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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Iobenguane I 131 - Drugs and Lactation Database (LactMed®) - NCBI Bookshelf</title>
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<meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]">
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<meta name="citation_title" content="Iobenguane I 131">
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<meta name="citation_publisher" content="National Institute of Child Health and Human Development">
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<meta name="citation_date" content="2023/10/15">
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<meta name="citation_pmid" content="30000770">
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<meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK501710/">
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<meta name="citation_keywords" content="Azedra">
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<meta name="citation_keywords" content="Iobenguane (131I)">
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<meta name="citation_keywords" content="Iobenguane I 131">
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<meta name="citation_keywords" content="Iobeguane I 131">
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<meta name="citation_keywords" content="3-Iodobenzylguanidine">
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<meta name="citation_keywords" content="Iobenguane I131">
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<meta name="citation_keywords" content="131I-MIBG">
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<meta name="citation_keywords" content="Iobenguano (131 I)">
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<meta name="citation_keywords" content="Iobenguanum (131 I)">
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<meta name="citation_keywords" content="UNII-Q461L7AK4R">
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<meta name="citation_keywords" content="Ultratrace iobenguane I131">
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<meta name="citation_keywords" content="I-131 MIBG">
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<meta name="citation_keywords" content="Iobenguano (131 I) [Spanish]">
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<meta name="citation_keywords" content="Q461L7AK4R">
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<meta name="citation_keywords" content="Iobenguane I 131 [USAN:USP]">
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<meta name="citation_keywords" content="Iobenguane ((sup 131)I)">
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<meta name="citation_keywords" content="Iobenguanum (131 I) [Latin]">
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<meta name="citation_keywords" content="MIBG-(131 I)">
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<meta name="citation_keywords" content="Iobenguane (131I) [INN]">
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<meta name="citation_keywords" content="(m-((sup 131)I)Iodobenzyl)guanidine">
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<meta name="citation_keywords" content="(m-Iodo-(sup 131)I-benzyl)guanidine">
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<meta name="citation_keywords" content="77679-27-7">
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<meta name="citation_keywords" content="Guanidine, ((3-iodo-131I)phenyl)methyl)-">
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<meta name="citation_keywords" content="Guanidine, ((3-(iodo-(sup 131)I)phenyl)methyl)-">
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<meta name="citation_keywords" content="meta-Iodobenzylguanidine (MIBG) labeled with iodine-131">
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<meta name="DC.Title" content="Iobenguane I 131">
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<meta name="DC.Date" content="2023/10/15">
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<meta name="description" content="Information in this record refers to the use of iobenguane I 131 (I 131 meta-iodobenzylguanidine; I 131 MIBG) as a diagnostic agent. International agencies state that breastfeeding should be interrupted for more than 3 weeks following diagnostic use of I 131 MIBG.[1,2]After therapeutic dosages, the manufacturer recommends that breastfeeding should be withheld for 80 days after the final dose. These times usually result in permanent discontinuation of breastfeeding for this infant, and cessation of breastfeeding for the current infant is recommended by most experts.[3-6] Patients receiving iobenguane I 131usually receive potassium iodide prior to the diagnostic examination to block their thyroid glands’ uptake of the I-131 that is released from the I 131 MIBG. Iodide may interfere with the infant’s thyroid function.">
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<meta name="og:description" content="Information in this record refers to the use of iobenguane I 131 (I 131 meta-iodobenzylguanidine; I 131 MIBG) as a diagnostic agent. International agencies state that breastfeeding should be interrupted for more than 3 weeks following diagnostic use of I 131 MIBG.[1,2]After therapeutic dosages, the manufacturer recommends that breastfeeding should be withheld for 80 days after the final dose. These times usually result in permanent discontinuation of breastfeeding for this infant, and cessation of breastfeeding for the current infant is recommended by most experts.[3-6] Patients receiving iobenguane I 131usually receive potassium iodide prior to the diagnostic examination to block their thyroid glands’ uptake of the I-131 that is released from the I 131 MIBG. Iodide may interfere with the infant’s thyroid function.">
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class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK501710_"><span class="title" itemprop="name">Iobenguane I 131</span></h1><p class="fm-aai"><a href="#_NBK501710_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 2 minutes</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><p>CASRN: 77679-27-7</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/135027866" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=135027866" alt="image 135027866 in the ncbi pubchem database" /></a><div id="LM805.Drug_Levels_and_Effects"><h2 id="_LM805_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM805.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Information in this record refers to the use of iobenguane I 131 (I 131 meta-iodobenzylguanidine; I 131 MIBG) as a diagnostic agent. International agencies state that breastfeeding should be interrupted for more than 3 weeks following diagnostic use of I 131 MIBG.[<a class="bibr" href="#LM805.REF.1" rid="LM805.REF.1">1</a>,<a class="bibr" href="#LM805.REF.2" rid="LM805.REF.2">2</a>]After therapeutic dosages, the manufacturer recommends that breastfeeding should be withheld for 80 days after the final dose. These times usually result in permanent discontinuation of breastfeeding for this infant, and cessation of breastfeeding for the current infant is recommended by most experts.[<a class="bibr" href="#LM805.REF.3" rid="LM805.REF.3">3</a>-<a class="bibr" href="#LM805.REF.6" rid="LM805.REF.6">6</a>] Patients receiving iobenguane I 131usually receive potassium iodide prior to the diagnostic examination to block their thyroid glands’ uptake of the I-131 that is released from the I 131 MIBG. Iodide may interfere with the infant’s thyroid function.</p><p>Nursing mothers should not work with substances containing I 131 in their workplace.[<a class="bibr" href="#LM805.REF.7" rid="LM805.REF.7">7</a>]</p></div><div id="LM805.Drug_Levels"><h3>Drug Levels</h3><p>I 131 is a beta and high-energy gamma emitter with a main gamma emission energy of 364 keV and a physical half-life of 8.04 days.[<a class="bibr" href="#LM805.REF.8" rid="LM805.REF.8">8</a>] Iodide is actively secreted into breastmilk and actively taken up by the mother's and infant's thyroid glands.</p></div><div id="LM805.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM805.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM805.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="LM805.REF.1">Mattsson
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S, Johansson
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L, Leide Svegborn
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S, et al.
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Radiation dose to patients from radiopharmaceuticals: A compendium of current information related to frequently used substances. ICRP Publication 128. Annex D. Recommendations on breast-feeding interruptions.
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Ann ICRP
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2015;44 (2
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Suppl):7-321. [<a href="https://pubmed.ncbi.nlm.nih.gov/26069086" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26069086</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="LM805.REF.2">ARSAC notes for guidance: Good clinical practice in nuclear medicine. Notes for guidance on the clinical administration of radiopharmaceuticals and use of sealed radioactive sources. 2020. <a href="https://www.gov.uk/government/publications/arsac-notes-for-guidance" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">https://www<wbr style="display:inline-block"></wbr>​.gov.uk/government<wbr style="display:inline-block"></wbr>​/publications<wbr style="display:inline-block"></wbr>​/arsac-notes-for-guidance</a> [<a href="https://pubmed.ncbi.nlm.nih.gov/10732169" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 10732169</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="LM805.REF.3">Mattsson
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S, Johansson
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L, Leide Svegborn
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S, et al.
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Radiation dose to patients from radiopharmaceuticals: A compendium of current information related to frequently used substances. ICRP Publication 128. Annex D. Recommendations on breast-feeding interruptions.
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Ann ICRP
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2015;44 (2
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Suppl):319-21. [<a href="https://pubmed.ncbi.nlm.nih.gov/26069086" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26069086</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>4.</dt><dd><div class="bk_ref" id="LM805.REF.4">Bombardieri
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E, Giammarile
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F, Aktolun
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C, et al.
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131I/123I-metaiodobenzylguanidine (mIBG) scintigraphy: Procedure guidelines for tumour imaging.
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Eur J Nucl Med Mol Imaging
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2010;37:2436-46. [<a href="https://pubmed.ncbi.nlm.nih.gov/20644928" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 20644928</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>5.</dt><dd><div class="bk_ref" id="LM805.REF.5">International Atomic Energy Agency. Radiation Protection and Safety in Medical Uses of Ionizing Radiation, IAEA Safety Standards Series No. SSG-46, IAEA, Vienna. 2018. <a href="https://www.iaea.org/publications/11102/radiation-protection-and-safety-in-medical-uses-of-ionizing-radiation" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">https://www<wbr style="display:inline-block"></wbr>​.iaea.org<wbr style="display:inline-block"></wbr>​/publications/11102/radiation-protection-and-safety-in-medical-uses-of-ionizing-radiation</a></div></dd></dl><dl class="bkr_refwrap"><dt>6.</dt><dd><div class="bk_ref" id="LM805.REF.6">Taieb
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D, Hicks
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RJ, Hindie
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E, et al.
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European Association of Nuclear Medicine Practice Guideline/Society of Nuclear Medicine and Molecular Imaging Procedure Standard 2019 for radionuclide imaging of phaeochromocytoma and paraganglioma.
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Eur J Nucl Med Mol Imaging
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2019;46:2112-37. [<a href="/pmc/articles/PMC7446938/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC7446938</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/31254038" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 31254038</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>7.</dt><dd><div class="bk_ref" id="LM805.REF.7">Almén
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A, Mattsson
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S. Radiological protection of foetuses and breast-fed children of occupationally exposed women in nuclear medicine - Challenges for hospitals.
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Phys Med
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2017;43:172-7. [<a href="https://pubmed.ncbi.nlm.nih.gov/28882410" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28882410</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>8.</dt><dd><div class="bk_ref" id="LM805.REF.8">Dilsizian V, Metter D, Palestro C, Zanzonico P. Advisory Committee on Medical Uses of Isotopes (ACMUI) Sub-Committee on Nursing Mother Guidelines for the Medical Administration of Radioactive Material. Final report submitted: January 31, 2019. 2019. <a href="https://www.nrc.gov/docs/ML1903/ML19038A498.pdf" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">https://www<wbr style="display:inline-block"></wbr>​.nrc.gov/docs<wbr style="display:inline-block"></wbr>​/ML1903/ML19038A498.pdf</a></div></dd></dl></dl></div></div><div id="LM805.Substance_Identification"><h2 id="_LM805_Substance_Identification_">Substance Identification</h2><div id="LM805.Substance_Name"><h3>Substance Name</h3><p>Iobenguane I 131</p></div><div id="LM805.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>77679-27-7</p></div><div id="LM805.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Radiopharmaceuticals</p><p>Iodine Radioisotopes</p><p>Diagnostic Agents</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK501710_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">October 15, 2023</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Iobenguane I 131. [Updated 2023 Oct 15].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/lactmed/LM668/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/lactmed/LM1144/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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