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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Dinoprostone - Drugs and Lactation Database (LactMed®) - NCBI Bookshelf</title>
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<meta name="citation_title" content="Dinoprostone">
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<meta name="citation_keywords" content="Prostaglandin E2">
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<meta name="citation_keywords" content="Dinoprostone">
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<meta name="citation_keywords" content="PGE2">
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<meta name="citation_keywords" content="Prepidil">
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<meta name="citation_keywords" content="Prostin E2">
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<meta name="citation_keywords" content="Cervidil">
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<meta name="citation_keywords" content="Propess">
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<meta name="citation_keywords" content="Dinoproston">
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<meta name="citation_keywords" content="Prostin">
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<meta name="citation_keywords" content="Minprositin E2">
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<meta name="citation_keywords" content="Dinoprostonum">
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<meta name="citation_keywords" content="Minprostin E2">
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<meta name="citation_keywords" content="Cerviprost">
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<meta name="citation_keywords" content="l-Prostaglandin E2">
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<meta name="citation_keywords" content="Cerviprime">
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<meta name="citation_keywords" content="Prostenone">
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<meta name="citation_keywords" content="Enzaprost E">
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<meta name="citation_keywords" content="(15S)-Prostaglandin E2">
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<meta name="citation_keywords" content="363-24-6">
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<meta name="citation_keywords" content="l-PGE2">
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<meta name="citation_keywords" content="NSC 196514">
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<meta name="citation_keywords" content="U 12062">
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<meta name="citation_keywords" content="(Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid">
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class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK501637_"><span class="title" itemprop="name">Dinoprostone</span></h1><p class="fm-aai"><a href="#_NBK501637_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 3 minutes</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><p>CASRN: 363-24-6</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134973974" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134973974" alt="image 134973974 in the ncbi pubchem database" /></a><div id="LM738.Drug_Levels_and_Effects"><h2 id="_LM738_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM738.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Dinoprostone (prostaglandin E2) has not been measured in human milk after exogenous administration, but it is a normal component of breastmilk in small amounts where it may help protect the infant's gastrointestinal tract.</p><p>Use of vaginal dinoprostone to induce labor appears to have a negative effect on breastfeeding. Given orally in the first few days postpartum, dinoprostone can suppress lactation. Whether postpartum vaginal or endocervical administration suppresses lactation is not known, but it should probably not be used postpartum in mothers who wish to breastfeed. By one month postpartum, the drug appears not to suppress lactation.</p></div><div id="LM738.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Milk levels of dinoprostone have not been measured after exogenous administration to humans. However, it is a normal component of breastmilk, where it may play a role in protecting the infant's gastrointestinal tract.[<a class="bibr" href="#LM738.REF.1" rid="LM738.REF.1">1</a>-<a class="bibr" href="#LM738.REF.7" rid="LM738.REF.7">7</a>] Normal concentrations in milk vary widely over a range up to about 500 ng/L, but appear to be similar to the maternal plasma concentrations.[<a class="bibr" href="#LM738.REF.5" rid="LM738.REF.5">5</a>]</p><p>Vaginal or endocervical administration of dinoprostone for induction of labor produces maternal serum concentrations about double the normal levels, so milk concentrations are likely to be comparably higher following exogenous administration.[<a class="bibr" href="#LM738.REF.8" rid="LM738.REF.8">8</a>,<a class="bibr" href="#LM738.REF.9" rid="LM738.REF.9">9</a>]</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM738.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM738.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>A retrospective cohort study of birth records in Cardiff, Wales, UK found that the use of vaginal prostaglandins for the induction of labor resulted in an 11% decrease in the likelihood that mothers would be breastfeeding at 48 hours postpartum. The subgroup of first-time mothers had a 15% decrease.[<a class="bibr" href="#LM738.REF.10" rid="LM738.REF.10">10</a>]</p><p>A nonrandomized prospective study compared women who had spontaneous deliveries with those who had elective induction using dinoprostone vaginal gel. At hospital discharge, exclusive breastfeeding rates were similar between the two groups (88% and 89%). However, at 1 and 3 months postpartum, exclusive breastfeeding rates were significantly lower in mothers who had dinoprostone induction than in those who delivered spontaneously. Exclusive breastfeeding rates were 54% and 85% at 1 month and 46% and 59% at 3 months postpartum, respectively. Rates of supplemental and exclusive formula feeding were higher in the induced mothers at both time points also.[<a class="bibr" href="#LM738.REF.11" rid="LM738.REF.11">11</a>]</p><p>Dinoprostone has been used investigationally to inhibit postpartum lactation and engorgement by reducing serum prolactin concentrations.[<a class="bibr" href="#LM738.REF.12" rid="LM738.REF.12">12</a>-<a class="bibr" href="#LM738.REF.16" rid="LM738.REF.16">16</a>] The effect on prolactin levels, engorgement and lactation appears to be dose and duration related. Oral dosages of 3 mg daily for 4 days or 0.5 mg three times daily were ineffective,[<a class="bibr" href="#LM738.REF.16" rid="LM738.REF.16">16</a>,<a class="bibr" href="#LM738.REF.17" rid="LM738.REF.17">17</a>] whereas oral dosages of 8 to 12 mg over 24 to 30 hours were effective.[<a class="bibr" href="#LM738.REF.12" rid="LM738.REF.12">12</a>,<a class="bibr" href="#LM738.REF.14" rid="LM738.REF.14">14</a>] These effects seem to be limited to the first few days postpartum; dinoprostone had no effect on serum prolactin or milk production when given to women 30 days postpartum.[<a class="bibr" href="#LM738.REF.12" rid="LM738.REF.12">12</a>] Compared to oral bromocriptine 2.5 mg every 12 hours for 14 days, dinoprostone 12 mg orally in divided doses over 30 hours was as effective as bromocriptine, but resulted in less rebound breast tenderness.[<a class="bibr" href="#LM738.REF.14" rid="LM738.REF.14">14</a>]</p></div><div id="LM738.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="LM738.REF.1">Lucas
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N, Stanczyk
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[<a href="https://pubmed.ncbi.nlm.nih.gov/11111068" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11111068</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>9.</dt><dd><div class="bk_ref" id="LM738.REF.9">Siqueira
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M, Neves
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[Plasma prostaglandin E2 in pregnant women undergoing labor induction with endocervical gel application]. Rev Esp Med Nucl
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S, Emery
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Associations of drugs routinely given in labour with breastfeeding at 48 hours: Analysis of the Cardiff births survey.
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BJOG
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[<a href="https://pubmed.ncbi.nlm.nih.gov/19735379" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19735379</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>11.</dt><dd><div class="bk_ref" id="LM738.REF.11">Zanardo
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The adaptive psychological changes of elective induction of labor in breastfeeding women.
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Suppression of lactation. A comparison of bromocriptine and prostaglandin E2.
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[Postpartum uterus involution and lactation levels in randomized comparison between prostin E2 tablets and methergine dragees]. Gynakol Rundsch
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[<a href="https://pubmed.ncbi.nlm.nih.gov/6347832" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 6347832</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>17.</dt><dd><div class="bk_ref" id="LM738.REF.17">Tulandi
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T, Gelfand
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LM. Effect of prostaglandin E2 on puerperal breast discomfort and prolactin secretion.
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J Reprod Med
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1985;30:176-8.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/3858547" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 3858547</span></a>]</div></dd></dl></dl></div></div><div id="LM738.Substance_Identification"><h2 id="_LM738_Substance_Identification_">Substance Identification</h2><div id="LM738.Substance_Name"><h3>Substance Name</h3><p>Dinoprostone</p></div><div id="LM738.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>363-24-6</p></div><div id="LM738.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Oxytocics</p><p>Prostaglandins</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK501637_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">November 15, 2024</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Dinoprostone. [Updated 2024 Nov 15].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/lactmed/dimethylsulfone/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/lactmed/LM1187/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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