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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Dapsone - Drugs and Lactation Database (LactMed®) - NCBI Bookshelf</title>
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<meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]">
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<meta name="citation_title" content="Dapsone">
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<meta name="citation_publisher" content="National Institute of Child Health and Human Development">
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<meta name="citation_date" content="2024/09/15">
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<meta name="citation_pmid" content="30000649">
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<meta name="citation_keywords" content="dapsone">
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<meta name="citation_keywords" content="Diaphenylsulfone">
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<meta name="citation_keywords" content="Dapson">
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<meta name="citation_keywords" content="Diaphenylsulfon">
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<meta name="citation_keywords" content="Sulfona">
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<meta name="citation_keywords" content="Avlosulfone">
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<meta name="citation_keywords" content="Diphenasone">
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<meta name="citation_keywords" content="Sulfadione">
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<meta name="citation_keywords" content="Sulphadione">
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<meta name="citation_keywords" content="Disulone">
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<meta name="citation_keywords" content="Udolac">
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<meta name="citation_keywords" content="Croysulfone">
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<meta name="citation_keywords" content="Avlosulfon">
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<meta name="citation_keywords" content="Novophone">
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<meta name="citation_keywords" content="Dapsonum">
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<meta name="citation_keywords" content="Dumitone">
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<meta name="citation_keywords" content="Diphone">
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<meta name="citation_keywords" content="Eporal">
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<meta name="citation_keywords" content="Diaphenylsulphon">
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<meta name="citation_keywords" content="Avlosulphone">
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<meta name="citation_keywords" content="Croysulphone">
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<meta name="citation_keywords" content="Dubronax">
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<meta name="citation_keywords" content="Diaphenylsulphone">
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<meta name="citation_keywords" content="Tarimyl">
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<meta name="citation_keywords" content="Metabolite C">
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<meta name="citation_keywords" content="Aczone">
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<meta name="citation_keywords" content="Sumicure S">
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<meta name="citation_keywords" content="Sulfone ucb">
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<meta name="citation_keywords" content="DADPS">
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<meta name="citation_keywords" content="Dapsona">
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<meta name="citation_keywords" content="Sulfona-MAE">
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<meta name="citation_keywords" content="Araldite HT 976">
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<meta name="citation_keywords" content="Hardener HT 976">
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<meta name="citation_keywords" content="CCRIS 192">
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<meta name="citation_keywords" content="NCI-C01718">
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<meta name="citation_keywords" content="WR 448">
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<meta name="citation_keywords" content="4,4-Diaminodifenylsulfon [Czech]">
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<meta name="citation_keywords" content="HSDB 5073">
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<meta name="citation_keywords" content="UNII-8W5C518302">
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<meta name="citation_keywords" content="EINECS 201-248-4">
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<meta name="citation_keywords" content="1358F">
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<meta name="citation_keywords" content="F 1358">
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<meta name="citation_keywords" content="BRN 0788055">
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<meta name="citation_keywords" content="AI3-08087">
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<meta name="citation_keywords" content="DDS">
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<meta name="citation_keywords" content="8W5C518302">
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<meta name="citation_keywords" content="EC 201-248-4">
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<meta name="citation_keywords" content="4-13-00-01306 (Beilstein Handbook Reference)">
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<meta name="citation_keywords" content="4-(4-aminophenyl)sulfonylaniline">
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<link rel="schema.DC" href="http://purl.org/DC/elements/1.0/">
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<meta name="DC.Title" content="Dapsone">
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<meta name="DC.Publisher" content="National Institute of Child Health and Human Development">
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<meta name="DC.Date" content="2024/09/15">
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<meta name="description" content="Dapsone can be used during breastfeeding; however, hemolytic anemia might occur, especially in newborn infants and in those with glucose-6-phosphate dehydrogenase (G6PD) deficiency. The time of greatest risk for hemolysis in fullterm newborns without G6PD deficiency might be as short as 8 days after birth.[1] One source states that use of dapsone in the treatment of leprosy is advantageous because it kills the organisms in breastmilk.[2] Monitor the infant for signs of hemolysis, especially in newborn or premature breastfed infants.">
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<meta name="og:description" content="Dapsone can be used during breastfeeding; however, hemolytic anemia might occur, especially in newborn infants and in those with glucose-6-phosphate dehydrogenase (G6PD) deficiency. The time of greatest risk for hemolysis in fullterm newborns without G6PD deficiency might be as short as 8 days after birth.[1] One source states that use of dapsone in the treatment of leprosy is advantageous because it kills the organisms in breastmilk.[2] Monitor the infant for signs of hemolysis, especially in newborn or premature breastfed infants.">
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class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK501589_"><span class="title" itemprop="name">Dapsone</span></h1><p class="fm-aai"><a href="#_NBK501589_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 2 minutes</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><p>CASRN: 80-08-0</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134971843" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134971843" alt="image 134971843 in the ncbi pubchem database" /></a><div id="LM695.Drug_Levels_and_Effects"><h2 id="_LM695_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM695.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Dapsone can be used during breastfeeding; however, hemolytic anemia might occur, especially in newborn infants and in those with glucose-6-phosphate dehydrogenase (G6PD) deficiency. The time of greatest risk for hemolysis in fullterm newborns without G6PD deficiency might be as short as 8 days after birth.[<a class="bibr" href="#LM695.REF.1" rid="LM695.REF.1">1</a>] One source states that use of dapsone in the treatment of leprosy is advantageous because it kills the organisms in breastmilk.[<a class="bibr" href="#LM695.REF.2" rid="LM695.REF.2">2</a>] Monitor the infant for signs of hemolysis, especially in newborn or premature breastfed infants.</p><p>Topical dapsone gel used to treat acne has not been studied during breastfeeding. According to the manufacturer, topical dapsone gel results in a blood level of 1% that of a 100 mg oral dose. It is unlikely that the topical gel would affect the breastfed infant, but the manufacturer states that it should not be used during nursing. Until more data are available, an alternative topical agent might be preferred.</p></div><div id="LM695.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> In one mother who was 41 days postpartum, a random milk level of dapsone was about 1.1 mg/L with a maternal dose of 50 mg daily. Monoacetyldapsone was not detectable in milk although the maternal serum level was 744 mcg/L.[<a class="bibr" href="#LM695.REF.3" rid="LM695.REF.3">3</a>]</p><p>Three women who were 2 to 5 days postpartum were given a single dose of 100 mg of dapsone orally. Milk samples were obtained at various times up to about 220 hours after the dose. The authors calculated that the breastfed infants would receive an average of 9.6% (range 4.6 to 14.3%) of the maternal weight-adjusted dosage.[<a class="bibr" href="#LM695.REF.4" rid="LM695.REF.4">4</a>]</p><p><i>Infant Levels.</i> A mother who was 41 days postpartum was taking dapsone 50 mg daily. Her breastfed infant's serum had levels of 439 mcg/L of dapsone and 204 mcg/L of monoacetyldapsone.[<a class="bibr" href="#LM695.REF.3" rid="LM695.REF.3">3</a>]</p></div><div id="LM695.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>A case of mild hemolytic anemia occurred in a 41-day-old breastfed infant whose mother was taking dapsone 50 mg daily. The hemolysis was probably caused by dapsone in milk.[<a class="bibr" href="#LM695.REF.3" rid="LM695.REF.3">3</a>]</p><p>A woman with leprosy took dapsone, clofazimine and rifampin during pregnancy and breastfeeding. Her infant developed skin discoloration attributed to clofazimine which reversed 3 months after cessation of breastfeeding.[<a class="bibr" href="#LM695.REF.5" rid="LM695.REF.5">5</a>]</p></div><div id="LM695.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM695.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p>(Leprosy) <a href="/books/n/lactmed/LM430/?report=reader">Clofazimine</a>; (Topical for Acne) <a href="/books/n/lactmed/LM542/?report=reader">Adapalene</a>; <a href="/books/n/lactmed/LM541/?report=reader">Azelaic Acid</a>; <a href="/books/n/lactmed/LM540/?report=reader">Benzoyl Peroxide</a>; <a href="/books/n/lactmed/LM343/?report=reader">Clindamycin</a>; <a href="/books/n/lactmed/LM351/?report=reader">Erythromycin</a>; <a href="/books/n/lactmed/LM539/?report=reader">Tretinoin</a></p></div><div id="LM695.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="LM695.REF.1">Zao
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J, Koren
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G, Bozzo
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P. Using nitrofurantoin while breastfeeding a newborn.
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Can Fam Physician
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2014;60:539-40.
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[<a href="/pmc/articles/PMC4055319/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4055319</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/24925943" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24925943</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="LM695.REF.2">Jopling WH. Handbook of leprosy, 3rd ed. London: Heinemann Medical Books Ltd.; 1984</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="LM695.REF.3">Sanders
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SW, Zone
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JJ, Foltz
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RL, et al.
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Hemolytic anemia induced by dapsone transmitted through breast milk.
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Ann Intern Med
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1982;96:465-6.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/7065565" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 7065565</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>4.</dt><dd><div class="bk_ref" id="LM695.REF.4">Edstein
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MD, Veenendaal
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JR, Newman
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K, et al.
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Excretion of chloroquine, dapsone and pyrimethamine in human milk.
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Br J Clin Pharmacol
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1986;22:733-5.
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[<a href="/pmc/articles/PMC1401222/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC1401222</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/3567020" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 3567020</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>5.</dt><dd><div class="bk_ref" id="LM695.REF.5">Ozturk
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Z, Tatliparmak
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A. Leprosy treatment during pregnancy and breastfeeding: A case report and brief review of literature.
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Dermatol Ther
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2017;30:e12414.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/27549245" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27549245</span></a>]</div></dd></dl></dl></div></div><div id="LM695.Substance_Identification"><h2 id="_LM695_Substance_Identification_">Substance Identification</h2><div id="LM695.Substance_Name"><h3>Substance Name</h3><p>Dapsone</p></div><div id="LM695.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>80-08-0</p></div><div id="LM695.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Anti-Infective Agents</p><p>Leprostatic Agents</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK501589_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">September 15, 2024</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Dapsone. [Updated 2024 Sep 15].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/lactmed/daprodustat/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/lactmed/LM708/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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