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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Coleus - Drugs and Lactation Database (LactMed®) - NCBI Bookshelf</title>
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<meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]">
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<meta name="citation_title" content="Coleus">
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<meta name="citation_publisher" content="National Institute of Child Health and Human Development">
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<meta name="citation_date" content="2025/01/15">
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<meta name="citation_keywords" content="Coleus amboinicus lour">
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<meta name="citation_keywords" content="Plectranthus amboinicus">
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<meta name="citation_keywords" content="Torbangun">
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<meta name="citation_keywords" content="bangun-bangun">
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<meta name="DC.Title" content="Coleus">
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<meta name="description" content="Coleus amboinicus (Plectranthus amboinicus) leaves are a traditional galactogogue used in Indonesia called torbangun or bangun-bangun in the local languages.[1] Human studies of poor quality and some rodent studies indicate that it might have some efficacy as a galactogogue, but the studies are inadequate to establish activity.[2-4] Galactogogues should never replace evaluation and counseling on modifiable factors that affect milk production.[5,6] No data exist on the excretion of any components of Coleus amboinicus into breastmilk or on the safety and efficacy of Coleus amboinicus in nursing mothers or infants, although it has been used for hundreds of years in Indonesia with apparent safety. A related plant, Coleus forskohlii, is well tolerated as a supplement.">
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<meta name="og:description" content="Coleus amboinicus (Plectranthus amboinicus) leaves are a traditional galactogogue used in Indonesia called torbangun or bangun-bangun in the local languages.[1] Human studies of poor quality and some rodent studies indicate that it might have some efficacy as a galactogogue, but the studies are inadequate to establish activity.[2-4] Galactogogues should never replace evaluation and counseling on modifiable factors that affect milk production.[5,6] No data exist on the excretion of any components of Coleus amboinicus into breastmilk or on the safety and efficacy of Coleus amboinicus in nursing mothers or infants, although it has been used for hundreds of years in Indonesia with apparent safety. A related plant, Coleus forskohlii, is well tolerated as a supplement.">
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class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK501874_"><span class="title" itemprop="name">Coleus</span></h1><p class="fm-aai"><a href="#_NBK501874_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 3 minutes</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><div id="LM956.Drug_Levels_and_Effects"><h2 id="_LM956_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM956.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p><i>Coleus amboinicus</i> (<i>Plectranthus amboinicus</i>) leaves are a traditional galactogogue used in Indonesia called torbangun or bangun-bangun in the local languages.[<a class="bibr" href="#LM956.REF.1" rid="LM956.REF.1">1</a>] Human studies of poor quality and some rodent studies indicate that it might have some efficacy as a galactogogue, but the studies are inadequate to establish activity.[<a class="bibr" href="#LM956.REF.2" rid="LM956.REF.2">2</a>-<a class="bibr" href="#LM956.REF.4" rid="LM956.REF.4">4</a>] Galactogogues should never replace evaluation and counseling on modifiable factors that affect milk production.[<a class="bibr" href="#LM956.REF.5" rid="LM956.REF.5">5</a>,<a class="bibr" href="#LM956.REF.6" rid="LM956.REF.6">6</a>] No data exist on the excretion of any components of <i>Coleus amboinicus</i> into breastmilk or on the safety and efficacy of <i>Coleus amboinicus</i> in nursing mothers or infants, although it has been used for hundreds of years in Indonesia with apparent safety. A related plant, <i>Coleus forskohlii</i>, is well tolerated as a supplement.</p><p>Dietary supplements do not require extensive pre-marketing approval from the U.S. Food and Drug Administration. Manufacturers are responsible to ensure the safety, but do not need to <i>prove</i> the safety and effectiveness of dietary supplements before they are marketed. Dietary supplements may contain multiple ingredients, and differences are often found between labeled and actual ingredients or their amounts. A manufacturer may contract with an independent organization to verify the quality of a product or its ingredients, but that does <i>not</i> certify the safety or effectiveness of a product. Because of the above issues, clinical testing results on one product may not be applicable to other products. More detailed information <a href="/books/n/lactmed/LactMedDietarySupps/?report=reader">about dietary supplements</a> is available elsewhere on the LactMed Web site.</p></div><div id="LM956.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Relevant published information was not found as of the revision date.</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM956.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM956.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>A study of 67 healthy women who delivered a fullterm infant and desired to breastfeed for at least 4 months compared torbangun (<i>Coleus amboinicus</i>), fenugreek, and a control product containing placental extract and vitamin B12 (Molocco+B12) for their effects on breastmilk volume. No mention was made of any breastfeeding support provided to the women. Participants were randomly assigned to receive one of the products for 30 days and followed for another 30 days. A soup was made from 150 grams of <i>Coleus amboinicus</i> leaves 6 days per week for 30 days, beginning on the second postpartum day, and it was consumed during the day. Infants were weighed before and after each nursing at 2-week intervals during the study to measure 24-hour milk volume. In the torbangun group, the milk volume on day 28 was statistically greater than on day 14. The increase in milk volume on day 28 was 33% in the torbangun group, compared to a decrease of 15% in the control group and a decrease of 14% in the fenugreek group. However, the baseline production in the torbangun group was 20 to 23% lower than in the other groups and there was no statistical difference in milk volume at any time compared to the initial volume of milk in the control group. Analysis of breastmilk found no decrease in nutritional quality of milk in the torbangun group.[<a class="bibr" href="#LM956.REF.7" rid="LM956.REF.7">7</a>]</p><p>A nonrandomized, unblinded study in Indonesia gave some mothers <i>Coleus</i>
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<i>amboinicus</i> leaves as a soup and other mothers nothing for 7 days after delivery. Based on maternal surveys, those who ingested <i>Coleus</i> appeared to produce milk a few hours sooner than those who did not (average 2.37 vs 3 days) and supplement their infants less frequently.[<a class="bibr" href="#LM956.REF.4" rid="LM956.REF.4">4</a>]</p><p>A nonblinded study in Indonesia randomized postpartum women with perceived low milk supply to either an herbal decoction containing 25 grams <i>Sauropus androgynus</i> (katuk) leaves, 10 grams <i>Coleus amboinicus</i> (torbangun) leaves and 5 grams papaya leaves (n = 60) or to 500 mg <i>Sauropus androgynus</i> extract (CV Al-Ghuroba, Indonesia; n = 60). Patients were to take the product and weigh their infant twice daily for 28 days. Maternal serum prolactin was measured on day 14 and 28. Breast milk volume and infant’s weight increased on days 14 and 28, and serum prolactin levels in decreased in both groups; however, the changes were not statistically significant. Mean infant weights increased, with no difference between the two treatments. Two mothers in the combination group and 3 in the extract group had increases in aspartate aminotransferase and/or alanine aminotransferase.[<a class="bibr" href="#LM956.REF.8" rid="LM956.REF.8">8</a>]</p></div><div id="LM956.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="LM956.REF.1">Damanik
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R.
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Torbangun (<em>Coleus amboinicus</em> lour): A Bataknese traditional cuisine perceived as lactagogue by Bataknese lactating women in Simalungun, North Sumatera, Indonesia.
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J Hum Lact
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2009;25:64-72.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/18984829" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18984829</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="LM956.REF.2">Mortel
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M, Mehta
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SD. Systematic review of the efficacy of herbal galactogogues.
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J Hum Lact
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2013;29:154-62.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/23468043" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 23468043</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="LM956.REF.3">Zapantis
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A, Steinberg
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JG, Schilit
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L. Use of herbals as galactagogues.
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J Pharm Pract
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2012;25:222-31.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/22392841" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 22392841</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>4.</dt><dd><div class="bk_ref" id="LM956.REF.4">Nasution
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SS, Eliana
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R, Aizar
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E, et al.
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Effectiveness of <em>Coleus amboinicus</em> consumption interventions in increasing breast milk production and improving maternal health status during COVID 19 pandemic.
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Open Access Macedonian J Med Sci
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2022;10:202-8. doi:10.3889/oamjms.2022.7094 [<a href="http://dx.crossref.org/10.3889/oamjms.2022.7094" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">CrossRef</a>]</div></dd></dl><dl class="bkr_refwrap"><dt>5.</dt><dd><div class="bk_ref" id="LM956.REF.5">Brodribb W. ABM Clinical Protocol #9: Use of galactogogues in initiating or augmenting maternal milk production, second revision 2018.
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Breastfeed Med
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2018;13:307-14.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/29902083" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 29902083</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>6.</dt><dd><div class="bk_ref" id="LM956.REF.6">Breastfeeding challenges: ACOG Committee Opinion, Number 820.
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Obstet Gynecol
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2021;137:e42-e53.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/33481531" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 33481531</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>7.</dt><dd><div class="bk_ref" id="LM956.REF.7">Damanik
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R, Wahlqvist
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ML, Wattanapenpaiboon
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N. Lactagogue effects of Torbangun, a Bataknese traditional cuisine.
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Asia Pac J Clin Nutr
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2006;15:267-74.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/16672214" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16672214</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>8.</dt><dd><div class="bk_ref" id="LM956.REF.8">Zulkarnain
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Z, Fitriani
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U, Ardiyanto
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D, et al.
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Galactagogue activity of poly-herbal decoction from Indonesia: A randomized open label controlled trial.
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J Complement Integr Med
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2024;21:532-9.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/38644615" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 38644615</span></a>]</div></dd></dl></dl></div></div><div id="LM956.Substance_Identification"><h2 id="_LM956_Substance_Identification_">Substance Identification</h2><div id="LM956.Substance_Name"><h3>Substance Name</h3><p>Coleus</p></div><div id="LM956.Scientific_Name"><h3>Scientific Name</h3><p>Coleus amboinicus</p></div><div id="LM956.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Complementary Therapies</p><p>Phytotherapy</p><p>Plants, Medicinal</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK501874_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">January 15, 2025</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Coleus. [Updated 2025 Jan 15].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/lactmed/LM514/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/lactmed/LM453/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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