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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]" /><meta name="citation_title" content="Doxazosin" /><meta name="citation_publisher" content="National Institute of Child Health and Human Development" /><meta name="citation_date" content="2024/12/15" /><meta name="citation_pmid" content="30000706" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK501645/" /><meta name="citation_keywords" content="doxazosin" /><meta name="citation_keywords" content="Doxazosine" /><meta name="citation_keywords" content="Doxazosina" /><meta name="citation_keywords" content="Doxazosinum" /><meta name="citation_keywords" content="UNII-NW1291F1W8" /><meta name="citation_keywords" content="UK 33274" /><meta name="citation_keywords" content="NW1291F1W8" /><meta name="citation_keywords" content="EC 616-059-6" /><meta name="citation_keywords" content="[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Doxazosin" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Child Health and Human Development" /><meta name="DC.Date" content="2024/12/15" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK501645/" /><meta name="description" content="Limited information indicates that maternal doses of 4 mg daily produce low very levels in milk and would not be expected to cause any adverse effects in breastfed infants." /><meta name="og:title" content="Doxazosin" /><meta name="og:type" content="book" /><meta name="og:description" content="Limited information indicates that maternal doses of 4 mg daily produce low very levels in milk and would not be expected to cause any adverse effects in breastfed infants." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK501645/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-lactmed-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/lactmed/LM745/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK501645/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK501645_"><span class="title" itemprop="name">Doxazosin</span></h1><p class="small">Last Revision: <span itemprop="dateModified">December 15, 2024</span>.</p><p><em>Estimated reading time: 1 minute</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 74191-85-8</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/135011738" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=135011738" alt="image 135011738 in the ncbi pubchem database" /></a><div id="LM745.Drug_Levels_and_Effects"><h2 id="_LM745_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM745.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Limited information indicates that maternal doses of 4 mg daily produce low very levels in milk and would not be expected to cause any adverse effects in breastfed infants.</p></div><div id="LM745.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> A woman who was nursing a 6-month-old infant received 2 doses of doxazosin 4 mg 24 hours apart. Four milk samples were obtained after the second dose. A peak milk level of 4.2 mcg/L occurred at 1 hour after the dose. The average concentration over the 18-hour study period was 2.9 mcg/L. The authors estimated that a fully breastfed infant would receive an average daily dosage of 440 ng/kg daily or about 0.6% of the maternal weight-adjusted dosage.[<a class="bk_pop" href="#LM745.REF.1">1</a>]</p><p>A woman with pheochromocytoma during pregnancy was treated near term with doxazosin and metoprolol. She continued doxazosin for 3 days postpartum until adrenal surgery. Thirty hours after her last dose of 8 mg of doxazosin, the drug was undetectable (<25 mcg/L) in her breastmilk.[<a class="bk_pop" href="#LM745.REF.2">2</a>]</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM745.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM745.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information in nursing mothers was not found as of the revision date. However, the pharmacologically similar drug prazosin does not affect serum prolactin concentration in patients with hypertension,[<a class="bk_pop" href="#LM745.REF.3">3</a>,<a class="bk_pop" href="#LM745.REF.4">4</a>] indicating that doxazosin may not affect prolactin levels. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.</p></div><div id="LM745.Alternate_Drugs"><h3>Alternate Drugs</h3><p>(Hypertension) <a href="/books/n/lactmed/LM727/">Candesartan</a>, <a href="/books/n/lactmed/LM26/">Benazepril</a>, <a href="/books/n/lactmed/LM38/">Captopril</a>, <a href="/books/n/lactmed/LM102/">Enalapril</a>, <a href="/books/n/lactmed/LM160/">Lisinopril</a>, <a href="/books/n/lactmed/LM234/">Quinapril</a>, <a href="/books/n/lactmed/LM137/">Hydrochlorothiazide</a>, <a href="/books/n/lactmed/LM179/">Methyldopa</a>, <a href="/books/n/lactmed/LM301/">Propranolol</a></p></div><div id="LM745.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="LM745.REF.1">Jensen
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BP, Dalrymple
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JM, Begg
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EJ. Transfer of doxazosin into breast milk.
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[corrected in J Hum Lact 2014;30: NP3-NP4]. J Hum Lact
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2013;29:150-3.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/23439864" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 23439864</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="LM745.REF.2">Versmissen
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J, Koch
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BC, Roofthooft
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DW, et al.
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Doxazosin treatment of phaeochromocytoma during pregnancy: Placental transfer and disposition in breast milk.
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Br J Clin Pharmacol
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2016;82:568-9.
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[<a href="/pmc/articles/PMC4972176/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4972176</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/27194370" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27194370</span></a>]</div></dd><dt>3.</dt><dd><div class="bk_ref" id="LM745.REF.3">Barbieri
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C, Caldara
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R, Ferrari
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C, et al.
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Metabolic effects of prazosin.
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Clin Pharmacol Ther
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1980;27:313-6.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/6102000" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 6102000</span></a>]</div></dd><dt>4.</dt><dd><div class="bk_ref" id="LM745.REF.4">Barbieri
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C, Ferrari
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C, Borzio
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M, et al.
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Metabolic effects of chronic prazosin treatment.
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Horm Metab Res
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1980;12:331-4.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/6105121" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 6105121</span></a>]</div></dd></dl></div></div><div id="LM745.Substance_Identification"><h2 id="_LM745_Substance_Identification_">Substance Identification</h2><div id="LM745.Substance_Name"><h3>Substance Name</h3><p>Doxazosin</p></div><div id="LM745.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>74191-85-8</p></div><div id="LM745.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Adrenergic alpha-Antagonists</p><p>Antihypertensive Agents</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div><div class="small"><span class="label">Bookshelf ID: NBK501645</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/30000706" title="PubMed record of this page" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">30000706</a></span></div><div style="margin-top:2em" class="bk_noprnt"><a class="bk_cntns" href="/books/n/lactmed/">Contents</a><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/lactmed/LM851/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/lactmed/LM319/" title="Next page in this title">Next ></a></div></div></div></div>
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