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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]" /><meta name="citation_title" content="Azelaic Acid" /><meta name="citation_publisher" content="National Institute of Child Health and Human Development" /><meta name="citation_date" content="2024/10/15" /><meta name="citation_pmid" content="30000482" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK501422/" /><meta name="citation_keywords" content="azelaic acid" /><meta name="citation_keywords" content="nonanedioic acid" /><meta name="citation_keywords" content="Finacea" /><meta name="citation_keywords" content="Anchoic acid" /><meta name="citation_keywords" content="Azelex" /><meta name="citation_keywords" content="Lepargylic acid" /><meta name="citation_keywords" content="Skinoren" /><meta name="citation_keywords" content="acide azelaique" /><meta name="citation_keywords" content="Acido azelaico" /><meta name="citation_keywords" content="acidum azelaicum" /><meta name="citation_keywords" content="Emerox 1110" /><meta name="citation_keywords" content="Emerox 1144" /><meta name="citation_keywords" content="UNII-F2VW3D43YT" /><meta name="citation_keywords" content="F2VW3D43YT" /><meta name="citation_keywords" content="NSC 19493" /><meta name="citation_keywords" content="HSDB 7659" /><meta name="citation_keywords" content="EINECS 204-669-1" /><meta name="citation_keywords" content="ZK 62498" /><meta name="citation_keywords" content="BRN 1101094" /><meta name="citation_keywords" content="AI3-06299" /><meta name="citation_keywords" content="EC 204-669-1" /><meta name="citation_keywords" content="4-02-00-02055 (Beilstein Handbook Reference)" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Azelaic Acid" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Child Health and Human Development" /><meta name="DC.Date" content="2024/10/15" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK501422/" /><meta name="description" content="Topical azelaic acid has not been studied during breastfeeding. Because only 4% of a dose is absorbed after topical application and it is a chemical that appears in foods, bloodstream and breastmilk normally, azelaic acid is considered a low risk to the nursing infant.[1-3] If azelaic acid is required by the mother, it is not a reason to discontinue breastfeeding. Do not apply azelaic acid to the breast or nipple and ensure that the infant's skin does not come into direct contact with the areas of skin that have been treated. Only water-miscible cream or gel products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.[4]" /><meta name="og:title" content="Azelaic Acid" /><meta name="og:type" content="book" /><meta name="og:description" content="Topical azelaic acid has not been studied during breastfeeding. Because only 4% of a dose is absorbed after topical application and it is a chemical that appears in foods, bloodstream and breastmilk normally, azelaic acid is considered a low risk to the nursing infant.[1-3] If azelaic acid is required by the mother, it is not a reason to discontinue breastfeeding. Do not apply azelaic acid to the breast or nipple and ensure that the infant's skin does not come into direct contact with the areas of skin that have been treated. Only water-miscible cream or gel products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.[4]" /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK501422/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-lactmed-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/lactmed/LM541/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK501422/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK501422_"><span class="title" itemprop="name">Azelaic Acid</span></h1><p class="small">Last Revision: <span itemprop="dateModified">October 15, 2024</span>.</p><p><em>Estimated reading time: 1 minute</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 123-99-9</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134974895" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134974895" alt="image 134974895 in the ncbi pubchem database" /></a><div id="LM541.Drug_Levels_and_Effects"><h2 id="_LM541_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM541.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Topical azelaic acid has not been studied during breastfeeding. Because only 4% of a dose is absorbed after topical application and it is a chemical that appears in foods, bloodstream and breastmilk normally, azelaic acid is considered a low risk to the nursing infant.[<a class="bk_pop" href="#LM541.REF.1">1</a>-<a class="bk_pop" href="#LM541.REF.3">3</a>] If azelaic acid is required by the mother, it is not a reason to discontinue breastfeeding. Do not apply azelaic acid to the breast or nipple and ensure that the infant's skin does not come into direct contact with the areas of skin that have been treated. Only water-miscible cream or gel products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.[<a class="bk_pop" href="#LM541.REF.4">4</a>]</p></div><div id="LM541.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Relevant published information was not found as of the revision date.</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM541.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM541.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM541.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p>(Acne) <a href="/books/n/lactmed/LM540/">Benzoyl Peroxide</a>, <a href="/books/n/lactmed/LM343/">Clindamycin</a>, <a href="/books/n/lactmed/LM351/">Erythromycin</a>, <a href="/books/n/lactmed/LM539/">Tretinoin</a>; (Rosacea) <a href="/books/n/lactmed/LM440/">Metronidazole</a></p></div><div id="LM541.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="LM541.REF.1">Akhavan
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A, Bershad
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S.
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Topical acne drugs: Review of clinical properties, systemic exposure, and safety.
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Am J Clin Dermatol
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2003;4:473-92.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/12814337" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12814337</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="LM541.REF.2">Leachman
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SA, Reed
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BR. The use of dermatologic drugs in pregnancy and lactation.
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Dermatol Clin
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2006;24:167-97.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/16677965" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16677965</span></a>]</div></dd><dt>3.</dt><dd><div class="bk_ref" id="LM541.REF.3">Yaghi
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M, McMullan
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P, Truong
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TM, et al.
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Safety of dermatologic medications in pregnancy and lactation: An Update - Part II: Lactation.
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J Am Acad Dermatol
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2024;91:651-68.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/38280680" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 38280680</span></a>]</div></dd><dt>4.</dt><dd><div class="bk_ref" id="LM541.REF.4">Noti
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A, Grob
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K, Biedermann
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M, et al.
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Exposure of babies to C(15)-C(45) mineral paraffins from human milk and breast salves.
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Regul Toxicol Pharmacol
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2003;38:317-25.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/14623482" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 14623482</span></a>]</div></dd></dl></div></div><div id="LM541.Substance_Identification"><h2 id="_LM541_Substance_Identification_">Substance Identification</h2><div id="LM541.Substance_Name"><h3>Substance Name</h3><p>Azelaic Acid</p></div><div id="LM541.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>123-99-9</p></div><div id="LM541.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Antineoplastic Agents</p><p>Dermatologic Agents</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div><div class="small"><span class="label">Bookshelf ID: NBK501422</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/30000482" title="PubMed record of this page" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">30000482</a></span></div><div style="margin-top:2em" class="bk_noprnt"><a class="bk_cntns" href="/books/n/lactmed/">Contents</a><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/lactmed/LM20/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/lactmed/LM21/" title="Next page in this title">Next ></a></div></div></div></div>
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