the low bioavailability and maternal serum levels after use.[<a class="bk_pop" href="#LM994.REF.2">2</a>-<a class="bk_pop" href="#LM994.REF.5">5</a>]</p></div><div id="LM994.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Relevant published information was not found as of the revision date.</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM994.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM994.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM994.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p><a href="/books/n/lactmed/LM121/">Formoterol</a>, <a href="/books/n/lactmed/LM243/">Salmeterol</a></p></div><div id="LM994.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="LM994.REF.1">Lindberg
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C, Boréus
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LO, de Château
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P, et al.
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Transfer of terbutaline into breast milk.
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Eur J Respir Dis Suppl
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1984;134:87-91.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/6586490" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 6586490</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="LM994.REF.2">McDonald
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CF, Burdon
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JGW. Asthma in pregnancy and lactation. A position paper for the Thoracic Society of Australia and New Zealand.
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Med J Aust
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1996;165:485-8.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/8937369" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 8937369</span></a>]</div></dd><dt>3.</dt><dd><div class="bk_ref" id="LM994.REF.3">Nelson-Piercy
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C.
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Asthma in pregnancy.
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Thorax
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2001;56:325-8.
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[<a href="/pmc/articles/PMC1746013/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC1746013</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/11254828" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11254828</span></a>]</div></dd><dt>4.</dt><dd><div class="bk_ref" id="LM994.REF.4">Taddio A, Ito S. Drugs and breast-feeding. In, Koren G, ed. Maternal-fetal toxicology. A clinician's guide. 3rd ed. New York. Marcel Dekker. 2001:177-32.</div></dd><dt>5.</dt><dd><div class="bk_ref" id="LM994.REF.5">Bendien
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SA, de Kruif
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MD, Feitsma
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H, et al.
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Summary of the Dutch Multidisciplinary Practice Guideline on Asthma and Pregnancy.
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J Allergy Clin Immunol Pract
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2024;12:1751-62.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/38513758" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 38513758</span></a>]</div></dd></dl></div></div><div id="LM994.Substance_Identification"><h2 id="_LM994_Substance_Identification_">Substance Identification</h2><div id="LM994.Substance_Name"><h3>Substance Name</h3><p>Indacaterol</p></div><div id="LM994.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>312753-06-3</p></div><div id="LM994.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Anti-Asthmatic Agents</p><p>Beta Adrenergic Agonists</p><p>Bronchodilator Agents</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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