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Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug." /><meta name="og:title" content="Dimenhydrinate" /><meta name="og:type" content="book" /><meta name="og:description" content="Small, occasional doses of dimenhydrinate would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. 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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK501867_"><span class="title" itemprop="name">Dimenhydrinate</span></h1><p class="small">Last Revision: <span itemprop="dateModified">September 20, 2021</span>.</p><p><em>Estimated reading time: 2 minutes</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 523-87-5</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134977797" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134977797" alt="image 134977797 in the ncbi pubchem database" /></a><div id="LM95.Drug_Levels_and_Effects"><h2 id="_LM95_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM95.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Small, occasional doses of dimenhydrinate would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug.</p></div><div id="LM95.Drug_Levels"><h3>Drug Levels</h3><p>Dimenhydrinate is the 8-chlortheophyllinate salt of diphenhydramine.</p><p><i>Maternal Levels.</i> One old study that used a biologic assay system reported that after a 100 mg intramuscular dose of diphenhydramine in four women, drug levels in milk were undetectable in two and 42 and 100 mcg/L in two others at one hour after the dose. Five hours after the dose, milk levels were undetectable in two women and 20 and 100 mcg/L in two others.[<a class="bk_pop" href="#LM95.REF.1">1</a>] No studies using modern assay methods have been reported.</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM95.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information on dimenhydrinate was not found as of the revision date. In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, irritability was reported in one infant of seven exposed to dimenhydrinate in breastmilk.[<a class="bk_pop" href="#LM95.REF.2">2</a>]</p></div><div id="LM95.Effects_on_Lactation_and_Breastmilk"><h3>Effects on Lactation and Breastmilk</h3><p>Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[<a class="bk_pop" href="#LM95.REF.3">3</a>,<a class="bk_pop" href="#LM95.REF.4">4</a>] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[<a class="bk_pop" href="#LM95.REF.3">3</a>] Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.</p><p>One woman became dependent on dimenhydrinate during her first pregnancy and continued to take it in a dose of 150 mg daily while she breastfed her infant for 3 months. The infant did well except for a febrile seizure at 2 years of age, which was probably unrelated to dimenhydrinate. During her second pregnancy, she took dimenhydrinate 300 mg daily during the pregnancy and while breastfeeding her infant for 2 years.[<a class="bk_pop" href="#LM95.REF.5">5</a>]</p></div><div id="LM95.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p>
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<a href="/books/n/lactmed/LM553/">Meclizine</a>
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</p></div><div id="LM95.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="LM95.REF.1">Rindi V. La eliminazione degli antistaminici di sintesi con il latte e l'azione latto-goga de questi. <span><span class="ref-journal">Riv Ital Ginecol. </span>1951;<span class="ref-vol">34</span>:147–57.</span></div></dd><dt>2.</dt><dd><div class="bk_ref" id="LM95.REF.2">Ito S, Blajchman A, Stephenson M, et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. <span><span class="ref-journal">Am J Obstet Gynecol. </span>1993;<span class="ref-vol">168</span>:1393–9.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/8498418" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 8498418</span></a>]</div></dd><dt>3.</dt><dd><div class="bk_ref" id="LM95.REF.3">Messinis IE, Souvatzoglou A, Fais N, et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. <span><span class="ref-journal">J Endocrinol Invest. </span>1985;<span class="ref-vol">8</span>:143–6.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/3928731" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 3928731</span></a>]</div></dd><dt>4.</dt><dd><div class="bk_ref" id="LM95.REF.4">Pontiroli AE, De Castro e Silva E, Mazzoleni F, et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: Sex differences and the role of stress. <span><span class="ref-journal">J Clin Endocrinol Metab. </span>1981;<span class="ref-vol">52</span>:924–8.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/7228996" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 7228996</span></a>]</div></dd><dt>5.</dt><dd><div class="bk_ref" id="LM95.REF.5">Kaya FD. A patient with dimenhydrinate dependence: A case report. <span><span class="ref-journal">Klin Psikofarmakol Bull. </span>2014;<span class="ref-vol">24</span>:184–7.</span> [<a href="http://dx.crossref.org/10.5455/bcp.20140131023347" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">CrossRef</a>]</div></dd></dl></div></div><div id="LM95.Substance_Identification"><h2 id="_LM95_Substance_Identification_">Substance Identification</h2><div id="LM95.Substance_Name"><h3>Substance Name</h3><p>Dimenhydrinate</p></div><div id="LM95.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>523-87-5</p></div><div id="LM95.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Antihistamines</p><p>Antiemetics</p><p>Gastrointestinal Agents</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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