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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]" /><meta name="citation_title" content="Barley" /><meta name="citation_publisher" content="National Institute of Child Health and Human Development" /><meta name="citation_date" content="2024/08/15" /><meta name="citation_pmid" content="30000887" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK501827/" /><meta name="citation_keywords" content="Barley" /><meta name="citation_keywords" content="Hordeum vulgare" /><meta name="citation_keywords" content="Hordeum distychum" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Barley" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Child Health and Human Development" /><meta name="DC.Date" content="2024/08/15" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK501827/" /><meta name="description" content="Barley (Hordeum vulgare) contains starch, dietary fiber such as beta-glucan, and the enzyme diastase. Barley is a purported galactogogue and is used by mothers in many cultures to increase their milk supply.[1-6] Some animal evidence indicates that a polysaccharide in barley can increase serum prolactin,[5,7,8] and one human study supports some galactogogue activity of barley malt and lemon balm in mothers of preterm infants.[9] Galactogogues should never replace evaluation and counseling on modifiable factors that affect milk production.[10,11] No data exist on the excretion of any components of barley into breastmilk, or on the efficacy of barley as a galactogogue. Barley is safe to be consumed during breastfeeding, except by persons with celiac disease. Allergy to barley occurs rarely." /><meta name="og:title" content="Barley" /><meta name="og:type" content="book" /><meta name="og:description" content="Barley (Hordeum vulgare) contains starch, dietary fiber such as beta-glucan, and the enzyme diastase. Barley is a purported galactogogue and is used by mothers in many cultures to increase their milk supply.[1-6] Some animal evidence indicates that a polysaccharide in barley can increase serum prolactin,[5,7,8] and one human study supports some galactogogue activity of barley malt and lemon balm in mothers of preterm infants.[9] Galactogogues should never replace evaluation and counseling on modifiable factors that affect milk production.[10,11] No data exist on the excretion of any components of barley into breastmilk, or on the efficacy of barley as a galactogogue. Barley is safe to be consumed during breastfeeding, except by persons with celiac disease. Allergy to barley occurs rarely." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK501827/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-lactmed-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/lactmed/LM913/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK501827/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK501827_"><span class="title" itemprop="name">Barley</span></h1><p class="small">Last Revision: <span itemprop="dateModified">August 15, 2024</span>.</p><p><em>Estimated reading time: 3 minutes</em></p></div><div class="body-content whole_rhythm" itemprop="text"><div id="LM913.Drug_Levels_and_Effects"><h2 id="_LM913_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM913.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Barley (<i>Hordeum vulgare</i>) contains starch, dietary fiber such as beta-glucan, and the enzyme diastase. Barley is a purported galactogogue and is used by mothers in many cultures to increase their milk supply.[<a class="bk_pop" href="#LM913.REF.1">1</a>-<a class="bk_pop" href="#LM913.REF.6">6</a>] Some animal evidence indicates that a polysaccharide in barley can increase serum prolactin,[<a class="bk_pop" href="#LM913.REF.5">5</a>,<a class="bk_pop" href="#LM913.REF.7">7</a>,<a class="bk_pop" href="#LM913.REF.8">8</a>] and one human study supports some galactogogue activity of barley malt and lemon balm in mothers of preterm infants.[<a class="bk_pop" href="#LM913.REF.9">9</a>] Galactogogues should never replace evaluation and counseling on modifiable factors that affect milk production.[<a class="bk_pop" href="#LM913.REF.10">10</a>,<a class="bk_pop" href="#LM913.REF.11">11</a>] No data exist on the excretion of any components of barley into breastmilk, or on the efficacy of barley as a galactogogue. Barley is safe to be consumed during breastfeeding, except by persons with celiac disease. Allergy to barley occurs rarely.</p><p>Dietary supplements do not require extensive pre-marketing approval from the U.S. Food and Drug Administration. Manufacturers are responsible to ensure the safety, but do not need to <i>prove</i> the safety and effectiveness of dietary supplements before they are marketed. Dietary supplements may contain multiple ingredients, and differences are often found between labeled and actual ingredients or their amounts. A manufacturer may contract with an independent organization to verify the quality of a product or its ingredients, but that does <i>not</i> certify the safety or effectiveness of a product. Because of the above issues, clinical testing results on one product may not be applicable to other products. More detailed information <a href="/books/n/lactmed/LactMedDietarySupps/">about dietary supplements</a> is available elsewhere on the LactMed Web site.</p></div><div id="LM913.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Relevant published information was not found as of the revision date.</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM913.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM913.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Studies in animals indicate that a polysaccharide found in barley is apparently responsible for an increase in prolactin after beer ingestion.[<a class="bk_pop" href="#LM913.REF.5">5</a>,<a class="bk_pop" href="#LM913.REF.7">7</a>,<a class="bk_pop" href="#LM913.REF.8">8</a>] Refer to the LactMed record on <a href="/books/n/lactmed/LM584/">Alcohol</a> for details.</p><p>A double-blind study compared a commercial galactogogue product (Femaltiker, Nutropharma Llc., Poland) containing barley malt, 70% barley glucan and powdered lemon balm (<i>Melissa officinalis</i>) leaves to an identical placebo in the mothers of preterm infants. Mothers took one packet twice a day for 2 weeks, starting within 3 days of delivery. Milk volume was measured by mothers after extraction using an electric breast pump. Forty mothers in each group completed the study. On day 14 of the study the mothers in the barley group produced more milk than the mothers taking placebo (average 95 mL vs 62.5 mL). The total milk volume over the 2-week period was also greater in the active group compared to the placebo group (average 6036 mL vs 4209 mL).[<a class="bk_pop" href="#LM913.REF.9">9</a>] The study had a rather high dropout rate and the results were not subjected to intention-to-treat analysis.</p></div><div id="LM913.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="LM913.REF.1">Chaudhuri
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RN, Ghosh
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BN, Chatterjee
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BN. Diet intake patterns of non-Bengali Muslim mothers during pregnancy and lactation.
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Indian J Public Health
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1989;33:82-3.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/2641755" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 2641755</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="LM913.REF.2">Yarnell
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E.
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Botanical medicine in pregnancy and lactation.
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Altern Complement Ther
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1997;3 (April):93-100. doi:10.1089/act.1997.3.93 [<a href="http://dx.crossref.org/10.1089/act.1997.3.93" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">CrossRef</a>]</div></dd><dt>3.</dt><dd><div class="bk_ref" id="LM913.REF.3">Scott
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CR, Jacobson
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H. A selection of international nutritional and herbal remedies for breastfeeding concerns.
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Midwifery Today Int Midwife
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2005;75:38-9.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/16320878" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16320878</span></a>]</div></dd><dt>4.</dt><dd><div class="bk_ref" id="LM913.REF.4">Winterfeld
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U, Meyer
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Y, Panchaud
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A, et al.
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Management of deficient lactation in Switzerland and Canada: A survey of midwives' current practices.
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Breastfeed Med
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2012;7:317-8.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/22224508" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 22224508</span></a>]</div></dd><dt>5.</dt><dd><div class="bk_ref" id="LM913.REF.5">Sawadogo L, Thibault JF, Rouau X, et al. The lactogenic action of plant extracts. In, Martinet J, Houdebine LM, Herbert H, eds. Biology of lactation. Paris. Institut National de la Research Agrono. 1999:553-64.</div></dd><dt>6.</dt><dd><div class="bk_ref" id="LM913.REF.6">Erarslan
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ZB, Kültür
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S. Medicinal plants traditionally used to increase breast milk in Turkey: An ethnobotanical review.
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J Herbal Med
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2024;44:100849. doi:10.1016/j.hermed.2024.100849 [<a href="http://dx.crossref.org/10.1016/j.hermed.2024.100849" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">CrossRef</a>]</div></dd><dt>7.</dt><dd><div class="bk_ref" id="LM913.REF.7">Sawagado
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L, Houdebine
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LM. Identification of the lactogenic compound present in beer.
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Ann Biol Clin (Paris)
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1988;46:129-34.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/3382062" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 3382062</span></a>]</div></dd><dt>8.</dt><dd><div class="bk_ref" id="LM913.REF.8">Koletzko
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B, Lehner
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F.
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Beer and breastfeeding.
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Adv Exp Med Biol
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2000;478:23-8.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/11065057" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11065057</span></a>]</div></dd><dt>9.</dt><dd><div class="bk_ref" id="LM913.REF.9">Wesolowska
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A, Pietrzak
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B, Kociszewska-Najman
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B, et al.
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Barley malt-based composition as a galactagogue - a randomized, controlled trial in preterm mothers.
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Ginekol Pol
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2021;92:118-25.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/33751522" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 33751522</span></a>]</div></dd><dt>10.</dt><dd><div class="bk_ref" id="LM913.REF.10">Brodribb W. ABM Clinical Protocol #9: Use of galactogogues in initiating or augmenting maternal milk production, second revision 2018.
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Breastfeed Med
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2018;13:307-14.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/29902083" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 29902083</span></a>]</div></dd><dt>11.</dt><dd><div class="bk_ref" id="LM913.REF.11">Breastfeeding challenges: ACOG Committee Opinion, Number 820.
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Obstet Gynecol
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2021;137:e42-e53.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/33481531" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 33481531</span></a>]</div></dd></dl></div></div><div id="LM913.Substance_Identification"><h2 id="_LM913_Substance_Identification_">Substance Identification</h2><div id="LM913.Substance_Name"><h3>Substance Name</h3><p>Barley</p></div><div id="LM913.Scientific_Name"><h3>Scientific Name</h3><p>Hordeum vulgare; Hordeum distychum</p></div><div id="LM913.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Complementary Therapies</p><p>Food</p><p>Galactogogues</p><p>Phytotherapy</p><p>Plants, Medicinal</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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