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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK501511_"><span class="title" itemprop="name">Cisapride</span></h1><p class="small">Last Revision: <span itemprop="dateModified">October 31, 2018</span>.</p><p><em>Estimated reading time: 1 minute</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 81098-60-4</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/135014802" title="Structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="/books/NBK501511/bin/S135014802v4.jpg" alt="Chemical structure" /></a><div id="LM621.drug-levels-effects"><h2 id="_LM621_drug-levels-effects_">Drug Levels and Effects</h2><div id="LM621.sum-use"><h3>Summary of Use during Lactation</h3><p>Cisapride was removed from the market in the United States by the U.S. Food and Drug Administration because of cardiac toxicity. Because of the low levels of cisapride in breastmilk, its use is acceptable in nursing mothers if it is required.</p></div><div id="LM621.drug-levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Ten women who averaged 1.2 days postpartum were given cisapride 20 mg orally every 8 hours for 4 days. Cisapride milk samples obtained before and 1 hour after the midday dose on day 4 were 4.8 mcg/L and 6.2 mcg/L, respectively.[1] The peak concentration corresponds to a maximum dose of 0.93 mcg/kg daily which is less that the 0.6 to 0.8 mg/kg daily infant dosage and about 0.1% of the maternal weight-adjusted dosage.</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM621.effects-inf"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM621.effects-lact"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM621.alt-drug"><h3>Alternate Drugs to Consider</h3><p>
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<a href="/books/n/lactmed/LM477/">Metoclopramide</a>
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</p></div><div id="LM621.refs"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="LM621.ref1">Hofmeyr GJ, Sonnendecker EWW. Secretion of the gastrokinetic agent cisapride in human milk. Eur J Clin Pharmacol. 1986;30:735-6. [<a href="https://pubmed.ncbi.nlm.nih.gov/3770067" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 3770067</span></a>]</div></dd></dl></div></div><div id="LM621.subst-id"><h2 id="_LM621_subst-id_">Substance Identification</h2><div id="LM621.subst-name"><h3>Substance Name</h3><p>Cisapride</p></div><div id="LM621.casno"><h3>CAS Registry Number</h3><p>81098-60-4</p></div><div id="LM621.drug-class"><h3>Drug Class</h3><ul class="simple-list"><li class="half_rhythm"><div>Breast Feeding</div></li><li class="half_rhythm"><div>Lactation</div></li><li class="half_rhythm"><div>Gastrointestinal Agents</div></li><li class="half_rhythm"><div>Serotonin Agonists</div></li></ul></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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