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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]" /><meta name="citation_title" content="Fluorescein" /><meta name="citation_publisher" content="National Institute of Child Health and Human Development" /><meta name="citation_date" content="2024/08/15" /><meta name="citation_pmid" content="30000477" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK501417/" /><meta name="citation_keywords" content="fluorescein" /><meta name="citation_keywords" content="Resorcinolphthalein" /><meta name="citation_keywords" content="Fluoresceine" /><meta name="citation_keywords" content="Yellow fluorescein" /><meta name="citation_keywords" content="Solvent Yellow 94" /><meta name="citation_keywords" content="Fluorescite" /><meta name="citation_keywords" content="3,6-Fluorandiol" /><meta name="citation_keywords" content="Fluorescein acid" /><meta name="citation_keywords" content="Japan Yellow 201" /><meta name="citation_keywords" content="D&C Yellow No. 7" /><meta name="citation_keywords" content="Fluorescein Red" /><meta name="citation_keywords" content="Soap Yellow F" /><meta name="citation_keywords" content="D and C Yellow No. 7" /><meta name="citation_keywords" content="Hidacid fluorescein" /><meta name="citation_keywords" content="3',6'-Dihydroxyfluoran" /><meta name="citation_keywords" content="Zlut kysela 73" /><meta name="citation_keywords" content="D & C Yellow no. 7" /><meta name="citation_keywords" content="D+C Yellow No. 7" /><meta name="citation_keywords" content="11712 Yellow" /><meta name="citation_keywords" content="UNII-TPY09G7XIR" /><meta name="citation_keywords" content="TPY09G7XIR" /><meta name="citation_keywords" content="Zlut kysela 73 [Czech]" /><meta name="citation_keywords" content="Fluoran, 3',6'-dihydroxy-" /><meta name="citation_keywords" content="CCRIS 7076" /><meta name="citation_keywords" content="HSDB 2128" /><meta name="citation_keywords" content="NSC 667256" /><meta name="citation_keywords" content="EINECS 219-031-8" /><meta name="citation_keywords" content="BRN 0094324" /><meta name="citation_keywords" content="C.I. 45350:1" /><meta name="citation_keywords" content="CI 45350:1" /><meta name="citation_keywords" content="EC 219-031-8" /><meta name="citation_keywords" content="5-19-06-00456 (Beilstein Handbook Reference)" /><meta name="citation_keywords" content="3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Fluorescein" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Child Health and Human Development" /><meta name="DC.Date" content="2024/08/15" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK501417/" /><meta name="description" content="Because absorption from the eye is limited, fluorescein would not be expected to cause any adverse effects in breastfed infants. To substantially diminish the amount of drug that reaches the breastmilk after using eye drops, place pressure over the tear duct by the corner of the eye for 1 minute or more, then remove the excess solution with an absorbent tissue." /><meta name="og:title" content="Fluorescein" /><meta name="og:type" content="book" /><meta name="og:description" content="Because absorption from the eye is limited, fluorescein would not be expected to cause any adverse effects in breastfed infants. To substantially diminish the amount of drug that reaches the breastmilk after using eye drops, place pressure over the tear duct by the corner of the eye for 1 minute or more, then remove the excess solution with an absorbent tissue." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK501417/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-lactmed-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/lactmed/LM537/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK501417/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK501417_"><span class="title" itemprop="name">Fluorescein</span></h1><p class="small">Last Revision: <span itemprop="dateModified">August 15, 2024</span>.</p><p><em>Estimated reading time: 1 minute</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 2321-07-5</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134983034" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134983034" alt="image 134983034 in the ncbi pubchem database" /></a><div id="LM537.Drug_Levels_and_Effects"><h2 id="_LM537_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM537.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Because absorption from the eye is limited, fluorescein would not be expected to cause any adverse effects in breastfed infants. To substantially diminish the amount of drug that reaches the breastmilk after using eye drops, place pressure over the tear duct by the corner of the eye for 1 minute or more, then remove the excess solution with an absorbent tissue.</p><p>After intravenous use in a nursing mother, milk levels and the dose received by the infant are much higher than with ophthalmic use. It is unlikely that these higher levels are problematic for most infants, but exposure to intense light, such as phototherapy, should probably be avoided for a few days after the maternal dose.</p></div><div id="LM537.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> A woman received 5 mL of 10% fluorescein (500 mg) injection shortly after delivering a set of twins. Milk samples were obtained periodically by manual expression for 76 hours after the dose. The highest concentration of 372 mcg/L was obtained in the first sample 6 hours after the dose. By 76 hours after the dose, the milk fluorescein concentration was 170 mcg/L. The half-life of fluorescein in milk was 62 hours.[<a class="bk_pop" href="#LM537.REF.1">1</a>]</p><p>A mother nursing a 3-month-old infant had 2% fluorescein drops applied into each eye. Blood and milk samples were taken 3 times at 30-minute intervals after the dose. Milk levels at these times were 20, 22 and 15 mcg/L, respectively.[<a class="bk_pop" href="#LM537.REF.2">2</a>]</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM537.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM537.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM537.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="LM537.REF.1">Maguire
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AM, Bennett
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J. Fluorescein elimination in human breast milk.
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Arch Ophthalmol
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1988;106:718-9.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/3369981" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 3369981</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="LM537.REF.2">Mattern
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J, Mayer
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PR. Excretion of fluorescein into breast milk.
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Am J Ophthalmol
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1990;109:598-9.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/2333925" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 2333925</span></a>]</div></dd></dl></div></div><div id="LM537.Substance_Identification"><h2 id="_LM537_Substance_Identification_">Substance Identification</h2><div id="LM537.Substance_Name"><h3>Substance Name</h3><p>Fluorescein</p></div><div id="LM537.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>2321-07-5</p></div><div id="LM537.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Contrast Media</p><p>Diagnostic Agents</p><p>Fluorescent Dyes</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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