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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Cranberry - Drugs and Lactation Database (LactMed®) - NCBI Bookshelf</title>
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<meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]">
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<meta name="citation_title" content="Cranberry">
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<meta name="citation_publisher" content="National Institute of Child Health and Human Development">
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<meta name="citation_date" content="2022/04/18">
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<meta name="citation_pmid" content="30000897">
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<meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK501837/">
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<meta name="citation_keywords" content="Cranberry">
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<meta name="citation_keywords" content="Cranberry juice">
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<meta name="citation_keywords" content="Cranberry Extract">
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<meta name="citation_keywords" content="American cranberry">
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<meta name="citation_keywords" content="Mountain Cranberry">
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<meta name="citation_keywords" content="Vaccinium macrocarpon">
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<meta name="citation_keywords" content="Vaccinium macrocarpon, ext.">
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<meta name="citation_keywords" content="UNII-Y74M3X3345">
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<meta name="citation_keywords" content="EINECS 294-875-8">
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<meta name="citation_keywords" content="Y74M3X3345">
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<meta name="citation_keywords" content="Cranberry (Vaccinium macrocarpon) Extract or Concentrate">
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<meta name="citation_keywords" content="Cranberry (Vaccinium macrocarpon) Extract or Concentrate [berry]">
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<meta name="citation_keywords" content="91770-88-6">
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<meta name="DC.Title" content="Cranberry">
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<meta name="DC.Publisher" content="National Institute of Child Health and Human Development">
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<meta name="DC.Date" content="2022/04/18">
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<meta name="description" content="Cranberry (Vaccinium macrocarpon) fruit contains phenolics, flavonoids, anthocyanidins, and ellagitannins. Some products are standardized based on quinic acid and others are standardized based on phenolics. Cranberry is most often used for prevention of urinary tract infections. It has no specific lactation-related uses. Cranberries appear to increase the milk content of polyphenols and total antioxidant capacity. Cranberry preparations are well tolerated as a food, although stomach discomfort and diarrhea can occur with large doses. Cranberry should be avoided in patients allergic to cranberries, blueberries and other Vaccinium species. Some cases of elevated INR have been reported in patients taking cranberry and warfarin.">
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<meta name="og:title" content="Cranberry">
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<meta name="og:description" content="Cranberry (Vaccinium macrocarpon) fruit contains phenolics, flavonoids, anthocyanidins, and ellagitannins. Some products are standardized based on quinic acid and others are standardized based on phenolics. Cranberry is most often used for prevention of urinary tract infections. It has no specific lactation-related uses. Cranberries appear to increase the milk content of polyphenols and total antioxidant capacity. Cranberry preparations are well tolerated as a food, although stomach discomfort and diarrhea can occur with large doses. Cranberry should be avoided in patients allergic to cranberries, blueberries and other Vaccinium species. Some cases of elevated INR have been reported in patients taking cranberry and warfarin.">
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class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK501837_"><span class="title" itemprop="name">Cranberry</span></h1><p class="fm-aai"><a href="#_NBK501837_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 2 minutes</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><p>CASRN: 91770-88-6</p><div id="LM922.Drug_Levels_and_Effects"><h2 id="_LM922_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM922.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Cranberry (<i>Vaccinium macrocarpon</i>) fruit contains phenolics, flavonoids, anthocyanidins, and ellagitannins. Some products are standardized based on quinic acid and others are standardized based on phenolics. Cranberry is most often used for prevention of urinary tract infections. It has no specific lactation-related uses. Cranberries appear to increase the milk content of polyphenols and total antioxidant capacity. Cranberry preparations are well tolerated as a food, although stomach discomfort and diarrhea can occur with large doses. Cranberry should be avoided in patients allergic to cranberries, blueberries and other Vaccinium species. Some cases of elevated INR have been reported in patients taking cranberry and warfarin.</p><p>Dietary supplements do not require extensive pre-marketing approval from the U.S. Food and Drug Administration. Manufacturers are responsible to ensure the safety, but do not need to <i>prove</i> the safety and effectiveness of dietary supplements before they are marketed. Dietary supplements may contain multiple ingredients, and differences are often found between labeled and actual ingredients or their amounts. A manufacturer may contract with an independent organization to verify the quality of a product or its ingredients, but that does <i>not</i> certify the safety or effectiveness of a product. Because of the above issues, clinical testing results on one product may not be applicable to other products. More detailed information <a href="/books/n/lactmed/LactMedDietarySupps/?report=reader">about dietary supplements</a> is available elsewhere on the LactMed Web site.</p></div><div id="LM922.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Relevant published information was not found as of the revision date.</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM922.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM922.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Thirty nursing women, 15 with mastitis and 15 without mastitis, were administered cranberries 20 grams daily for 21 days. Another 30 women, 15 with mastitis and 15 without mastitis, did not receive cranberries and served as a control group. Two samples of mature milk were obtained from each mother, one at the beginning of the study and another at the end. Total antioxidant activity was higher at the beginning of the study in milk from the women with mastitis group compared to those without mastitis. With antibiotic treatment, the total antioxidant capacity was similar to control women at the end of the study. In both the control and mastitis groups, the women who receive cranberry supplementation had higher total antioxidant capacity than those who did not. Cranberry supplementation also increased total polyphenol levels in milk both in women with and without mastitis, although the difference from baseline was only statistically significant for those with mastitis. Cranberry supplementation had no effect on milk levels of glutathione or glutathione peroxide.[<a class="bibr" href="#LM922.REF.1" rid="LM922.REF.1">1</a>]</p></div><div id="LM922.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="LM922.REF.1">Valls-Bellés V, Abad C, Hernández-Aguilar MT, et al. Human milk antioxidative modifications in mastitis: Further beneficial effects of cranberry supplementation. <span><span class="ref-journal">Antioxidants. </span>2022;<span class="ref-vol">11</span>:51.</span> [<a href="/pmc/articles/PMC8772773/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC8772773</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/35052555" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 35052555</span></a>]</div></dd></dl></dl></div></div><div id="LM922.Substance_Identification"><h2 id="_LM922_Substance_Identification_">Substance Identification</h2><div id="LM922.Substance_Name"><h3>Substance Name</h3><p>Cranberry</p></div><div id="LM922.Scientific_Name"><h3>Scientific Name</h3><p>Vaccinium macrocarpon</p></div><div id="LM922.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>91770-88-6</p></div><div id="LM922.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Complementary Therapies</p><p>Food</p><p>Phytotherapy</p><p>Plants, Medicinal</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK501837_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">April 18, 2022</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Cranberry. [Updated 2022 Apr 18].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/lactmed/Covid_vaccines/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/lactmed/LM937/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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