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<meta name="citation_title" content="Antipyrine">
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<meta name="citation_publisher" content="National Institute of Child Health and Human Development">
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<meta name="citation_date" content="2024/09/15">
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<meta name="citation_keywords" content="antipyrine">
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<meta name="citation_keywords" content="Phenazone">
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<meta name="citation_keywords" content="Antipyrin">
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<meta name="citation_keywords" content="Phenazon">
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<meta name="citation_keywords" content="Analgesine">
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<meta name="citation_keywords" content="Anodynine">
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<meta name="citation_keywords" content="Anodynin">
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<meta name="citation_keywords" content="Fenazone">
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<meta name="citation_keywords" content="Azophen">
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<meta name="citation_keywords" content="Antipirin">
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<meta name="citation_keywords" content="Phenozone">
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<meta name="citation_keywords" content="Pyrazophyl">
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<meta name="citation_keywords" content="Apirelina">
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<meta name="citation_keywords" content="Phenylone">
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<meta name="citation_keywords" content="Azophene">
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<meta name="citation_keywords" content="Methozin">
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<meta name="citation_keywords" content="Sedatine">
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<meta name="citation_keywords" content="Sedatin">
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<meta name="citation_keywords" content="Antipyrinum">
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<meta name="citation_keywords" content="Phenazonum">
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<meta name="citation_keywords" content="Azophenum">
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<meta name="citation_keywords" content="T3CHA1B51H">
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<meta name="citation_keywords" content="EC 200-486-6">
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<meta name="citation_keywords" content="1,5-dimethyl-2-phenylpyrazol-3-one">
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<meta name="DC.Title" content="Antipyrine">
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class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK501472_"><span class="title" itemprop="name">Antipyrine</span></h1><p class="fm-aai"><a href="#_NBK501472_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 1 minute</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><p>CASRN: 60-80-0</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134970706" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134970706" alt="image 134970706 in the ncbi pubchem database" /></a><div id="LM587.Drug_Levels_and_Effects"><h2 id="_LM587_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM587.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Antipyrine is considered unlikely to harm the infant.[<a class="bibr" href="#LM587.REF.1" rid="LM587.REF.1">1</a>] Because antipyrine is available in the US only in ear drops, it is unlikely to be absorbed by the mother and reach the breastmilk. No special precautions are required during maternal use of antipyrine-containing ear drops.</p></div><div id="LM587.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Antipyrine was given to 7 lactating women who were 2 to 19 months postpartum. Each woman drank a single oral dose of 18 mg/kg of antipyrine in solution. Peak milk levels usually occurred 10 minutes after ingestion and ranged from about 10 to 30 mg/L. The antipyrine half-life in milk averaged 11.6 hours (range 5.7 to 21.7 hours). The authors estimated that a fully breastfed infant would ingest 6.4 mg of antipyrine after this maternal dose or 0.59% of the maternal dose (not weight-adjusted). Two of the women who were studied before and after pregnancy indicated that antipyrine clearance might be increased by about two-fold during lactation.[<a class="bibr" href="#LM587.REF.1" rid="LM587.REF.1">1</a>]</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM587.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM587.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM587.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="LM587.REF.1">Berlin
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CM, Jr, Vesell
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S. Antipyrine disposition in milk and saliva of lactating women.
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Clin Pharmacol Ther
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1982;31:38-44.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/7053302" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 7053302</span></a>]</div></dd></dl></dl></div></div><div id="LM587.Substance_Identification"><h2 id="_LM587_Substance_Identification_">Substance Identification</h2><div id="LM587.Substance_Name"><h3>Substance Name</h3><p>Antipyrine</p></div><div id="LM587.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>60-80-0</p></div><div id="LM587.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Anti-Inflammatory Agents, Non-Steroidal</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK501472_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">September 15, 2024</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Antipyrine. [Updated 2024 Sep 15].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/lactmed/LM1253/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/lactmed/LM1036/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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