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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Levocarnitine - Drugs and Lactation Database (LactMed®) - NCBI Bookshelf</title>
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<meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]">
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<meta name="citation_title" content="Levocarnitine">
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<meta name="citation_publisher" content="National Institute of Child Health and Human Development">
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<meta name="citation_date" content="2024/10/15">
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<meta name="citation_pmid" content="30000924">
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<meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK501864/">
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<meta name="citation_keywords" content="L-carnitine">
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<meta name="citation_keywords" content="Levocarnitine">
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<meta name="citation_keywords" content="Carnitine">
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<meta name="citation_keywords" content="vitamin BT">
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<meta name="citation_keywords" content="Carnitor">
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<meta name="citation_keywords" content="(R)-Carnitine">
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<meta name="citation_keywords" content="Karnitin">
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<meta name="citation_keywords" content="(-)-Carnitine">
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<meta name="citation_keywords" content="Levocarnitina">
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<meta name="citation_keywords" content="levocarnitinum">
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<meta name="citation_keywords" content="Metina">
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<meta name="citation_keywords" content="Carnitolo">
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<meta name="citation_keywords" content="Carnovis">
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<meta name="citation_keywords" content="Carrier">
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<meta name="citation_keywords" content="Lefcar">
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<meta name="citation_keywords" content="UNII-0G389FZZ9M">
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<meta name="citation_keywords" content="ST 198">
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<meta name="citation_keywords" content="0G389FZZ9M">
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<meta name="citation_keywords" content="HSDB 7588">
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<meta name="citation_keywords" content="EINECS 208-768-0">
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<meta name="citation_keywords" content="acetylcarnitine">
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<meta name="citation_keywords" content="Acetyl-L-carnitine">
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<meta name="citation_keywords" content="Nicetile">
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<meta name="citation_keywords" content="ALCAR">
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<meta name="citation_keywords" content="UNII-6DH1W9VH8Q">
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<meta name="citation_keywords" content="Carnitine, acetyl-, L-">
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<meta name="citation_keywords" content="6DH1W9VH8Q">
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<meta name="citation_keywords" content="HSDB 7587">
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<meta name="citation_keywords" content="Propionylcarnitine">
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<meta name="citation_keywords" content="Propionyl carnitine">
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<meta name="citation_keywords" content="L-Propionylcarnitine">
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<meta name="citation_keywords" content="Propionyl-L-Carnitine">
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<meta name="citation_keywords" content="HSDB 7589">
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<meta name="citation_keywords" content="(3R)-3-hydroxy-4-(trimethylazaniumyl)butanoate">
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<meta name="citation_keywords" content="(3R)-3-acetyloxy-4-(trimethylazaniumyl)butanoate">
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<meta name="citation_keywords" content="3-propanoyloxy-4-(trimethylazaniumyl)butanoate">
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<link rel="schema.DC" href="http://purl.org/DC/elements/1.0/">
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<meta name="DC.Title" content="Levocarnitine">
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<meta name="DC.Type" content="Text">
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<meta name="DC.Publisher" content="National Institute of Child Health and Human Development">
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<meta name="DC.Date" content="2024/10/15">
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<meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK501864/">
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<meta name="description" content="Levocarnitine and acetyl-l-carnitine (acetlycarnitine) are normal components of human milk that are required for fat metabolism. The body can use only levocarnitine; dextrocarnitine can be an antagonist of levocarnitine. Acetyl-l-carnitine, and propionyl-l-carnitine can be converted to levocarnitine by the body. The bioavailability of levocarnitine is less than 20%, but acetlycarnitine and propionlycarnitine may be higher. These substances have no specific lactation-related uses. Within the normal range of dietary intake, excretion of levocarnitine into breastmilk is relatively constant. Women with carnitine deficiency appear to secrete insufficient amounts of carnitine into their breastmilk for their breastfed infants, who may require levocarnitine supplementation.[1] Preterm infants are often deficient in levocarnitine and require supplementation.[2] No data exist on the safety and efficacy levocarnitine supplementation in nursing mothers or infants without carnitine deficiency. Levocarnitine and its derivatives are generally well tolerated in adults with occasional gastrointestinal upset and restlessness. A fishy odor to the breath, sweat and urine has been reported. Although data are very limited, poor bioavailability might limit absorption by the breastfed infant. It appears unlikely that maternal levocarnitine supplements during nursing would be harmful to the infant, but until more data are available, it is probably best to avoid levocarnitine supplementation unless a healthcare professional prescribes it.">
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<meta name="og:title" content="Levocarnitine">
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<meta name="og:type" content="book">
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<meta name="og:description" content="Levocarnitine and acetyl-l-carnitine (acetlycarnitine) are normal components of human milk that are required for fat metabolism. The body can use only levocarnitine; dextrocarnitine can be an antagonist of levocarnitine. Acetyl-l-carnitine, and propionyl-l-carnitine can be converted to levocarnitine by the body. The bioavailability of levocarnitine is less than 20%, but acetlycarnitine and propionlycarnitine may be higher. These substances have no specific lactation-related uses. Within the normal range of dietary intake, excretion of levocarnitine into breastmilk is relatively constant. Women with carnitine deficiency appear to secrete insufficient amounts of carnitine into their breastmilk for their breastfed infants, who may require levocarnitine supplementation.[1] Preterm infants are often deficient in levocarnitine and require supplementation.[2] No data exist on the safety and efficacy levocarnitine supplementation in nursing mothers or infants without carnitine deficiency. Levocarnitine and its derivatives are generally well tolerated in adults with occasional gastrointestinal upset and restlessness. A fishy odor to the breath, sweat and urine has been reported. Although data are very limited, poor bioavailability might limit absorption by the breastfed infant. It appears unlikely that maternal levocarnitine supplements during nursing would be harmful to the infant, but until more data are available, it is probably best to avoid levocarnitine supplementation unless a healthcare professional prescribes it.">
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class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK501864_"><span class="title" itemprop="name">Levocarnitine</span></h1><p class="fm-aai"><a href="#_NBK501864_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 4 minutes</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><p>CASRN: 541-15-1; 3040-38-8; 17298-37-2</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134975930" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134975930" alt="image 134975930 in the ncbi pubchem database" /></a><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134982290" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134982290" alt="image 134982290 in the ncbi pubchem database" /></a><a href="https://pubchem.ncbi.nlm.nih.gov/substance/135066021" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=135066021" alt="image 135066021 in the ncbi pubchem database" /></a><div id="LM947.Drug_Levels_and_Effects"><h2 id="_LM947_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM947.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Levocarnitine and acetyl-l-carnitine (acetlycarnitine) are normal components of human milk that are required for fat metabolism. The body can use only levocarnitine; dextrocarnitine can be an antagonist of levocarnitine. Acetyl-l-carnitine, and propionyl-l-carnitine can be converted to levocarnitine by the body. The bioavailability of levocarnitine is less than 20%, but acetlycarnitine and propionlycarnitine may be higher. These substances have no specific lactation-related uses. Within the normal range of dietary intake, excretion of levocarnitine into breastmilk is relatively constant. Women with carnitine deficiency appear to secrete insufficient amounts of carnitine into their breastmilk for their breastfed infants, who may require levocarnitine supplementation.[<a class="bibr" href="#LM947.REF.1" rid="LM947.REF.1">1</a>] Preterm infants are often deficient in levocarnitine and require supplementation.[<a class="bibr" href="#LM947.REF.2" rid="LM947.REF.2">2</a>] No data exist on the safety and efficacy levocarnitine supplementation in nursing mothers or infants without carnitine deficiency. Levocarnitine and its derivatives are generally well tolerated in adults with occasional gastrointestinal upset and restlessness. A fishy odor to the breath, sweat and urine has been reported. Although data are very limited, poor bioavailability might limit absorption by the breastfed infant. It appears unlikely that maternal levocarnitine supplements during nursing would be harmful to the infant, but until more data are available, it is probably best to avoid levocarnitine supplementation unless a healthcare professional prescribes it.</p></div><div id="LM947.Drug_Levels"><h3>Drug Levels</h3><p>Levocarnitine and acetlycarnitine are normal components of breastmilk, and are transported into milk via organic cation transporters.[<a class="bibr" href="#LM947.REF.3" rid="LM947.REF.3">3</a>] As of the revision date, no published information was found regarding breastmilk levels following levocarnitine used as a dietary supplement by nursing mothers.</p><p><i>Maternal Levels.</i> A woman diagnosed with carnitine uptake deficiency following the birth of her infant was given oral carnitine 500 mg 3 times daily. This dose failed to increase her breastmilk carnitine concentration, with a persistently low concentration of 3.4 mg/L (21 micromoles/L) before supplementation and after 18 days of supplementation.[<a class="bibr" href="#LM947.REF.1" rid="LM947.REF.1">1</a>]</p><p>The carnitine concentration was measured in the breastmilk of 27 normal mothers who were not taking carnitine as a supplement. Average carnitine concentrations were 10.1 mg/L over the first 21 days postpartum, which was higher than the maternal serum concentration. The concentration decreased by about 50% by postpartum days 40 to 50. No difference in concentration was found between fore- and hindmilk.[<a class="bibr" href="#LM947.REF.4" rid="LM947.REF.4">4</a>] Another study in normal mothers found a similar average carnitine concentration of 10.6 mg/L.[<a class="bibr" href="#LM947.REF.5" rid="LM947.REF.5">5</a>]</p><p>In a study that followed 37 healthy, nonsmoking mothers who were not taking carnitine as a supplement, carnitine and acetylcarnitine in breastmilk were measured over time. Immediately postpartum, the average milk carnitine concentration was 12.6 mg/L and acetylcarnitine was 5.7 mg/L. From 2 months postpartum to 12 months postpartum, carnitine and acetylcarnitine milk concentrations were lower, in the range of 6.1 to 8.9 mg/L for carnitine and 1.2 to 2 mg/L for acetylcarnitine.[<a class="bibr" href="#LM947.REF.6" rid="LM947.REF.6">6</a>]</p><p>Ten mothers of full-term infants and mothers of preterm infants (36 weeks gestation or less) provided blood and milk samples for measurement of carnitine at 4 times during the first month postpartum. None were taking carnitine as a supplement. In the mothers of full-term infants, total breastmilk carnitine averaged 11.7 mg/L at 2 to 3 days postpartum, 11.8 mg/L at 5 to 7 days postpartum, 11.3 mg/L at 2 weeks postpartum, and 10.5 mg/L at 4 weeks postpartum. About one-third to one-half of the carnitine was free carnitine and the remainder was acetylcarnitine. Breastmilk concentrations were about 50 to 100% greater than simultaneous plasma concentrations. The mothers of preterm infants had higher breastmilk carnitine levels, averaging about 12 mg/L throughout the first month postpartum.[<a class="bibr" href="#LM947.REF.7" rid="LM947.REF.7">7</a>]</p><p>Carnitine and acetylcarnitine were measured in the breastmilk of 14 lactating women who were 1 to 10 months postpartum and not taking carnitine as a supplement. The average milk concentration of free carnitine was 5.9 mg/L and of total carnitine was 7.2 mg/L. Maternal dietary intake of carnitine had no effect on breastmilk carnitine concentrations. The authors estimated that an exclusively breastfed infant would receive about 6 mg daily of carnitine from breastmilk.[<a class="bibr" href="#LM947.REF.8" rid="LM947.REF.8">8</a>]</p><p><i>Infant Levels.</i> A retrospective study of 12,000 (6,000 male and 6,000 female) breastfed neonates in Greece found that carnitine and it various esters in the serum of 3-day-old infants was related to their birth weight. In general, levels of carnitine and its esters increased with increasing birthweight, although the differences between birthweight groups varied by ester.[<a class="bibr" href="#LM947.REF.9" rid="LM947.REF.9">9</a>]</p></div><div id="LM947.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM947.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM947.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="LM947.REF.1">Studinski
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AL, Pino
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GB, Grycki
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E, et al.
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Correlation of plasma and breast milk carnitine levels and the effect of carnitine supplementation in a lactating woman with carnitine uptake deficiency (CUD).
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Mol Genet Metab
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2011;102:315. doi:10.1016/j.ymgme.2010.11.160 [<a href="http://dx.crossref.org/10.1016/j.ymgme.2010.11.160" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">CrossRef</a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="LM947.REF.2">Pekala
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J, Patkowska-Sokola
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B, Bodkowski
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R, et al.
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L-carnitine - Metabolic functions and meaning in humans life.
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Curr Drug Metab
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2011;12:667-78.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/21561431" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21561431</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="LM947.REF.3">Kwok
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B, Yamauchi
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A, Rajesan
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R, et al.
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Carnitine/xenobiotics transporters in the human mammary gland epithelia, MCF12A.
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Am J Physiol Regul Integr Comp Physiol
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2006;290:R793-802.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/16195500" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16195500</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>4.</dt><dd><div class="bk_ref" id="LM947.REF.4">Sandor
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A, Pecsuvac
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K, Kerner
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J, et al.
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On carnitine content of the human breast milk.
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Pediatr Res
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1982;16:89-91.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/7058085" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 7058085</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>5.</dt><dd><div class="bk_ref" id="LM947.REF.5">Cederblad
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G, Svenningsen
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N. Plasma carnitine and breast milk carnitine intake in premature infants.
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J Pediatr Gastroenterol Nutr
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1986;5:616-21.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/3735012" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 3735012</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>6.</dt><dd><div class="bk_ref" id="LM947.REF.6">Rovamo
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LM, Salmenpera
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L, Arjomaa
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P, et al.
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Carnitine during prolonged breast feeding.
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Pediatr Res
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1986;20:806-9.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/3737295" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 3737295</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>7.</dt><dd><div class="bk_ref" id="LM947.REF.7">Penn
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D, Dolderer
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M, Schmidt-Sommerfeld
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E. Carnitine concentrations in the milk of different species and infant formulas.
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Biol Neonate
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1987;52:70-9.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/3651516" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 3651516</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>8.</dt><dd><div class="bk_ref" id="LM947.REF.8">Mitchell
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ME, Snyder
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EA. Dietary carnitine effects on carnitine concentrations in urine and milk in lactating women.
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Am J Clin Nutr
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1991;54:814-20.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/1951151" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 1951151</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>9.</dt><dd><div class="bk_ref" id="LM947.REF.9">Manta-Vogli
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PD, Schulpis
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KH, Loukas
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YL, et al.
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Perinatal free carnitine and short chain acylcarnitine blood concentrations in 12,000 full-term breastfed newborns in relation to their birth weight.
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Pediatr Neonatol
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2020;61:620-8.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/32771364" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 32771364</span></a>]</div></dd></dl></dl></div></div><div id="LM947.Substance_Identification"><h2 id="_LM947_Substance_Identification_">Substance Identification</h2><div id="LM947.Substance_Name"><h3>Substance Name</h3><p>Levocarnitine</p></div><div id="LM947.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>541-15-1; 3040-38-8; 17298-37-2</p></div><div id="LM947.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Complementary Therapies</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK501864_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">October 15, 2024</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Levocarnitine. [Updated 2024 Oct 15].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/lactmed/LM156/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/lactmed/LM702/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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