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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]" /><meta name="citation_title" content="Zoledronic Acid" /><meta name="citation_publisher" content="National Institute of Child Health and Human Development" /><meta name="citation_date" content="2018/12/03" /><meta name="citation_pmid" content="30000681" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK501620/" /><meta name="citation_keywords" content="Zoledronic acid" /><meta name="citation_keywords" content="Zoledronate" /><meta name="citation_keywords" content="Zometa" /><meta name="citation_keywords" content="Reclast" /><meta name="citation_keywords" content="Aclasta" /><meta name="citation_keywords" content="118072-93-8" /><meta name="citation_keywords" content="Orazol" /><meta name="citation_keywords" content="CGP 42446" /><meta name="citation_keywords" content="UNII-70HZ18PH24" /><meta name="citation_keywords" content="BPH 91" /><meta name="citation_keywords" content="ZOL 446" /><meta name="citation_keywords" content="70HZ18PH24" /><meta name="citation_keywords" content="Zoledronic acid [USAN:INN:BAN]" /><meta name="citation_keywords" content="(1-Hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid" /><meta name="citation_keywords" content="Phosphonic acid, (1-hydroxy-2-(1H-imidazol-1-yl)ethylidene)bis-" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Zoledronic Acid" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Child Health and Human Development" /><meta name="DC.Date" content="2018/12/03" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK501620/" /><meta name="description" content="Because no information is available on the use of zoledronic acid during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. However, absorption of zoledronic acid by a breastfed infant is unlikely." /><meta name="og:title" content="Zoledronic Acid" /><meta name="og:type" content="book" /><meta name="og:description" content="Because no information is available on the use of zoledronic acid during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. However, absorption of zoledronic acid by a breastfed infant is unlikely." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK501620/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-lactmed-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/lactmed/LM722/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK501620/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK501620_"><span class="title" itemprop="name">Zoledronic Acid</span></h1><p class="small">Last Revision: <span itemprop="dateModified">December 3, 2018</span>.</p><p><em>Estimated reading time: 1 minute</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 118072-93-8</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/135026283" title="Structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="/books/NBK501620/bin/S135026283v6.jpg" alt="Chemical structure" /></a><div id="LM722.drug-levels-effects"><h2 id="_LM722_drug-levels-effects_">Drug Levels and Effects</h2><div id="LM722.sum-use"><h3>Summary of Use during Lactation</h3><p>Because no information is available on the use of zoledronic acid during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. However, absorption of zoledronic acid by a breastfed infant is unlikely.</p></div><div id="LM722.drug-levels"><h3>Drug Levels</h3><p>Zoledronic acid has a serum half-life of about 1.7 hours and is poorly absorbed orally, so absorption of zoledronic acid by a breastfed infant is unlikely.</p><p><i>Maternal Levels.</i> Relevant published information was not found as of the revision date.</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM722.effects-inf"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM722.effects-lact"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM722.alt-drug"><h3>Alternate Drugs to Consider</h3><p>
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<a href="/books/n/lactmed/LM502/">Pamidronate</a>
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</p></div></div><div id="LM722.subst-id"><h2 id="_LM722_subst-id_">Substance Identification</h2><div id="LM722.subst-name"><h3>Substance Name</h3><p>Zoledronic Acid</p></div><div id="LM722.casno"><h3>CAS Registry Number</h3><p>118072-93-8</p></div><div id="LM722.drug-class"><h3>Drug Class</h3><ul class="simple-list"><li class="half_rhythm"><div>Breast Feeding</div></li><li class="half_rhythm"><div>Lactation</div></li><li class="half_rhythm"><div>Bisphosphonates</div></li><li class="half_rhythm"><div>Bone Density Conservation Agents</div></li><li class="half_rhythm"><div>Diphosphonates</div></li></ul></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div><div class="small"><span class="label">Bookshelf ID: NBK501620</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/30000681" title="PubMed record of this page" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">30000681</a></span></div><div style="margin-top:2em" class="bk_noprnt"><a class="bk_cntns" href="/books/n/lactmed/">Contents</a><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/lactmed/zolbetuximab/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/lactmed/LM579/" title="Next page in this title">Next ></a></div></div></div></div>
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