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class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK501479_"><span class="title" itemprop="name">Meprobamate</span></h1><p class="fm-aai"><a href="#_NBK501479_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 2 minutes</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><p>CASRN: 57-53-4</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134971019" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134971019" alt="image 134971019 in the ncbi pubchem database" /></a><div id="LM593.Drug_Levels_and_Effects"><h2 id="_LM593_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM593.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>If meprobamate is required by the mother, it is not necessarily a reason to discontinue breastfeeding. However, because there is little published experience with meprobamate during breastfeeding, other agents may be preferred, especially while nursing a newborn or preterm infant, or when other drugs that can cause sedation are used simultaneously. Monitor the infant for sedation, poor feeding and poor weight gain.</p></div><div id="LM593.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> One author reported a personal communication from the manufacturer. The manufacturer reports that 6 lactating women who were given a single 800 mg oral dose of meprobamate had peak milk meprobamate concentrations 4 hours after the dose.[<a class="bibr" href="#LM593.REF.1" rid="LM593.REF.1">1</a>]</p><p>The muscle relaxant carisoprodol is metabolized to meprobamate. A mother taking carisoprodol 700 mg three times daily during pregnancy and lactation had trough breastmilk levels of carisoprodol and meprobamate measured before the first morning dose on 4 consecutive days at steady-state (time postpartum not stated). Average minimum breastmilk levels were 0.9 mg/L for carisoprodol and 11.6 mg/L for meprobamate. The authors calculated that the minimum infant dose of the drug plus metabolite was 1.9 mg/kg daily or 4.1% of the maternal weight-adjusted dosage. Extrapolating these results to an average (rather than minimum) dose, the authors estimated that an exclusively breastfed infant would receive 3 mg/kg daily or 6% of the maternal weight-adjusted dosage.[<a class="bibr" href="#LM593.REF.2" rid="LM593.REF.2">2</a>]</p><p>A woman who was suspected to have been abusing carisoprodol had the drug and meprobamate detectable in breastmilk for 2 consecutive days after hospitalization; only meprobamate was detectable on day 3.[<a class="bibr" href="#LM593.REF.3" rid="LM593.REF.3">3</a>]</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM593.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>A mother taking carisoprodol 700 mg plus propoxyphene 70 mg and acetaminophen 900 mg 3 times daily and partially breastfeeding her infant noticed no unusual behavior or adverse reactions in her infant. The infant grew normally and, at 6 months of age, examination by a pediatrician found normal psychomotor development.[<a class="bibr" href="#LM593.REF.2" rid="LM593.REF.2">2</a>]</p></div><div id="LM593.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>One paper reported that some psychiatric patients receiving meprobamate alone or in combination with other psychotropic drugs developed galactorrhea. Further details of meprobamate use were not reported.[<a class="bibr" href="#LM593.REF.4" rid="LM593.REF.4">4</a>]</p></div><div id="LM593.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p><a href="/books/n/lactmed/LM364/?report=reader">Lorazepam</a>, <a href="/books/n/lactmed/LM377/?report=reader">Oxazepam</a></p></div><div id="LM593.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="LM593.REF.1">Ayd FJ. Excretion of psychotropic drugs in human breast milk. <span><span class="ref-journal">Int Drug Ther Newsl. </span>1973;<span class="ref-vol">8</span>:33–40.</span></div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="LM593.REF.2">Nordeng H, Zahlsen K, Spigset O. Transfer of carisoprodol to breast milk. <span><span class="ref-journal">Ther Drug Monit. </span>2001;<span class="ref-vol">23</span>:298–300.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/11360042" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11360042</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="LM593.REF.3">Bailey DN, Briggs JR. Carisoprodol: An unrecognized drug of abuse. <span><span class="ref-journal">Am J Clin Pathol. </span>2002;<span class="ref-vol">117</span>:396–400.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/11888078" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11888078</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>4.</dt><dd><div class="bk_ref" id="LM593.REF.4">Hooper JH Jr, Welch VC, Shackelford RT. Abnormal lactation associated with tranquilizing drug therapy. <span><span class="ref-journal">JAMA. </span>1961;<span class="ref-vol">178</span>:506–7.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/14448766" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 14448766</span></a>]</div></dd></dl></dl></div></div><div id="LM593.Substance_Identification"><h2 id="_LM593_Substance_Identification_">Substance Identification</h2><div id="LM593.Substance_Name"><h3>Substance Name</h3><p>Meprobamate</p></div><div id="LM593.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>57-53-4</p></div><div id="LM593.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Anti-Anxiety Agents</p><p>Hypnotics and Sedatives</p><p>Muscle Relaxants, Central</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK501479_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">February 15, 2023</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Meprobamate. [Updated 2023 Feb 15].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/lactmed/LM1201/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/lactmed/LM169/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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