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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]" /><meta name="citation_title" content="Rilpivirine" /><meta name="citation_publisher" content="National Institute of Child Health and Human Development" /><meta name="citation_date" content="2024/07/15" /><meta name="citation_pmid" content="30000877" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK501818/" /><meta name="citation_keywords" content="Rilpivirine" /><meta name="citation_keywords" content="Edurant" /><meta name="citation_keywords" content="Complera" /><meta name="citation_keywords" content="Juluca" /><meta name="citation_keywords" content="Odefsey" /><meta name="citation_keywords" content="Cabenuva" /><meta name="citation_keywords" content="TMC278" /><meta name="citation_keywords" content="TMC 278" /><meta name="citation_keywords" content="UNII-FI96A8X663" /><meta name="citation_keywords" content="TMC-278" /><meta name="citation_keywords" content="HSDB 8153" /><meta name="citation_keywords" content="FI96A8X663" /><meta name="citation_keywords" content="R278474" /><meta name="citation_keywords" content="R 278474" /><meta name="citation_keywords" content="4-((4-((4-((1E)-2-Cyanoethenyl)-2,6-dimethylphenyl)amino)-2-pyrimidinyl)amino)benzonitrile" /><meta name="citation_keywords" content="Benzonitrile, 4-((4-((4-((1E)-2-cyanoethenyl)-2,6-dimethylphenyl)amino)-2-pyrimidinyl)amino)-" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Rilpivirine" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Child Health and Human Development" /><meta name="DC.Date" content="2024/07/15" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK501818/" /><meta name="description" content="Limited information indicates that maternal rilpivirine doses of 25 mg daily produce low levels in milk and infant serum. Until more data become available, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. Achieving and maintaining viral suppression with antiretroviral therapy decreases breastfeeding transmission risk to less than 1%, but not zero. Individuals with HIV who are on antiretroviral therapy with a sustained undetectable viral load and who choose to breastfeed should be supported in this decision. If a viral load is not suppressed, banked pasteurized donor milk or formula is recommended.[1,2]" /><meta name="og:title" content="Rilpivirine" /><meta name="og:type" content="book" /><meta name="og:description" content="Limited information indicates that maternal rilpivirine doses of 25 mg daily produce low levels in milk and infant serum. Until more data become available, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. Achieving and maintaining viral suppression with antiretroviral therapy decreases breastfeeding transmission risk to less than 1%, but not zero. Individuals with HIV who are on antiretroviral therapy with a sustained undetectable viral load and who choose to breastfeed should be supported in this decision. If a viral load is not suppressed, banked pasteurized donor milk or formula is recommended.[1,2]" /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK501818/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-lactmed-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/lactmed/LM905/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK501818/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK501818_"><span class="title" itemprop="name">Rilpivirine</span></h1><p class="small">Last Revision: <span itemprop="dateModified">July 15, 2024</span>.</p><p><em>Estimated reading time: 1 minute</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 500287-72-9</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/135246698" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=135246698" alt="image 135246698 in the ncbi pubchem database" /></a><div id="LM905.Drug_Levels_and_Effects"><h2 id="_LM905_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM905.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Limited information indicates that maternal rilpivirine doses of 25 mg daily produce low levels in milk and infant serum. Until more data become available, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. Achieving and maintaining viral suppression with antiretroviral therapy decreases breastfeeding transmission risk to less than 1%, but not zero. Individuals with HIV who are on antiretroviral therapy with a sustained undetectable viral load and who choose to breastfeed should be supported in this decision. If a viral load is not suppressed, banked pasteurized donor milk or formula is recommended.[<a class="bk_pop" href="#LM905.REF.1">1</a>,<a class="bk_pop" href="#LM905.REF.2">2</a>]</p></div><div id="LM905.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Two mothers taking rilpivirine 25 mg once daily provided milk samples at a median of 15.5 hours after a dose. The mean drug concentration in milk was 123 mcg/L, which resulted in an estimated infant dosage of 20 mcg/kg daily.[<a class="bk_pop" href="#LM905.REF.3">3</a>]</p><p><i>Infant Levels.</i> An infant was breastfed by a mother taking rilpivirine 25 mg once daily, although the extent of breastfeeding was not sated. The infant’s serum concentrations taken 16 hours after maternal drug intake at 1 month of age was 4 mcg/L.[<a class="bk_pop" href="#LM905.REF.3">3</a>]</p></div><div id="LM905.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM905.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM905.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="LM905.REF.1">World Health Organization. Consolidated guidelines on HIV prevention, testing, treatment, service delivery and monitoring: Recommendations for a public health approach. 2021. <a href="https://www.who.int/publications/i/item/9789240031593" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">https://www<wbr style="display:inline-block"></wbr>.who.int/publications<wbr style="display:inline-block"></wbr>/i/item/9789240031593</a> [<a href="https://pubmed.ncbi.nlm.nih.gov/34370423" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 34370423</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="LM905.REF.2">Department of Health and Human Services. Recommendations for the use of antiretroviral drugs during pregnancy and interventions to reduce perinatal HIV transmission in the United States. 2024. <a href="https://clinicalinfo.hiv.gov/sites/default/files/guidelines/documents/perinatal-hiv/guidelines-perinatal.pdf" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">https:<wbr style="display:inline-block"></wbr>//clinicalinfo<wbr style="display:inline-block"></wbr>.hiv.gov/sites/default<wbr style="display:inline-block"></wbr>/files/guidelines/documents<wbr style="display:inline-block"></wbr>/perinatal-hiv<wbr style="display:inline-block"></wbr>/guidelines-perinatal.pdf</a></div></dd><dt>3.</dt><dd><div class="bk_ref" id="LM905.REF.3">Aebi-Popp
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K, Kahlert
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CR, Crisinel
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PA, et al.
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Transfer of antiretroviral drugs into breastmilk: A prospective study from the Swiss Mother and Child HIV Cohort Study.
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J Antimicrob Chemother
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2022;77:3436-42.
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[<a href="/pmc/articles/PMC9704434/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC9704434</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/36177836" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 36177836</span></a>]</div></dd></dl></div></div><div id="LM905.Substance_Identification"><h2 id="_LM905_Substance_Identification_">Substance Identification</h2><div id="LM905.Substance_Name"><h3>Substance Name</h3><p>Rilpivirine</p></div><div id="LM905.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>500287-72-9</p></div><div id="LM905.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Anti-Infective Agents</p><p>Antiviral Agents</p><p>Anti-HIV Agents</p><p>Anti-Retroviral Agents</p><p>Reverse Transcriptase Inhibitors</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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