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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]" /><meta name="citation_title" content="Coal Tar" /><meta name="citation_publisher" content="National Institute of Child Health and Human Development" /><meta name="citation_date" content="2024/10/15" /><meta name="citation_pmid" content="30000676" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK501615/" /><meta name="citation_keywords" content="Impervotar" /><meta name="citation_keywords" content="Pixalbol" /><meta name="citation_keywords" content="Fototar" /><meta name="citation_keywords" content="Lavatar" /><meta name="citation_keywords" content="Zetar" /><meta name="citation_keywords" content="Picis carbonis" /><meta name="citation_keywords" content="AquaTar" /><meta name="citation_keywords" content="Polytar bath" /><meta name="citation_keywords" content="Carbo-cort" /><meta name="citation_keywords" content="Coking tar" /><meta name="citation_keywords" content="Coke-oven tar" /><meta name="citation_keywords" content="Tar, coking" /><meta name="citation_keywords" content="Vanseb-T" /><meta name="citation_keywords" content="Ionil-T" /><meta name="citation_keywords" content="Ionil-T-Plus" /><meta name="citation_keywords" content="Tar, coal" /><meta name="citation_keywords" content="Tarcron 180" /><meta name="citation_keywords" content="Tarcron 180L" /><meta name="citation_keywords" content="Tarcron 230" /><meta name="citation_keywords" content="Caswell No. 223" /><meta name="citation_keywords" content="RT 7" /><meta name="citation_keywords" content="Estar (skin treatment)" /><meta name="citation_keywords" content="R533ESO2EC" /><meta name="citation_keywords" content="R533ESO2EC" /><meta name="citation_keywords" content="8631" /><meta name="citation_keywords" content="RT 7" /><meta name="citation_keywords" content="HSDB 5050" /><meta name="citation_keywords" content="EINECS 232-361-7" /><meta name="citation_keywords" content="KC 261" /><meta name="citation_keywords" content="EPA Pesticide Chemical Code 022003" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Coal Tar" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Child Health and Human Development" /><meta name="DC.Date" content="2024/10/15" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK501615/" /><meta name="description" content="Coal tar applied topically to maternal skin can result in pyrene absorption by the infant, probably by skin-to-skin or skin-to-mouth contact with the mother. Because of the potential toxicity of coal tar to the breastfed infant, alternate drugs are preferred.[1] If a coal tar product is used, it would be prudent to treat the smallest area of skin possible. It is particularly important to ensure that the infant's skin does not come into direct contact with the areas of skin that have been treated." /><meta name="og:title" content="Coal Tar" /><meta name="og:type" content="book" /><meta name="og:description" content="Coal tar applied topically to maternal skin can result in pyrene absorption by the infant, probably by skin-to-skin or skin-to-mouth contact with the mother. Because of the potential toxicity of coal tar to the breastfed infant, alternate drugs are preferred.[1] If a coal tar product is used, it would be prudent to treat the smallest area of skin possible. It is particularly important to ensure that the infant's skin does not come into direct contact with the areas of skin that have been treated." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK501615/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-lactmed-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/lactmed/LM718/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK501615/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK501615_"><span class="title" itemprop="name">Coal Tar</span></h1><p class="small">Last Revision: <span itemprop="dateModified">October 15, 2024</span>.</p><p><em>Estimated reading time: 2 minutes</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 8007-45-2</p><div id="LM718.Drug_Levels_and_Effects"><h2 id="_LM718_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM718.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Coal tar applied topically to maternal skin can result in pyrene absorption by the infant, probably by skin-to-skin or skin-to-mouth contact with the mother. Because of the potential toxicity of coal tar to the breastfed infant, alternate drugs are preferred.[<a class="bk_pop" href="#LM718.REF.1">1</a>] If a coal tar product is used, it would be prudent to treat the smallest area of skin possible. It is particularly important to ensure that the infant's skin does not come into direct contact with the areas of skin that have been treated.</p></div><div id="LM718.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels</i>. A woman was treated with topical coal tar-containing medications for the treatment of atopic dermatitis. They were applied to the entire body except for the breasts and face. Treatment was started when the infant was 3 months old and continued for 50 days. Breastmilk was analyzed before treatment and on 11 occasions during therapy. Pyrene and benzo[a]pyrene were undetectable (<0.0035 and 0.056 micromol/L, respectively). The pyrene metabolite, 1-hydroxypyrene, was detected in trace amounts in 3 of the 11 samples.[<a class="bk_pop" href="#LM718.REF.2">2</a>]</p><p><i>Infant Levels.</i> A woman was treated with topical coal tar-containing medications for the treatment of atopic dermatitis. They were applied to the entire body except for the breasts and face. Treatment was started when the infant was 3 months old and continued for 50 days. The mother breastfed her infant (extent not stated) and the infant's urine was collected before the start of treatment and 4 times during maternal therapy with coal tar. The pyrene metabolite, 1-hydroxypyrene, was detected in all of the infant's urine samples. The baseline (pretreatment) concentration was 1.63 micromol/mol of creatinine. Subsequent (during maternal treatment) urine concentrations were 9.96, 97.1, 8.67 and 11.3 micromol/mol of creatinine. Since the mother's breastmilk contained no detectable pyrene or benzo[a]pyrene and only low levels of 1-hydroxypyrene, the authors postulated that the infant obtained the pyrene via skin-to-skin or skin-to-mouth contact with the mother and metabolized it to 1-hydroxypyrene.[<a class="bk_pop" href="#LM718.REF.2">2</a>]</p></div><div id="LM718.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM718.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM718.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p>(Psoriasis) <a href="/books/n/lactmed/LM513/">Adalimumab</a>, <a href="/books/n/lactmed/LM752/">Certolizumab Pegol</a>, <a href="/books/n/lactmed/LM105/">Etanercept</a>, <a href="/books/n/lactmed/LM476/">Infliximab</a>, <a href="/books/n/lactmed/LM1293/">Phototherapy</a>, <a href="/books/n/lactmed/LM539/">Tretinoin</a></p></div><div id="LM718.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="LM718.REF.1">Yaghi
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M, McMullan
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P, Truong
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TM, et al.
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Safety of dermatologic medications in pregnancy and lactation: An Update - Part II: Lactation.
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J Am Acad Dermatol
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2024;91:651-68.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/38280680" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 38280680</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="LM718.REF.2">Scheepers
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PT, van Houtum
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JL, Anzion
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RB, et al.
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Uptake of pyrene in a breast-fed child of a mother treated with coal tar.
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Pediatr Dermatol
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2009;26:184-7.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/19419468" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19419468</span></a>]</div></dd></dl></div></div><div id="LM718.Substance_Identification"><h2 id="_LM718_Substance_Identification_">Substance Identification</h2><div id="LM718.Substance_Name"><h3>Substance Name</h3><p>Coal Tar</p></div><div id="LM718.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>8007-45-2</p></div><div id="LM718.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Keratolytic Agents</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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