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class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK501449_"><span class="title" itemprop="name">Buspirone</span></h1><p class="fm-aai"><a href="#_NBK501449_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 2 minutes</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><p>CASRN: 36505-84-7</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134999311" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134999311" alt="image 134999311 in the ncbi pubchem database" /></a><div id="LM566.Drug_Levels_and_Effects"><h2 id="_LM566_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM566.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Limited information indicates that maternal doses of buspirone up to 45 mg daily produce low levels in milk. Because no information is available on the long-term use of buspirone during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.</p></div><div id="LM566.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> A woman was taking buspirone 15 mg 3 times daily during pregnancy and postpartum. On day 13 postpartum, buspirone was undetectable in breastmilk by HPLC assay (limit of detection and time of sample not stated).[<a class="bibr" href="#LM566.REF.1" rid="LM566.REF.1">1</a>]</p><p>Nine women taking buspirone 7.5 to 30 mg twice daily donated milk samples collected at 1, 2, 4, 6, 8, 10, and 12 hours after a dose to a human milk repository. Levels of buspirone and its active metabolite 1-(2-pyrimidinyl) piperazine were measured. Buspirone was not detected (<1.5 mcg/L) in any samples, but the metabolite was found in all samples. The relative infant dose was estimated to average 0.91% (range 0.21 to 2.17%).[<a class="bibr" href="#LM566.REF.2" rid="LM566.REF.2">2</a>]</p><p><i>Infant Levels.</i> In the exclusively breastfed infant of a mother who was taking buspirone 15 mg 3 times daily, buspirone was undetectable in the infant's serum by HPLC assay (limit of detection and time of sample not stated) on days 13 and 21 postpartum.[<a class="bibr" href="#LM566.REF.1" rid="LM566.REF.1">1</a>]</p></div><div id="LM566.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Possible drug-induced seizure-like activity and cyanosis occurred in a breastfed 3-week-old whose mother was taking buspirone 15 mg 3 times daily as well as fluoxetine and carbamazepine during pregnancy and breastfeeding. The authors thought that this reaction, if drug induced, was most likely caused by fluoxetine.[<a class="bibr" href="#LM566.REF.1" rid="LM566.REF.1">1</a>]</p><p>One exclusively breastfed 11-week-old infant was breastfed during maternal therapy with buspirone 10 mg daily and venlafaxine 300 mg daily. No adverse reactions were reported by the mother or in the medical records.[<a class="bibr" href="#LM566.REF.3" rid="LM566.REF.3">3</a>]</p></div><div id="LM566.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Buspirone increases serum prolactin.[<a class="bibr" href="#LM566.REF.4" rid="LM566.REF.4">4</a>-<a class="bibr" href="#LM566.REF.7" rid="LM566.REF.7">7</a>] Galactorrhea was reported in a woman taking venlafaxine after buspirone was added to her regimen. However, when buspirone was discontinued, galactorrhea persisted.[<a class="bibr" href="#LM566.REF.8" rid="LM566.REF.8">8</a>] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.</p></div><div id="LM566.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p><a href="/books/n/lactmed/LM364/?report=reader">Lorazepam</a>, <a href="/books/n/lactmed/LM377/?report=reader">Oxazepam</a></p></div><div id="LM566.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="LM566.REF.1">Brent
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NB, Wisner
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KL. Fluoxetine and carbamazepine concentrations in a nursing mother/infant pair.
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Clin Pediatr (Phila)
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1998;37:41-4
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[<a href="https://pubmed.ncbi.nlm.nih.gov/9475699" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9475699</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="LM566.REF.2">Krutsch
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K, Campbell
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L, Baker
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T, et al.
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Alleviating anxiety while breastfeeding: evaluating buspirone transfer into human milk.
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Arch Womens Ment Health
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2024;27:619–23
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[<a href="https://pubmed.ncbi.nlm.nih.gov/38376615" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 38376615</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="LM566.REF.3">Newport
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DJ, Ritchie
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JC, Knight
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BT, et al.
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Venlafaxine in human breast milk and nursing infant plasma: Determination of exposure.
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J Clin Psychiatry
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2009;70:1304-10
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[<a href="https://pubmed.ncbi.nlm.nih.gov/19607765" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19607765</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>4.</dt><dd><div class="bk_ref" id="LM566.REF.4">Bridge
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MW, Marvin
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G, Thompson
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CE, et al.
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Quantifying the 5-HT1a agonist action of buspirone in man.
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Psychopharmacology (Berl)
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2001;158:224-9
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[<a href="https://pubmed.ncbi.nlm.nih.gov/11713611" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11713611</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>5.</dt><dd><div class="bk_ref" id="LM566.REF.5">Gómez-Gil
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E, Navinés
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R, Martínez De Osaba, MJ, et al.
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Hormonal responses to the 5-HT1a agonist buspirone in remitted endogenous depressive patients after long-term imipramine treatment.
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Psychoneuroendocrinology
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2010;35:481-9
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[<a href="https://pubmed.ncbi.nlm.nih.gov/19762159" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19762159</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>6.</dt><dd><div class="bk_ref" id="LM566.REF.6">Maskall
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DD, Zis
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AP, Lam
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RW, et al.
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Prolactin response to buspirone challenge in the presence of dopaminergic blockade.
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Biol Psychiatry
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1995;38:235-9
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[<a href="https://pubmed.ncbi.nlm.nih.gov/8547445" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 8547445</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>7.</dt><dd><div class="bk_ref" id="LM566.REF.7">Navinés
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R, Gómez-Gil
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E, Martin-Santos
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R, et al.
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Hormonal response to buspirone is not impaired in major depression.
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Hum Psychopharmacol
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2007;22:389-95
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[<a href="https://pubmed.ncbi.nlm.nih.gov/17563921" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 17563921</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>8.</dt><dd><div class="bk_ref" id="LM566.REF.8">Sternbach
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H.
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Venlafaxine-induced galactorrhea.
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J Clin Psychopharmacol
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2003;23:109-10
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[<a href="https://pubmed.ncbi.nlm.nih.gov/12544389" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12544389</span></a>]</div></dd></dl></dl></div></div><div id="LM566.Substance_Identification"><h2 id="_LM566_Substance_Identification_">Substance Identification</h2><div id="LM566.Substance_Name"><h3>Substance Name</h3><p>Buspirone</p></div><div id="LM566.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>36505-84-7</p></div><div id="LM566.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Anti-Anxiety Agents</p><p>Serotonin Agonists</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK501449_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">July 15, 2024</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Buspirone. [Updated 2024 Jul 15].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/lactmed/LM1384/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/lactmed/LM37/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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