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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Iobenguane I 123 - Drugs and Lactation Database (LactMed®) - NCBI Bookshelf</title>
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<meta name="citation_title" content="Iobenguane I 123">
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<meta name="citation_keywords" content="m-Iodobenzylguanidine-123I">
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<meta name="citation_keywords" content="123I-MIBG">
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<meta name="og:description" content="Information in this record refers to the use of iobenguane I 123 (I 123 meta-iodobenzylguanidine; I 123 MIBG) as a diagnostic agent. The manufacturer recommends that mothers should pump and discard milk for at least 6 days based on the physical half-life of I 123. However, other sources recommend shorter times, depending on the dose (see table). If breastfeeding is discontinued and the mother has expressed and saved milk prior to the examination, she can feed it to the infant during the period of nursing interruption.[1-3] The milk that is pumped by the mother during the time of breastfeeding interruption can either be discarded or stored refrigerated and given to the infant after 10 physical half-lives, or about 5.5 days, have elapsed.">
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class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK501560_"><span class="title" itemprop="name">Iobenguane I 123</span></h1><p class="fm-aai"><a href="#_NBK501560_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 1 minute</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><p>CASRN: 76924-93-1</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/135089558" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=135089558" alt="image 135089558 in the ncbi pubchem database" /></a><div id="LM668.Drug_Levels_and_Effects"><h2 id="_LM668_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM668.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Information in this record refers to the use of iobenguane I 123 (I 123 meta-iodobenzylguanidine; I 123 MIBG) as a diagnostic agent. The manufacturer recommends that mothers should pump and discard milk for at least 6 days based on the physical half-life of I 123. However, other sources recommend shorter times, depending on the dose (see table). If breastfeeding is discontinued and the mother has expressed and saved milk prior to the examination, she can feed it to the infant during the period of nursing interruption.[<a class="bibr" href="#LM668.REF.1" rid="LM668.REF.1">1</a>-<a class="bibr" href="#LM668.REF.3" rid="LM668.REF.3">3</a>] The milk that is pumped by the mother during the time of breastfeeding interruption can either be discarded or stored refrigerated and given to the infant after 10 physical half-lives, or about 5.5 days, have elapsed.</p><p>Mothers concerned about the level of radioactivity in their milk could ask to have it tested at a nuclear medicine facility at their hospital. When the radioactivity is at a safe level, she may resume breastfeeding. A method for measuring milk radioactivity and determining the time when a mother can safely resume breastfeeding has been published.[<a class="bibr" href="#LM668.REF.4" rid="LM668.REF.4">4</a>]</p><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figLM668Tc"><a href="/books/NBK501560/table/LM668.Tc/?report=objectonly" target="object" title="Table" class="img_link icnblk_img" rid-ob="figobLM668Tc"><img class="small-thumb" src="/corehtml/pmc/css/bookshelf/2.26/img/table-icon.gif" alt="Table Icon" /></a><div class="icnblk_cntnt"><h4 id="LM668.Tc"><a href="/books/NBK501560/table/LM668.Tc/?report=objectonly" target="object" rid-ob="figobLM668Tc">Table</a></h4></div></div></div><div id="LM668.Drug_Levels"><h3>Drug Levels</h3><p>I 123 is a gamma emitter with a photon energy of 159 keV and a physical half-life of 13.1 hours.[<a class="bibr" href="#LM668.REF.6" rid="LM668.REF.6">6</a>] The maximum effective half-life of I 123 MIBG is 8.56 hours.[<a class="bibr" href="#LM668.REF.3" rid="LM668.REF.3">3</a>]</p></div><div id="LM668.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM668.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM668.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="LM668.REF.1">Mountford
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P, Coakley
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A.
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A review of the secretion of radioactivity in human breast milk: Data, quantitative analysis and recommendations.
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Nucl Med Commun
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1989;10:15-27.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/2645546" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 2645546</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="LM668.REF.2">Early P, Sodee D. Principles and practice of nuclear medicine. 2nd ed. St Louis Mosby-Year Book, Inc 1995:1380-1.</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="LM668.REF.3">ARSAC notes for guidance: Good clinical practice in nuclear medicine. Notes for guidance on the clinical administration of radiopharmaceuticals and use of sealed radioactive sources. 2020. <a href="https://www.gov.uk/government/publications/arsac-notes-for-guidance" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">https://www<wbr style="display:inline-block"></wbr>​.gov.uk/government<wbr style="display:inline-block"></wbr>​/publications<wbr style="display:inline-block"></wbr>​/arsac-notes-for-guidance</a> [<a href="https://pubmed.ncbi.nlm.nih.gov/10732169" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 10732169</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>4.</dt><dd><div class="bk_ref" id="LM668.REF.4">Stabin
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M, Breitz
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H. Breast milk excretion of radiopharmaceuticals: Mechanisms, findings, and radiation dosimetry.
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J Nucl Med
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2000;41:863-73.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/10809203" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 10809203</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>5.</dt><dd><div class="bk_ref" id="LM668.REF.5">Stabin M. Doses from medical radiation sources. <a href="https://hps.org/hpspublications/articles/dosesfrommedicalradiation.html" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">https://hps<wbr style="display:inline-block"></wbr>​.org/hpspublications<wbr style="display:inline-block"></wbr>​/articles<wbr style="display:inline-block"></wbr>​/dosesfrommedicalradiation.html</a>. Accessed Nov 6, 2024.</div></dd></dl><dl class="bkr_refwrap"><dt>6.</dt><dd><div class="bk_ref" id="LM668.REF.6">Dilsizian V, Metter D, Palestro C, et al. Advisory Committee on Medical Uses of Isotopes (ACMUI) Sub-Committee on Nursing Mother Guidelines for the Medical Administration of Radioactive Material. Final report submitted: January 31, 2019. 2019. <a href="https://www.nrc.gov/docs/ML1903/ML19038A498.pdf" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">https://www<wbr style="display:inline-block"></wbr>​.nrc.gov/docs<wbr style="display:inline-block"></wbr>​/ML1903/ML19038A498.pdf</a></div></dd></dl></dl></div></div><div id="LM668.Substance_Identification"><h2 id="_LM668_Substance_Identification_">Substance Identification</h2><div id="LM668.Substance_Name"><h3>Substance Name</h3><p>Iobenguane I 123</p></div><div id="LM668.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>76924-93-1</p></div><div id="LM668.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Radiopharmaceuticals</p><p>Iodine Radioisotopes</p><p>Diagnostic Agents</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK501560_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">November 15, 2024</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Iobenguane I 123. [Updated 2024 Nov 15].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/lactmed/LM1335/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/lactmed/LM805/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article><article data-type="table-wrap" id="figobLM668Tc"><div id="LM668.Tc" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK501560/table/LM668.Tc/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__LM668.Tc_lrgtbl__"><table><thead><tr><th id="hd_h_LM668.Tc_1_1_1_1" scope="col" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Dose</th><th id="hd_h_LM668.Tc_1_1_1_2" scope="col" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Duration of Interruption</th></tr></thead><tbody><tr><td headers="hd_h_LM668.Tc_1_1_1_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">370 MBq (10 mCi)</td><td headers="hd_h_LM668.Tc_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">48 hours[<a class="bibr" href="#LM668.REF.5" rid="LM668.REF.5">5</a>]</td></tr><tr><td headers="hd_h_LM668.Tc_1_1_1_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11 MBq (0.3 mCi)</td><td headers="hd_h_LM668.Tc_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">None[<a class="bibr" href="#LM668.REF.6" rid="LM668.REF.6">6</a>]</td></tr></tbody></table></div></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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