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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]" /><meta name="citation_title" content="Glycopyrrolate" /><meta name="citation_publisher" content="National Institute of Child Health and Human Development" /><meta name="citation_date" content="2022/11/30" /><meta name="citation_pmid" content="30000540" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK501480/" /><meta name="citation_keywords" content="GLYCOPYRROLATE" /><meta name="citation_keywords" content="glycopyrronium bromide" /><meta name="citation_keywords" content="Robinul" /><meta name="citation_keywords" content="Gastrodyn" /><meta name="citation_keywords" content="Glycopyrrolate bromide" /><meta name="citation_keywords" content="Nodapton" /><meta name="citation_keywords" content="Asecryl" /><meta name="citation_keywords" content="Tarodyl" /><meta name="citation_keywords" content="Tarodyn" /><meta name="citation_keywords" content="Copyrrolate" /><meta name="citation_keywords" content="Cuvposa" /><meta name="citation_keywords" content="Seebri" /><meta name="citation_keywords" content="Seebri Neohaler" /><meta name="citation_keywords" content="Glycopyrronii bromidum" /><meta name="citation_keywords" content="Lonhala Magnair" /><meta name="citation_keywords" content="596-51-0" /><meta name="citation_keywords" content="ROBINUL FORTE" /><meta name="citation_keywords" content="Bromuro de glicopirronio" /><meta name="citation_keywords" content="Bromure de glycopyrronium" /><meta name="citation_keywords" content="AHR-504" /><meta name="citation_keywords" content="QBREXZA" /><meta name="citation_keywords" content="glycopyrronium" /><meta name="citation_keywords" content="AHR 504" /><meta name="citation_keywords" content="NVA 237" /><meta name="citation_keywords" content="Glycopyrronii bromidum [INN-Latin]" /><meta name="citation_keywords" content="NSC 250836" /><meta name="citation_keywords" content="NSC 251251" /><meta name="citation_keywords" content="NSC 251252" /><meta name="citation_keywords" content="EINECS 209-887-0" /><meta name="citation_keywords" content="Bromure de glycopyrronium [INN-French]" /><meta name="citation_keywords" content="Bromuro de glicopirronio [INN-Spanish]" /><meta name="citation_keywords" content="3-Hydroxy-1,1-dimethylpyrrolidinium bromide alpha-cyclopentylmandelate" /><meta name="citation_keywords" content="1,1-Dimethyl-3-hydroxypyrrolidinium bromide alpha-cyclopentylmandelate" /><meta name="citation_keywords" content="1-Methyl-3-pyrrolidyl alpha-phenylcyclopentaneglycolate methobromide" /><meta name="citation_keywords" content="Pyrrolidinium, 3-((cyclopentylhydroxyphenylacetyl)oxy)-1,1-dimethyl-, bromide" /><meta name="citation_keywords" content="Pyrrolidinium, 1,1-dimethyl-3-hydroxy-, bromide, alpha-cyclopentylmandelate" /><meta name="citation_keywords" content="Pyrrolidinium, 3-hydroxy-1,1-dimethyl-, bromide, alpha-cyclopentylmandelate (8CI)" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Glycopyrrolate" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Child Health and Human Development" /><meta name="DC.Date" content="2022/11/30" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK501480/" /><meta name="description" content="No information is available on the use of glycopyrrolate during breastfeeding. Because glycopyrrolate is a quaternary ammonium compound, it is not likely to be absorbed and reach the bloodstream of the infant, especially when given by inhalation or topically on the skin.[1-3] Long-term oral use of glycopyrrolate might reduce milk production or milk letdown, but a single dose is unlikely to interfere with breastfeeding. During long-term use, observe for signs of decreased lactation such as poor weight gain." /><meta name="og:title" content="Glycopyrrolate" /><meta name="og:type" content="book" /><meta name="og:description" content="No information is available on the use of glycopyrrolate during breastfeeding. Because glycopyrrolate is a quaternary ammonium compound, it is not likely to be absorbed and reach the bloodstream of the infant, especially when given by inhalation or topically on the skin.[1-3] Long-term oral use of glycopyrrolate might reduce milk production or milk letdown, but a single dose is unlikely to interfere with breastfeeding. 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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK501480_"><span class="title" itemprop="name">Glycopyrrolate</span></h1><p class="small">Last Revision: <span itemprop="dateModified">November 30, 2022</span>.</p><p><em>Estimated reading time: 1 minute</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 596-51-0</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134975778" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134975778" alt="image 134975778 in the ncbi pubchem database" /></a><div id="LM594.Drug_Levels_and_Effects"><h2 id="_LM594_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM594.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>No information is available on the use of glycopyrrolate during breastfeeding. Because glycopyrrolate is a quaternary ammonium compound, it is not likely to be absorbed and reach the bloodstream of the infant, especially when given by inhalation or topically on the skin.[<a class="bk_pop" href="#LM594.REF.1">1</a>-<a class="bk_pop" href="#LM594.REF.3">3</a>] Long-term oral use of glycopyrrolate might reduce milk production or milk letdown, but a single dose is unlikely to interfere with breastfeeding. During long-term use, observe for signs of decreased lactation such as poor weight gain.</p></div><div id="LM594.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Relevant published information was not found as of the revision date.</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM594.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM594.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information in nursing mothers was not found as of the revision date. Anticholinergics can inhibit lactation in animals, apparently by inhibiting growth hormone and oxytocin secretion.[<a class="bk_pop" href="#LM594.REF.4">4</a>-<a class="bk_pop" href="#LM594.REF.8">8</a>] Anticholinergic drugs can also reduce serum prolactin in nonnursing women.[<a class="bk_pop" href="#LM594.REF.9">9</a>] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.</p></div><div id="LM594.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="LM594.REF.1">Hale TW. Anesthetic medications in breastfeeding mothers. <span><span class="ref-journal">J Hum Lact. </span>1999;<span class="ref-vol">15</span>:185–94.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/10578796" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 10578796</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="LM594.REF.2">Lee JJ, Rubin AP. Breast feeding and anaesthesia. <span><span class="ref-journal">Anaesthesia. </span>1993;<span class="ref-vol">48</span>:616–25.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/8346780" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 8346780</span></a>]</div></dd><dt>3.</dt><dd><div class="bk_ref" id="LM594.REF.3">Dalal PG, Bosak J, Berlin C. Safety of the breast-feeding infant after maternal anesthesia. <span><span class="ref-journal">Paediatr Anaesth. </span>2014;<span class="ref-vol">24</span>:359–71.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/24372776" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24372776</span></a>]</div></dd><dt>4.</dt><dd><div class="bk_ref" id="LM594.REF.4">Powell MR, Keisler DH. A potential strategy for decreasing milk production in the ewe at weaning using a growth hormone release blocker. <span><span class="ref-journal">J Anim Sci. </span>1995;<span class="ref-vol">73</span>:1901–5.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/7592071" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 7592071</span></a>]</div></dd><dt>5.</dt><dd><div class="bk_ref" id="LM594.REF.5">Aaron DK, Ely DG, Deweese WP, et al. Reducing milk production in ewes at weaning using restricted feeding and methscopolamine bromide. <span><span class="ref-journal">J Anim Sci. </span>1997;<span class="ref-vol">75</span>:1434–42.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/9250502" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9250502</span></a>]</div></dd><dt>6.</dt><dd><div class="bk_ref" id="LM594.REF.6">Daniel JA, Thomas MG, Powell MR, et al. Methscopolamine bromide blocks hypothalmic-stimulated release of growth hormone in ewes. <span><span class="ref-journal">J Anim Sci. </span>1997;<span class="ref-vol">75</span>:1359–62.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/9159285" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9159285</span></a>]</div></dd><dt>7.</dt><dd><div class="bk_ref" id="LM594.REF.7">Bizzarro A, Iannucci F, Tolino A, et al. Inhibiting effect of atropine on prolactin blood levels after stimulation with TRH. <span><span class="ref-journal">Clin Exp Obstet Gynecol. </span>1980;<span class="ref-vol">7</span>:108–11.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/6788407" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 6788407</span></a>]</div></dd><dt>8.</dt><dd><div class="bk_ref" id="LM594.REF.8">Svennersten K, Nelson L, Juvnäs-Moberg K. Atropinization decreases oxytocin secretion in dairy cows. <span><span class="ref-journal">Acta Physiol Scand. </span>1992;<span class="ref-vol">145</span>:193–4.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/1636447" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 1636447</span></a>]</div></dd><dt>9.</dt><dd><div class="bk_ref" id="LM594.REF.9">Masala A, Alagna S, Devilla L, et al. Muscarinic receptor blockade by pirenzepine: Effect on prolactin secretion in man. <span><span class="ref-journal">J Endocrinol Invest. </span>1982;<span class="ref-vol">5</span>:53–5.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/6808052" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 6808052</span></a>]</div></dd></dl></div></div><div id="LM594.Substance_Identification"><h2 id="_LM594_Substance_Identification_">Substance Identification</h2><div id="LM594.Substance_Name"><h3>Substance Name</h3><p>Glycopyrrolate</p></div><div id="LM594.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>596-51-0</p></div><div id="LM594.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Adjuvants, Anesthesia</p><p>Bronchodilator Agents</p><p>Muscarinic Antagonists</p><p>Parasympatholytics</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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