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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]" /><meta name="citation_title" content="Carbachol" /><meta name="citation_publisher" content="National Institute of Child Health and Human Development" /><meta name="citation_date" content="2021/04/19" /><meta name="citation_pmid" content="30000716" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK501655/" /><meta name="citation_keywords" content="carbachol" /><meta name="citation_keywords" content="Miostat" /><meta name="citation_keywords" content="Carbamoylcholine chloride" /><meta name="citation_keywords" content="Carbacholine" /><meta name="citation_keywords" content="Carbocholine" /><meta name="citation_keywords" content="Jestryl" /><meta name="citation_keywords" content="Doryl" /><meta name="citation_keywords" content="Carbacholin" /><meta name="citation_keywords" content="Carbacholum" /><meta name="citation_keywords" content="Carbacolina" /><meta name="citation_keywords" content="Carbamiotin" /><meta name="citation_keywords" content="Carbocholin" /><meta name="citation_keywords" content="Carbastat" /><meta name="citation_keywords" content="Carbochol" /><meta name="citation_keywords" content="Carcholin" /><meta name="citation_keywords" content="Karbachol" /><meta name="citation_keywords" content="Vasoperif" /><meta name="citation_keywords" content="Coletyl" /><meta name="citation_keywords" content="Carbyl" /><meta name="citation_keywords" content="Lentin" /><meta name="citation_keywords" content="Isopto Carbachol" /><meta name="citation_keywords" content="Moryl" /><meta name="citation_keywords" content="Carbacol" /><meta name="citation_keywords" content="Rilentol" /><meta name="citation_keywords" content="Carbamylcholine chloride" /><meta name="citation_keywords" content="Carbacholinum" /><meta name="citation_keywords" content="Carbach" /><meta name="citation_keywords" content="Lentine" /><meta name="citation_keywords" content="Mistura C" /><meta name="citation_keywords" content="Carbacholine chloride" /><meta name="citation_keywords" content="CARBACHOL CHLORIDE" /><meta name="citation_keywords" content="Carbacolo" /><meta name="citation_keywords" content="Choline carbamate chloride" /><meta name="citation_keywords" content="P. 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Carbachol" /><meta name="citation_keywords" content="Karbamoylcholin chlorid" /><meta name="citation_keywords" content="Lentine [French]" /><meta name="citation_keywords" content="Choline chlorine carbamate" /><meta name="citation_keywords" content="Doryl (pharmaceutical)" /><meta name="citation_keywords" content="Karbachol [Czech]" /><meta name="citation_keywords" content="Carbacolo [DCIT]" /><meta name="citation_keywords" content="Carbachol hydrochloride" /><meta name="citation_keywords" content="Carbaminocholine chloride" /><meta name="citation_keywords" content="Carbacholum chloratum" /><meta name="citation_keywords" content="Carbacholini chloridum" /><meta name="citation_keywords" content="Choline chloride, carbamate" /><meta name="citation_keywords" content="Doryl (VAN)" /><meta name="citation_keywords" content="Carbaminoylcholine chloride" /><meta name="citation_keywords" content="Carbacholinium chloratum" /><meta name="citation_keywords" content="Carbamoylcholine-hydrochloride" /><meta name="citation_keywords" content="Carbacol [INN-Spanish]" /><meta name="citation_keywords" content="Carbacholum [INN-Latin]" /><meta name="citation_keywords" content="51-83-2" /><meta name="citation_keywords" content="Choline chloride, carbamoyl-" /><meta name="citation_keywords" content="Choline, chloride, carbamate" /><meta name="citation_keywords" content="Karbamoylcholin chlorid [Czech]" /><meta name="citation_keywords" content="gamma-Carbamoyl choline chloride" /><meta name="citation_keywords" content="Choline, chloride carbamate(ester)" /><meta name="citation_keywords" content="UNII-8Y164V895Y" /><meta name="citation_keywords" content="(2-Carbamoyloxyethyl)trimethylammonium chloride" /><meta name="citation_keywords" content="HSDB 6373" /><meta name="citation_keywords" content="(2-Hydroxyethyl)trimethylammonium chloride carbamate" /><meta name="citation_keywords" content="Carbachol [USP:INN:BAN:JAN]" /><meta name="citation_keywords" content="EINECS 200-127-3" /><meta name="citation_keywords" content="NSC 32865" /><meta name="citation_keywords" content="TL 457" /><meta name="citation_keywords" content="(2-Hydroxyethyl)trimethyl ammonium chloride carbamate" /><meta name="citation_keywords" content="Carbamic acid, ester with choline chloride" /><meta name="citation_keywords" content="8Y164V895Y" /><meta name="citation_keywords" content="Choline, chloride, carbamate, hydrochloride" /><meta name="citation_keywords" content="2-((Aminocarbonyl)oxy)-N,N,N-trimethylethanaminum chloride" /><meta name="citation_keywords" content="2-((Aminocarbonyl)oxy)-N,N,N-trimethylethanaminium chloride" /><meta name="citation_keywords" content="Ethanaminium, 2-((aminocarbonyl)oxy)-N,N,N-trimethyl-, chloride" /><meta name="citation_keywords" content="Ethanaminium, 2-(aminocarbonyl)oxy-N,N,N-trimethyl-, chloride" /><meta name="citation_keywords" content="Ethanaminium, 2-((aminocarbonyl)oxy)-N,N,N-trimethyl-, chloride (1:1)" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Carbachol" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Child Health and Human Development" /><meta name="DC.Date" content="2021/04/19" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK501655/" /><meta name="description" content="No information is available on the use of carbachol ophthalmic drops during breastfeeding. Because of its short half-life, it is not likely to reach the bloodstream of the infant or cause any adverse effects in breastfed infants." /><meta name="og:title" content="Carbachol" /><meta name="og:type" content="book" /><meta name="og:description" content="No information is available on the use of carbachol ophthalmic drops during breastfeeding. Because of its short half-life, it is not likely to reach the bloodstream of the infant or cause any adverse effects in breastfed infants." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK501655/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-lactmed-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/lactmed/LM754/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK501655/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK501655_"><span class="title" itemprop="name">Carbachol</span></h1><p class="small">Last Revision: <span itemprop="dateModified">April 19, 2021</span>.</p><p><em>Estimated reading time: 1 minute</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 51-83-2</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134972754" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134972754" alt="image 134972754 in the ncbi pubchem database" /></a><div id="LM754.Drug_Levels_and_Effects"><h2 id="_LM754_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM754.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>No information is available on the use of carbachol ophthalmic drops during breastfeeding. Because of its short half-life, it is not likely to reach the bloodstream of the infant or cause any adverse effects in breastfed infants.</p></div><div id="LM754.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Relevant published information was not found as of the revision date.</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM754.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM754.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information in nursing mothers was not found as of the revision date. In animals, cholinergic drugs increase oxytocin release, and have variable effects on serum prolactin.[<a class="bk_pop" href="#LM754.REF.1">1</a>,<a class="bk_pop" href="#LM754.REF.2">2</a>] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.</p></div><div id="LM754.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="LM754.REF.1">Clarke G, Fall CH, Lincoln DW, et al. Effects of cholinoceptor antagonists on the suckling-induced and experimentally evoked release of oxytocin. <span><span class="ref-journal">Br J Pharmacol. </span>1978;<span class="ref-vol">63</span>:519–27.</span> [<a href="/pmc/articles/PMC1668097/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC1668097</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/566601" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 566601</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="LM754.REF.2">Müller EE, Locatelli V, Cella S, et al. Prolactin-lowering and -releasing drugs: Mechanisms of action and therapeutic applications. <span><span class="ref-journal">Drugs. </span>1983;<span class="ref-vol">25</span>:399–432.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/6133737" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 6133737</span></a>]</div></dd></dl></div></div><div id="LM754.Substance_Identification"><h2 id="_LM754_Substance_Identification_">Substance Identification</h2><div id="LM754.Substance_Name"><h3>Substance Name</h3><p>Carbachol</p></div><div id="LM754.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>51-83-2</p></div><div id="LM754.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Miotics</p><p>Muscarinic Agonists</p><p>Parasympathomimetics</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div><div class="small"><span class="label">Bookshelf ID: NBK501655</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/30000716" title="PubMed record of this page" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">30000716</a></span></div><div style="margin-top:2em" class="bk_noprnt"><a class="bk_cntns" href="/books/n/lactmed/">Contents</a><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/lactmed/LM881/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/lactmed/LM400/" title="Next page in this title">Next ></a></div></div></div></div>
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