132 lines
No EOL
18 KiB
XML
132 lines
No EOL
18 KiB
XML
<?xml version="1.0" encoding="utf-8"?>
|
|
<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd">
|
|
<html xmlns="http://www.w3.org/1999/xhtml" xml:lang="en" lang="en">
|
|
|
|
<head><meta http-equiv="Content-Type" content="text/html; charset=utf-8" />
|
|
<!-- AppResources meta begin -->
|
|
<meta name="paf-app-resources" content="" />
|
|
<script type="text/javascript">var ncbi_startTime = new Date();</script>
|
|
|
|
<!-- AppResources meta end -->
|
|
|
|
<!-- TemplateResources meta begin -->
|
|
<meta name="paf_template" content="" />
|
|
|
|
<!-- TemplateResources meta end -->
|
|
|
|
<!-- Logger begin -->
|
|
<meta name="ncbi_db" content="books" /><meta name="ncbi_pdid" content="book-part" /><meta name="ncbi_acc" content="NBK501633" /><meta name="ncbi_domain" content="lactmed" /><meta name="ncbi_report" content="printable" /><meta name="ncbi_type" content="fulltext" /><meta name="ncbi_objectid" content="" /><meta name="ncbi_pcid" content="/NBK501633/?report=printable" /><meta name="ncbi_app" content="bookshelf" />
|
|
<!-- Logger end -->
|
|
|
|
<title>Pyrethrins - Drugs and Lactation Database (LactMed®) - NCBI Bookshelf</title>
|
|
|
|
<!-- AppResources external_resources begin -->
|
|
<link rel="stylesheet" href="/core/jig/1.15.2/css/jig.min.css" /><script type="text/javascript" src="/core/jig/1.15.2/js/jig.min.js"></script>
|
|
|
|
<!-- AppResources external_resources end -->
|
|
|
|
<!-- Page meta begin -->
|
|
<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]" /><meta name="citation_title" content="Pyrethrins" /><meta name="citation_publisher" content="National Institute of Child Health and Human Development" /><meta name="citation_date" content="2023/09/15" /><meta name="citation_pmid" content="30000694" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK501633/" /><meta name="citation_keywords" content="Pyrethrins" /><meta name="citation_keywords" content="Firmotox" /><meta name="citation_keywords" content="Pyrenone" /><meta name="citation_keywords" content="Pyrethres" /><meta name="citation_keywords" content="Pyrocide" /><meta name="citation_keywords" content="Pyronyl" /><meta name="citation_keywords" content="Buhach" /><meta name="citation_keywords" content="Goldgeist forte" /><meta name="citation_keywords" content="Trieste flowers" /><meta name="citation_keywords" content="Biopiren plus" /><meta name="citation_keywords" content="Insect powder" /><meta name="citation_keywords" content="Pyrethrum extract" /><meta name="citation_keywords" content="Cinerin I or II" /><meta name="citation_keywords" content="Jasmolin I or II" /><meta name="citation_keywords" content="Pyrethrin I or II" /><meta name="citation_keywords" content="PYRETHRUM" /><meta name="citation_keywords" content="Persian insect powder" /><meta name="citation_keywords" content="Caswell No. 716" /><meta name="citation_keywords" content="Dalmatian insect powder" /><meta name="citation_keywords" content="Pyrethrum (insecticide)" /><meta name="citation_keywords" content="Dalmation insect flowers" /><meta name="citation_keywords" content="Insecticides, pyrethrins" /><meta name="citation_keywords" content="Pyrethrins [BSI:ISO]" /><meta name="citation_keywords" content="Prentox pyrethrum extract" /><meta name="citation_keywords" content="Pyrethres [ISO-French]" /><meta name="citation_keywords" content="Pyrethrum extract [USP]" /><meta name="citation_keywords" content="Pyrethrins and Pyrethroids" /><meta name="citation_keywords" content="UNII-ZUM06L90GV" /><meta name="citation_keywords" content="ZUM06L90GV" /><meta name="citation_keywords" content="HSDB 6297" /><meta name="citation_keywords" content="EINECS 232-319-8" /><meta name="citation_keywords" content="Pyrethrum powder other than pyrethrins" /><meta name="citation_keywords" content="EPA Pesticide Chemical Code 069002" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Pyrethrins" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Child Health and Human Development" /><meta name="DC.Date" content="2023/09/15" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK501633/" /><meta name="description" content="Because absorption after topical application is very limited, occasional pyrethrins and piperonyl butoxide use is acceptable in nursing mothers. Extensive exposure, such as from agricultural use or malaria control might have long-term health concerns because residues can be found in breastmilk.[1] Only water-miscible cream, gel or liquid products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.[2]" /><meta name="og:title" content="Pyrethrins" /><meta name="og:type" content="book" /><meta name="og:description" content="Because absorption after topical application is very limited, occasional pyrethrins and piperonyl butoxide use is acceptable in nursing mothers. Extensive exposure, such as from agricultural use or malaria control might have long-term health concerns because residues can be found in breastmilk.[1] Only water-miscible cream, gel or liquid products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.[2]" /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK501633/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-lactmed-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/lactmed/LM734/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK501633/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
|
|
|
|
<!-- Page meta end -->
|
|
<link rel="shortcut icon" href="//www.ncbi.nlm.nih.gov/favicon.ico" /><meta name="ncbi_phid" content="CE8EF49E7D8326010000000000D700B6.m_5" />
|
|
<meta name='referrer' content='origin-when-cross-origin'/><link type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4216699/css/3852956/3985586/3808861/4121862/3974050/3917732/251717/4216701/14534/45193/4113719/3849091/3984811/3751656/4033350/3840896/3577051/3852958/3984801/12930/3964959.css" /><link type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4216699/css/3411343/3882866.css" media="print" /></head>
|
|
<body class="book-part">
|
|
<div class="grid no_max_width">
|
|
<div class="col twelve_col nomargin shadow">
|
|
<!-- System messages like service outage or JS required; this is handled by the TemplateResources portlet -->
|
|
<div class="sysmessages">
|
|
<noscript>
|
|
<p class="nojs">
|
|
<strong>Warning:</strong>
|
|
The NCBI web site requires JavaScript to function.
|
|
<a href="/guide/browsers/#enablejs" title="Learn how to enable JavaScript" target="_blank">more...</a>
|
|
</p>
|
|
</noscript>
|
|
</div>
|
|
<!--/.sysmessage-->
|
|
<div class="wrap">
|
|
<div class="page">
|
|
<div class="top">
|
|
|
|
<div class="header">
|
|
|
|
|
|
</div>
|
|
|
|
|
|
|
|
<!--<component id="Page" label="headcontent"/>-->
|
|
|
|
</div>
|
|
<div class="content">
|
|
<!-- site messages -->
|
|
<div class="container content">
|
|
<div class="document">
|
|
<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
|
|
<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK501633_"><span class="title" itemprop="name">Pyrethrins</span></h1><p class="small">Last Revision: <span itemprop="dateModified">September 15, 2023</span>.</p><p><em>Estimated reading time: 1 minute</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 8003-34-7</p><div id="LM734.Drug_Levels_and_Effects"><h2 id="_LM734_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM734.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Because absorption after topical application is very limited, occasional pyrethrins and piperonyl butoxide use is acceptable in nursing mothers. Extensive exposure, such as from agricultural use or malaria control might have long-term health concerns because residues can be found in breastmilk.[<a class="bk_pop" href="#LM734.REF.1">1</a>] Only water-miscible cream, gel or liquid products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.[<a class="bk_pop" href="#LM734.REF.2">2</a>]</p></div><div id="LM734.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Pyrethrins were measured in 53 breastmilk samples from 29 mothers collected 1998 to 1999 in Basel Switzerland. Pyrethrins were detected in 42 milk samples, even in mothers from households that reported no pyrethrin use. The average pyrethrins concentration was 89 mcg/kg of fat (range undetectable [<25 mcg/kg] to 341 mcg/kg fat).[<a class="bk_pop" href="#LM734.REF.3">3</a>]</p><p>Pyrethroids (permethrin, cyfluthrin, cypermethrin and deltamethrin) were found in the breastmilk of nursing mothers in 3 South African towns. Average levels in breastmilk ranged from 8.3 to 48.4 mcg/L in the 3 towns. The source was thought to be from a dusting powder widely available and used in gardening. The dosage and route of exposure (i.e., topical, inhalation, oral) could not be determined. All milk levels were below the allowable daily limit for permethrin.[<a class="bk_pop" href="#LM734.REF.4">4</a>,<a class="bk_pop" href="#LM734.REF.5">5</a>]</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM734.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM734.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM734.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p><a href="/books/n/lactmed/LM499/">Ivermectin</a>, <a href="/books/n/lactmed/LM505/">Permethrin</a></p></div><div id="LM734.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="LM734.REF.1">Bouwman
|
|
H, Kylin
|
|
H. Malaria control insecticide residues in breast milk: the need to consider infant health risks.
|
|
Environ Health Perspect
|
|
2009;117:1477-80. [<a href="/pmc/articles/PMC2790498/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC2790498</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/20019894" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 20019894</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="LM734.REF.2">Noti
|
|
A, Grob
|
|
K, Biedermann
|
|
M, et al.
|
|
Exposure of babies to C(15)-C(45) mineral paraffins from human milk and breast salves.
|
|
Regul Toxicol Pharmacol
|
|
2003;38:317-25. [<a href="https://pubmed.ncbi.nlm.nih.gov/14623482" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 14623482</span></a>]</div></dd><dt>3.</dt><dd><div class="bk_ref" id="LM734.REF.3">Zehringer
|
|
M, Herrmann
|
|
A. Analysis of polychlorinated biphenyls, pyrethroid insecticides and fragrances in human milk using a laminar cup liner in the GC injector.
|
|
Eur Food Res Technol
|
|
2001;212:247-51. doi:10.1007/s002170000223 [<a href="http://dx.crossref.org/10.1007/s002170000223" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">CrossRef</a>]</div></dd><dt>4.</dt><dd><div class="bk_ref" id="LM734.REF.4">Sereda
|
|
B, Bouwman
|
|
H, Kylin
|
|
H. Comparing water, bovine milk, and indoor residual spraying as possible sources of DDT and pyrethroid residues in breast milk.
|
|
J Toxicol Environ Health A
|
|
2009;72:842-51. [<a href="https://pubmed.ncbi.nlm.nih.gov/19557612" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19557612</span></a>]</div></dd><dt>5.</dt><dd><div class="bk_ref" id="LM734.REF.5">Bouwman
|
|
H, Sereda
|
|
B, Meinhardt
|
|
HM. Simultaneous presence of DDT and pyrethroid residues in human breast milk from a malaria endemic area in South Africa.
|
|
Environ Pollut
|
|
2006;144:902-17. [<a href="https://pubmed.ncbi.nlm.nih.gov/16564119" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16564119</span></a>]</div></dd></dl></div></div><div id="LM734.Substance_Identification"><h2 id="_LM734_Substance_Identification_">Substance Identification</h2><div id="LM734.Substance_Name"><h3>Substance Name</h3><p>Pyrethrins</p></div><div id="LM734.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>8003-34-7</p></div><div id="LM734.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Anti-Infective Agents</p><p>Antiparasitic Agents</p><p>Insecticides</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
|
|
<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div><div class="small"><span class="label">Bookshelf ID: NBK501633</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/30000694" title="PubMed record of this page" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">30000694</a></span></div><div style="margin-top:2em" class="bk_noprnt"><a class="bk_cntns" href="/books/n/lactmed/">Contents</a><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/lactmed/LM472/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/lactmed/LM508/" title="Next page in this title">Next ></a></div></div></div></div>
|
|
|
|
</div>
|
|
</div>
|
|
</div>
|
|
<div class="bottom">
|
|
|
|
<div id="NCBIFooter_dynamic">
|
|
<!--<component id="Breadcrumbs" label="breadcrumbs"/>
|
|
<component id="Breadcrumbs" label="helpdesk"/>-->
|
|
|
|
</div>
|
|
|
|
<script type="text/javascript" src="/portal/portal3rc.fcgi/rlib/js/InstrumentNCBIBaseJS/InstrumentPageStarterJS.js"> </script>
|
|
</div>
|
|
</div>
|
|
<!--/.page-->
|
|
</div>
|
|
<!--/.wrap-->
|
|
</div><!-- /.twelve_col -->
|
|
</div>
|
|
<!-- /.grid -->
|
|
|
|
<span class="PAFAppResources"></span>
|
|
|
|
<!-- BESelector tab -->
|
|
|
|
|
|
|
|
<noscript><img alt="statistics" src="/stat?jsdisabled=true&ncbi_db=books&ncbi_pdid=book-part&ncbi_acc=NBK501633&ncbi_domain=lactmed&ncbi_report=printable&ncbi_type=fulltext&ncbi_objectid=&ncbi_pcid=/NBK501633/?report=printable&ncbi_app=bookshelf" /></noscript>
|
|
|
|
|
|
<!-- usually for JS scripts at page bottom -->
|
|
<!--<component id="PageFixtures" label="styles"></component>-->
|
|
|
|
|
|
<!-- CE8B5AF87C7FFCB1_0191SID /projects/books/PBooks@9.11 portal107 v4.1.r689238 Tue, Oct 22 2024 16:10:51 -->
|
|
<span id="portal-csrf-token" style="display:none" data-token="CE8B5AF87C7FFCB1_0191SID"></span>
|
|
|
|
<script type="text/javascript" src="//static.pubmed.gov/portal/portal3rc.fcgi/4216699/js/3879255/4121861/3501987/4008961/3893018/3821238/3400083/3426610.js" snapshot="books"></script></body>
|
|
</html> |