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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK501416_"><span class="title" itemprop="name">Simethicone</span></h1><p class="small">Last Revision: <span itemprop="dateModified">March 17, 2021</span>.</p><p><em>Estimated reading time: 1 minute</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 8050-81-5</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134990626" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134990626" alt="image 134990626 in the ncbi pubchem database" /></a><div id="LM536.Drug_Levels_and_Effects"><h2 id="_LM536_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM536.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Although no data are available on the use of simethicone during breastfeeding, it is known that simethicone is not absorbed orally. Therefore, it cannot be transferred to breastmilk. It is also used safely in breastfed infants.[<a class="bk_pop" href="#LM536.REF.1">1</a>,<a class="bk_pop" href="#LM536.REF.2">2</a>] No special precautions are required.</p></div><div id="LM536.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Relevant published information was not found as of the revision date.</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM536.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM536.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM536.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="LM536.REF.1">Hagemann TM. Gastrointestinal medications and breastfeeding. <span><span class="ref-journal">J Hum Lact. </span>1998;<span class="ref-vol">14</span>:259–62.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/10205441" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 10205441</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="LM536.REF.2">Savino F, Pelle E, Palumeri E, et al. <em>Lactobacillus reuteri</em> (American Type Culture Collection Strain 55730) versus simethicone in the treatment of infantile colic: A prospective randomized study. <span><span class="ref-journal">Pediatrics. </span>2007;<span class="ref-vol">119</span>:e124–30.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/17200238" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 17200238</span></a>]</div></dd></dl></div></div><div id="LM536.Substance_Identification"><h2 id="_LM536_Substance_Identification_">Substance Identification</h2><div id="LM536.Substance_Name"><h3>Substance Name</h3><p>Simethicone</p></div><div id="LM536.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>8050-81-5</p></div><div id="LM536.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Antifoaming Agents</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div><div class="small"><span class="label">Bookshelf ID: NBK501416</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/30000476" title="PubMed record of this page" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">30000476</a></span></div><div style="margin-top:2em" class="bk_noprnt"><a class="bk_cntns" href="/books/n/lactmed/">Contents</a><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/lactmed/LM1243/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/lactmed/LM484/" title="Next page in this title">Next ></a></div></div></div></div>
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