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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]" /><meta name="citation_title" content="Guanfacine" /><meta name="citation_publisher" content="National Institute of Child Health and Human Development" /><meta name="citation_date" content="2024/11/15" /><meta name="citation_pmid" content="30000582" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK501522/" /><meta name="citation_keywords" content="Guanfacine" /><meta name="citation_keywords" content="Intuniv" /><meta name="citation_keywords" content="Guanfacina" /><meta name="citation_keywords" content="Guanfacinum" /><meta name="citation_keywords" content="UNII-30OMY4G3MK" /><meta name="citation_keywords" content="30OMY4G3MK" /><meta name="citation_keywords" content="EINECS 249-442-8" /><meta name="citation_keywords" content="N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Guanfacine" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Child Health and Human Development" /><meta name="DC.Date" content="2024/11/15" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK501522/" /><meta name="description" content="Because no information is available on the use of guanfacine during breastfeeding and its possible negative effects on lactation, other agents may be preferred, especially while nursing a newborn or preterm infant." /><meta name="og:title" content="Guanfacine" /><meta name="og:type" content="book" /><meta name="og:description" content="Because no information is available on the use of guanfacine during breastfeeding and its possible negative effects on lactation, other agents may be preferred, especially while nursing a newborn or preterm infant." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK501522/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-lactmed-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/lactmed/LM631/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK501522/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK501522_"><span class="title" itemprop="name">Guanfacine</span></h1><p class="small">Last Revision: <span itemprop="dateModified">November 15, 2024</span>.</p><p><em>Estimated reading time: 1 minute</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 29110-47-2</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134996308" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134996308" alt="image 134996308 in the ncbi pubchem database" /></a><div id="LM631.Drug_Levels_and_Effects"><h2 id="_LM631_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM631.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Because no information is available on the use of guanfacine during breastfeeding and its possible negative effects on lactation, other agents may be preferred, especially while nursing a newborn or preterm infant.</p></div><div id="LM631.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Relevant published information was not found as of the revision date.</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM631.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM631.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Published information on the effects of guanfacine on serum prolactin or on lactation in nursing mothers was not found as of the revision date. Guanfacine decreases basal serum prolactin in men and nonnursing women. Serum prolactin continues to decrease for at least 7 years during continuous use.[<a class="bk_pop" href="#LM631.REF.1">1</a>] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.</p></div><div id="LM631.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p>(ADHD) <a href="/books/n/lactmed/LM433/">Amphetamine</a>, <a href="/books/n/lactmed/LM833/">Dextroamphetamine</a>, <a href="/books/n/lactmed/LM834/">Lisdexamfetamine</a>, <a href="/books/n/lactmed/LM436/">Methylphenidate</a> (Hypertension) <a href="/books/n/lactmed/LM727/">Candesartan</a>, <a href="/books/n/lactmed/LM38/">Captopril</a>, <a href="/books/n/lactmed/LM26/">Benazepril</a>, <a href="/books/n/lactmed/LM102/">Enalapril</a>, <a href="/books/n/lactmed/LM160/">Lisinopril</a>, <a href="/books/n/lactmed/LM234/">Quinapril</a>, <a href="/books/n/lactmed/LM137/">Hydrochlorothiazide</a>, <a href="/books/n/lactmed/LM179/">Methyldopa</a>, <a href="/books/n/lactmed/LM301/">Propranolol</a></p></div><div id="LM631.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="LM631.REF.1">Hauger-Klevene
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JH, Balossi
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EC, Scornavacchi
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JC. Effects of guanfacine on growth hormone, prolactin, renin, lipoproteins and glucose in essential hypertension.
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Am J Cardiol
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1986;57:27E-31E.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/3513527" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 3513527</span></a>]</div></dd></dl></div></div><div id="LM631.Substance_Identification"><h2 id="_LM631_Substance_Identification_">Substance Identification</h2><div id="LM631.Substance_Name"><h3>Substance Name</h3><p>Guanfacine</p></div><div id="LM631.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>29110-47-2</p></div><div id="LM631.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Antihypertensive Agents</p><p>Adrenergic alpha-2 Receptor Agonists</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div><div class="small"><span class="label">Bookshelf ID: NBK501522</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/30000582" title="PubMed record of this page" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">30000582</a></span></div><div style="margin-top:2em" class="bk_noprnt"><a class="bk_cntns" href="/books/n/lactmed/">Contents</a><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/lactmed/LM623/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/lactmed/LM1327/" title="Next page in this title">Next ></a></div></div></div></div>
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