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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK501704_"><span class="title" itemprop="name">Dalteparin</span></h1><p class="small">Last Revision: <span itemprop="dateModified">November 15, 2024</span>.</p><p><em>Estimated reading time: 1 minute</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 9041-08-1</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/53787074" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=53787074" alt="image 53787074 in the ncbi pubchem database" /></a><div id="LM80.Drug_Levels_and_Effects"><h2 id="_LM80_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM80.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Because of the low levels of dalteparin in breastmilk and its large molecular weight of 2000 to 9000 daltons, amounts ingested by the infant are small and it would not be expected to be absorbed from breastmilk by the infant. No special precautions are required.[<a class="bk_pop" href="#LM80.REF.1">1</a>]</p></div><div id="LM80.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> In two women receiving subcutaneous dalteparin 5000 IU and 10,000 IU daily, respectively, dalteparin was undetectable in breastmilk.[<a class="bk_pop" href="#LM80.REF.2">2</a>]</p><p>Anti-Xa activity (a measurement of anticoagulant activity) was measured in the milk of 15 patients before and 3 to 4 hours after 4 to 8 days at a daily dosage of 2500 IU subcutaneously. Anti-Xa activity in milk ranged from less than 5 to 37 IU/L which was 2.5 to 22.4% of the simultaneous maternal plasma anti-Xa activity.[<a class="bk_pop" href="#LM80.REF.3">3</a>]</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM80.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Although not clearly stated, it appears that 15 neonates were breastfed during maternal dalteparin use in one study with no adverse effects reported.[<a class="bk_pop" href="#LM80.REF.3">3</a>]</p><p>In another report, one mother breastfed her infant for 20 days starting at 7 weeks of age while taking subcutaneous dalteparin 5000 IU subcutaneously twice daily with no adverse effects to her infant.[<a class="bk_pop" href="#LM80.REF.4">4</a>]</p></div><div id="LM80.Effects_on_Lactation_and_Breastmilk"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM80.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p><a href="/books/n/lactmed/LM619/">Acenocoumarol</a>, <a href="/books/n/lactmed/LM104/">Enoxaparin</a>, <a href="/books/n/lactmed/LM133/">Heparin</a>, <a href="/books/n/lactmed/LM1169/">Rivaroxaban</a>, <a href="/books/n/lactmed/LM279/">Warfarin</a></p></div><div id="LM80.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="LM80.REF.1">Bates
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SM, Rajasekhar
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A, Middeldorp
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S, et al.
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American Society of Hematology 2018 guidelines for management of venous thromboembolism: Venous thromboembolism in the context of pregnancy.
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Blood Adv
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2018;2:3317-59.
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[<a href="/pmc/articles/PMC6258928/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC6258928</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/30482767" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 30482767</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="LM80.REF.2">Harenberg
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J, Leber
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G, Zimmermann
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R, et al.
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[Prevention of thromboembolism with low-molecular weight heparin in pregnancy]. Geburtshilfe Frauenheilkd
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1987;47:15-8.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/3569823" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 3569823</span></a>]</div></dd><dt>3.</dt><dd><div class="bk_ref" id="LM80.REF.3">Richter
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C, Sitzmann
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J, Lang
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P, et al.
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Excretion of low molecular weight heparin in human milk.
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Br J Clin Pharmacol
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2001;52:708-10.
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[<a href="/pmc/articles/PMC2014571/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC2014571</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/11736885" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11736885</span></a>]</div></dd><dt>4.</dt><dd><div class="bk_ref" id="LM80.REF.4">Lindhoff-Last
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E, Willeke
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A, Thalhammer
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C, et al.
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Hirudin treatment in a breastfeeding woman.
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Lancet
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2000;355:467-8.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/10841132" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 10841132</span></a>]</div></dd></dl></div></div><div id="LM80.Substance_Identification"><h2 id="_LM80_Substance_Identification_">Substance Identification</h2><div id="LM80.Substance_Name"><h3>Substance Name</h3><p>Dalteparin</p></div><div id="LM80.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Anticoagulants</p><p>Low Molecular Weight Heparin</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div><div class="small"><span class="label">Bookshelf ID: NBK501704</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/30000764" title="PubMed record of this page" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">30000764</a></span></div><div style="margin-top:2em" class="bk_noprnt"><a class="bk_cntns" href="/books/n/lactmed/">Contents</a><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/lactmed/LM1488/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/lactmed/LM954/" title="Next page in this title">Next ></a></div></div></div></div>
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