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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]" /><meta name="citation_title" content="Goldenseal" /><meta name="citation_publisher" content="National Institute of Child Health and Human Development" /><meta name="citation_date" content="2024/12/15" /><meta name="citation_pmid" content="30000926" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK501866/" /><meta name="citation_keywords" content="Goldenseal" /><meta name="citation_keywords" content="Hydrastis" /><meta name="citation_keywords" content="Opsonat" /><meta name="citation_keywords" content="Guna-lympho" /><meta name="citation_keywords" content="Goldenseal powder" /><meta name="citation_keywords" content="Extract of golden seal" /><meta name="citation_keywords" content="Hydrastis canadensis extract" /><meta name="citation_keywords" content="EINECS 283-261-5" /><meta name="citation_keywords" content="Golden seal, Hydrastis canadensis, ext" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Goldenseal" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Child Health and Human Development" /><meta name="DC.Date" content="2024/12/15" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK501866/" /><meta name="description" content="Goldenseal (Hydrastis canadensis) root contains berberine and other isoquinoline alkaloids. Goldenseal has traditionally been used as an anti-infective both systemically and topically, although high-quality studies of its efficacy and safety are lacking. It has also been used to mask illicit drugs in the urine, although it appears to be ineffective with modern laboratory methods. Goldenseal has been used topically by nursing mothers to treat sore nipples.[1] No data exist on the excretion of any components of goldenseal into breastmilk or on the safety and efficacy of goldenseal in nursing mothers. Berberine can displace bilirubin from serum albumin, causing concern about exposure of newborn infants, because bilirubin can build up in the infant's brain, causing brain damage. However, the extent of berberine's passage from the mother to the infant is unknown. Most sources recommend avoiding exposure of neonates to goldenseal via breastfeeding or otherwise.[2-4]" /><meta name="og:title" content="Goldenseal" /><meta name="og:type" content="book" /><meta name="og:description" content="Goldenseal (Hydrastis canadensis) root contains berberine and other isoquinoline alkaloids. Goldenseal has traditionally been used as an anti-infective both systemically and topically, although high-quality studies of its efficacy and safety are lacking. It has also been used to mask illicit drugs in the urine, although it appears to be ineffective with modern laboratory methods. Goldenseal has been used topically by nursing mothers to treat sore nipples.[1] No data exist on the excretion of any components of goldenseal into breastmilk or on the safety and efficacy of goldenseal in nursing mothers. Berberine can displace bilirubin from serum albumin, causing concern about exposure of newborn infants, because bilirubin can build up in the infant's brain, causing brain damage. However, the extent of berberine's passage from the mother to the infant is unknown. Most sources recommend avoiding exposure of neonates to goldenseal via breastfeeding or otherwise.[2-4]" /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK501866/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-lactmed-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/lactmed/LM949/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK501866/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK501866_"><span class="title" itemprop="name">Goldenseal</span></h1><p class="small">Last Revision: <span itemprop="dateModified">December 15, 2024</span>.</p><p><em>Estimated reading time: 1 minute</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 84603-60-1</p><div id="LM949.Drug_Levels_and_Effects"><h2 id="_LM949_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM949.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Goldenseal (<i>Hydrastis canadensis</i>) root contains berberine and other isoquinoline alkaloids. Goldenseal has traditionally been used as an anti-infective both systemically and topically, although high-quality studies of its efficacy and safety are lacking. It has also been used to mask illicit drugs in the urine, although it appears to be ineffective with modern laboratory methods. Goldenseal has been used topically by nursing mothers to treat sore nipples.[<a class="bk_pop" href="#LM949.REF.1">1</a>] No data exist on the excretion of any components of goldenseal into breastmilk or on the safety and efficacy of goldenseal in nursing mothers. Berberine can displace bilirubin from serum albumin, causing concern about exposure of newborn infants, because bilirubin can build up in the infant's brain, causing brain damage. However, the extent of berberine's passage from the mother to the infant is unknown. Most sources recommend avoiding exposure of neonates to goldenseal via breastfeeding or otherwise.[<a class="bk_pop" href="#LM949.REF.2">2</a>-<a class="bk_pop" href="#LM949.REF.4">4</a>]</p><p>Dietary supplements do not require extensive pre-marketing approval from the U.S. Food and Drug Administration. Manufacturers are responsible to ensure the safety, but do not need to <i>prove</i> the safety and effectiveness of dietary supplements before they are marketed. Dietary supplements may contain multiple ingredients, and differences are often found between labeled and actual ingredients or their amounts. A manufacturer may contract with an independent organization to verify the quality of a product or its ingredients, but that does <i>not</i> certify the safety or effectiveness of a product. Because of the above issues, clinical testing results on one product may not be applicable to other products. More detailed information <a href="https://toxnet.nlm.nih.gov/help/LactMedDietarySupps.htm" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">about dietary supplements</a> is available elsewhere on the LactMed Web site.</p></div><div id="LM949.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Relevant published information was not found as of the revision date.</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM949.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM949.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM949.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="LM949.REF.1">Fleiss
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P.
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Herbal remedies for the breastfeeding mother.
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Mothering
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1988;Summer:68-71.</div></dd><dt>2.</dt><dd><div class="bk_ref" id="LM949.REF.2">Amir
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L, Pirotta
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M, Raval
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M.
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Breastfeeding - Evidence based guidelines for the use of medicines.
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Aust Fam Physician
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2011;40:684-90.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/21894275" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21894275</span></a>]</div></dd><dt>3.</dt><dd><div class="bk_ref" id="LM949.REF.3">O'Hara
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M, Kiefer
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D, Farrell
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K, et al.
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A review of 12 commonly used medicinal herbs.
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Arch Fam Med
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1998;7:523-36.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/9821826" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9821826</span></a>]</div></dd><dt>4.</dt><dd><div class="bk_ref" id="LM949.REF.4">Yarnell
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E.
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Botanical medicine in pregnancy and lactation.
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Altern Complement Ther
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1997;3 (April):93-100. doi:10.1089/act.1997.3.93 [<a href="http://dx.crossref.org/10.1089/act.1997.3.93" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">CrossRef</a>]</div></dd></dl></div></div><div id="LM949.Substance_Identification"><h2 id="_LM949_Substance_Identification_">Substance Identification</h2><div id="LM949.Substance_Name"><h3>Substance Name</h3><p>Goldenseal</p></div><div id="LM949.Scientific_Name"><h3>Scientific Name</h3><p>Hydrastis canadensis</p></div><div id="LM949.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>84603-60-1</p></div><div id="LM949.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Complementary Therapies</p><p>Phytotherapy</p><p>Plants, Medicinal</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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