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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Sodium Phosphate - Drugs and Lactation Database (LactMed®) - NCBI Bookshelf</title>
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<meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]">
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<meta name="citation_title" content="Sodium Phosphate">
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<meta name="citation_date" content="2020/05/11">
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<meta name="citation_keywords" content="DISODIUM PHOSPHATE">
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<meta name="citation_keywords" content="Disodium hydrogen phosphate">
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<meta name="citation_keywords" content="Sodium phosphate">
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<meta name="citation_keywords" content="Acetest">
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<meta name="citation_keywords" content="Soda phosphate">
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<meta name="citation_keywords" content="Disodium hydrogenorthophosphate">
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<meta name="citation_keywords" content="Natriumphosphat">
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<meta name="citation_keywords" content="Fleet enema">
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<meta name="citation_keywords" content="Phosphate of soda">
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<meta name="citation_keywords" content="Dibasic sodium phosphate">
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<meta name="citation_keywords" content="Disodium orthophosphate">
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<meta name="citation_keywords" content="Sodium hydrogen phosphate">
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<meta name="citation_keywords" content="Disodium acid phosphate">
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<meta name="citation_keywords" content="Sodium phosphate, dibasic">
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<meta name="citation_keywords" content="Caswell No. 778">
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<meta name="citation_keywords" content="Disodium hydrophosphate">
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<meta name="citation_keywords" content="7558-79-4">
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<meta name="citation_keywords" content="Disodium phosphoric acid">
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<meta name="citation_keywords" content="Phosphoric acid, disodium salt">
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<meta name="citation_keywords" content="FEMA Number 2398">
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<meta name="citation_keywords" content="Natriumphosphat [German]">
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<meta name="citation_keywords" content="Disodium acid orthophosphate">
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<meta name="citation_keywords" content="secondary Sodium phosphate">
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<meta name="citation_keywords" content="Sodium monohydrogen phosphate">
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<meta name="citation_keywords" content="Exsiccated sodium phosphate">
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<meta name="citation_keywords" content="Disodium monohydrogen phosphate">
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<meta name="citation_keywords" content="Sodium phosphate (NaHPO4)">
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<meta name="citation_keywords" content="Sodium phosphate, exsiccated">
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<meta name="citation_keywords" content="UNII-22ADO53M6F">
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<meta name="citation_keywords" content="Disodium phosphate, anhydrous">
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<meta name="citation_keywords" content="FEMA No. 2398">
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<meta name="citation_keywords" content="CCRIS 5931">
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<meta name="citation_keywords" content="HSDB 376">
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<meta name="citation_keywords" content="Sodium orthophosphate, secondary">
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<meta name="citation_keywords" content="Sodium acid phosphate, anhydrous">
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<meta name="citation_keywords" content="22ADO53M6F">
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<meta name="citation_keywords" content="EINECS 231-448-7">
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<meta name="citation_keywords" content="Disodium hydrogen phosphate, anhydrous">
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<meta name="citation_keywords" content="Sodium phosphate, dibasic (anhydrous)">
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<meta name="citation_keywords" content="EPA Pesticide Chemical Code 076403">
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<meta name="citation_keywords" content="Sodium monohydrogen phosphate (2:1:1)">
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<meta name="citation_keywords" content="Phosphoric acid, sodium salt (1:2)">
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<meta name="citation_keywords" content="EC 231-448-7">
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<meta name="citation_keywords" content="DSP">
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<meta name="citation_keywords" content="Monosodium phosphate">
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<meta name="citation_keywords" content="Sodium dihydrogenorthophosphate">
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<meta name="citation_keywords" content="Sodium phosphate">
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<meta name="citation_keywords" content="SODIUM DIHYDROGEN PHOSPHATE">
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<meta name="citation_keywords" content="Sodium phosphate monobasic">
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<meta name="citation_keywords" content="Sodium acid phosphate">
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<meta name="citation_keywords" content="Uro-phosphate">
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<meta name="citation_keywords" content="Monosorb XP-4">
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<meta name="citation_keywords" content="Acid sodium phosphate">
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<meta name="citation_keywords" content="Monosodium orthophosphate">
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<meta name="citation_keywords" content="Sodium phosphate, monobasic">
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<meta name="citation_keywords" content="Monosodium monophosphate">
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<meta name="citation_keywords" content="Monobasic sodium phosphate">
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<meta name="citation_keywords" content="Primary sodium phosphate">
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<meta name="citation_keywords" content="Sodium primary phosphate">
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<meta name="citation_keywords" content="7558-80-7">
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<meta name="citation_keywords" content="UNII-KH7I04HPUU">
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<meta name="citation_keywords" content="Sodium biphosphate anhydrous">
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<meta name="citation_keywords" content="Monosodium dihydrogen phosphate">
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<meta name="citation_keywords" content="Monosodium dihydrogen orthophosphate">
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<meta name="citation_keywords" content="Monosodium hydrogen phosphate">
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<meta name="citation_keywords" content="KH7I04HPUU">
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<meta name="citation_keywords" content="Sodium dihydrogen orthophosphate">
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<meta name="citation_keywords" content="Sodium phosphate monobasic anhydrous">
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<meta name="citation_keywords" content="Sodium phosphate (NaH2PO4)">
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<meta name="citation_keywords" content="Phosphoric acid, monosodium salt">
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<meta name="citation_keywords" content="Sodium orthophosphate, primary">
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<meta name="citation_keywords" content="Sodium dihydrogen monophosphate">
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<meta name="citation_keywords" content="Monosodium phosphate, anhydrous">
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<meta name="citation_keywords" content="HSDB 738">
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<meta name="citation_keywords" content="Sodium phosphate (Na(H2PO4))">
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<meta name="citation_keywords" content="EINECS 231-449-2">
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<meta name="citation_keywords" content="Sodium dihydrogen phosphate (1:2:1)">
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<meta name="citation_keywords" content="Sodium dihydrogen phosphate, anhydrous">
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<meta name="citation_keywords" content="Sodium monobasic phosphate (NaH2PO4)">
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<meta name="citation_keywords" content="Sodium dihydrogen phosphate (NaH2PO4)">
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<meta name="citation_keywords" content="Phosphoric acid, sodium salt (1:1)">
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<meta name="citation_keywords" content="EC 231-449-2">
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<meta name="citation_keywords" content="MSP">
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<meta name="DC.Title" content="Sodium Phosphate">
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<meta name="DC.Type" content="Text">
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<meta name="DC.Publisher" content="National Institute of Child Health and Human Development">
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<meta name="DC.Date" content="2020/05/11">
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<meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK501909/">
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<meta name="description" content="Phosphate is a normal constituent of breastmilk. Phosphate concentrations have not been measured in breastmilk after large maternal doses of sodium phosphate, such a 30 gram oral dose for pre-procedural bowel evacuation. However, the added phosphate in breastmilk is likely to be only about 130 mg over 24 hours in this situation. The increase from a typical dose of a rectal enema would be considerably less than this amount. Breastmilk sodium concentration is tightly regulated, and will not be affected. It is probably not necessary to suspend breastfeeding after the use of oral sodium phosphate solutions given once or twice for bowel evacuation before a procedure. Use of a phosphate rectal enema by a nursing mother would require no special precautions.">
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<meta name="og:title" content="Sodium Phosphate">
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<meta name="og:description" content="Phosphate is a normal constituent of breastmilk. Phosphate concentrations have not been measured in breastmilk after large maternal doses of sodium phosphate, such a 30 gram oral dose for pre-procedural bowel evacuation. However, the added phosphate in breastmilk is likely to be only about 130 mg over 24 hours in this situation. The increase from a typical dose of a rectal enema would be considerably less than this amount. Breastmilk sodium concentration is tightly regulated, and will not be affected. It is probably not necessary to suspend breastfeeding after the use of oral sodium phosphate solutions given once or twice for bowel evacuation before a procedure. Use of a phosphate rectal enema by a nursing mother would require no special precautions.">
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class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK501909_"><span class="title" itemprop="name">Sodium Phosphate</span></h1><p class="fm-aai"><a href="#_NBK501909_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 2 minutes</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><p>CASRN: 7558-79-4; 7558-80-7</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134986680" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134986680" alt="image 134986680 in the ncbi pubchem database" /></a><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134986681" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134986681" alt="image 134986681 in the ncbi pubchem database" /></a><div id="LM988.Drug_Levels_and_Effects"><h2 id="_LM988_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM988.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Phosphate is a normal constituent of breastmilk. Phosphate concentrations have not been measured in breastmilk after large maternal doses of sodium phosphate, such a 30 gram oral dose for pre-procedural bowel evacuation. However, the added phosphate in breastmilk is likely to be only about 130 mg over 24 hours in this situation. The increase from a typical dose of a rectal enema would be considerably less than this amount. Breastmilk sodium concentration is tightly regulated, and will not be affected. It is probably not necessary to suspend breastfeeding after the use of oral sodium phosphate solutions given once or twice for bowel evacuation before a procedure. Use of a phosphate rectal enema by a nursing mother would require no special precautions.</p></div><div id="LM988.Drug_Levels"><h3>Drug Levels</h3><p>Phosphate is a normal constituent of breastmilk.[<a class="bibr" href="#LM988.REF.1" rid="LM988.REF.1">1</a>,<a class="bibr" href="#LM988.REF.2" rid="LM988.REF.2">2</a>] Infants normally receive about 130 mg of inorganic phosphate daily from breastmilk.[<a class="bibr" href="#LM988.REF.2" rid="LM988.REF.2">2</a>]</p><p><i>Maternal Levels.</i> Administration of a 30 gram dose of oral sodium phosphate solution (e.g., Visicol) approximately doubles the maternal serum phosphate concentration, with serum concentrations returning to baseline about 24 hours after the dose.[<a class="bibr" href="#LM988.REF.3" rid="LM988.REF.3">3</a>,<a class="bibr" href="#LM988.REF.4" rid="LM988.REF.4">4</a>] Assuming breastmilk phosphate concentration also doubles, the increased phosphate dose to the infant would be only 130 mg for one day.</p><p>Administration of a phosphate enema (2 Fleet Enemas, containing a total of 14 grams of sodium phosphate dibasic and 38 grams of sodium phosphate monobasic) to 33 subjects increased serum phosphate by an average of about 25% (range 0.1 to 2.5 mg/dL).[<a class="bibr" href="#LM988.REF.5" rid="LM988.REF.5">5</a>] In one other patient, a phosphate enema (Practo Clyss 120, containing a total of 7.2 grams of sodium phosphate dibasic and 19.2 grams of sodium phosphate monobasic) increased serum phosphate by 35% (by 0.8 mmol/L) after a single dose.[<a class="bibr" href="#LM988.REF.6" rid="LM988.REF.6">6</a>]</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM988.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM988.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM988.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="LM988.REF.1">Kent JC, Arthur PG, Retallack RW, et al. Calcium, phosphate and citrate in human milk at initiation of lactation. <span><span class="ref-journal">J Dairy Res. </span>1992;<span class="ref-vol">59</span>:161–7.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/1613174" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 1613174</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="LM988.REF.2">Allen JC, Keller RP, Archer P, et al. Studies in human lactation: Milk composition and daily secretion rates of macronutrients in the first year of lactation. <span><span class="ref-journal">Am J Clin Nutr. </span>1991;<span class="ref-vol">54</span>:69–80.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/2058590" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 2058590</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="LM988.REF.3">Visicol package insert. Salix Pharmaceuticals, Inc; December 2010.</div></dd></dl><dl class="bkr_refwrap"><dt>4.</dt><dd><div class="bk_ref" id="LM988.REF.4">Ehrenpreis ED. Increased serum phosphate levels and calcium fluxes are seen in smaller individuals after a single dose of sodium phosphate colon cleansing solution: a pharmacokinetic analysis. <span><span class="ref-journal">Aliment Pharmacol Ther. </span>2009;<span class="ref-vol">29</span>:1202–11.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/19298584" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19298584</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>5.</dt><dd><div class="bk_ref" id="LM988.REF.5">Schuchmann GD, Barcia PJ. Phosphate absorption from fleet enemas in adults. <span><span class="ref-journal">Curr Surg. </span>1989;<span class="ref-vol">46</span>:120–2.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/2736963" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 2736963</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>6.</dt><dd><div class="bk_ref" id="LM988.REF.6">Rimensberger P, Schubiger G, Willi U. Connatal rickets following repeated administration of phosphate enemas in pregnancy: a case report. <span><span class="ref-journal">Eur J Pediatr. </span>1992;<span class="ref-vol">151</span>:54–6.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/1728548" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 1728548</span></a>]</div></dd></dl></dl></div></div><div id="LM988.Substance_Identification"><h2 id="_LM988_Substance_Identification_">Substance Identification</h2><div id="LM988.Substance_Name"><h3>Substance Name</h3><p>Sodium Phosphate</p></div><div id="LM988.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>7558-79-4; 7558-80-7</p></div><div id="LM988.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Cathartics</p><p>Electrolyte</p><p>Gastrointestinal Agents</p><p>Minerals</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK501909_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">May 11, 2020</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. 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