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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Iothalamate - Drugs and Lactation Database (LactMed®) - NCBI Bookshelf</title>
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<meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]">
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<meta name="citation_title" content="Iothalamate">
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<meta name="citation_date" content="2022/11/30">
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<meta name="citation_keywords" content="Natrii amidotrizoas">
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<meta name="citation_keywords" content="Diatrizoate sodium salt">
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<meta name="citation_keywords" content="Diatrizoic acid sodium salt">
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<meta name="citation_keywords" content="Amidotrizoate de sodium">
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<meta name="citation_keywords" content="Diatrizoate sodium [USP]">
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<meta name="citation_keywords" content="Sodium 3,5-diacetamido-2,4,6-triiodobenzoate">
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<meta name="citation_keywords" content="3,5-Diacetylamino-2,4,6-trijodbenzosaeure natrium">
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<meta name="citation_keywords" content="Benzoic acid, 3,5-bis(acetylamino)-2,4,6-triiodo-, monosodium salt">
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<meta name="citation_keywords" content="3,5-Diacetamido-2,4,6-triiodobenzoic acid, sodium salt">
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<meta name="citation_keywords" content="Benzoic acid, 3,5-diacetamido-2,4,6-triiodo-, sodium salt">
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<meta name="DC.Title" content="Iothalamate">
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<meta name="og:description" content="Intravenous iodinated contrast media are poorly excreted into breastmilk and poorly absorbed orally so they are not likely to reach the bloodstream of the infant or cause any adverse effects in breastfed infants. Guidelines developed by several professional organizations state that breastfeeding need not be disrupted after a nursing mother receives an iodine-containing contrast medium.[1-4] However, because there is no published experience with iothalamate during breastfeeding, other agents may be preferred, especially while nursing a newborn or preterm infant.">
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class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK501405_"><span class="title" itemprop="name">Iothalamate</span></h1><p class="fm-aai"><a href="#_NBK501405_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 1 minute</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><p>CASRN: 737-31-5</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134976261" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134976261" alt="image 134976261 in the ncbi pubchem database" /></a><div id="LM526.Drug_Levels_and_Effects"><h2 id="_LM526_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM526.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Intravenous iodinated contrast media are poorly excreted into breastmilk and poorly absorbed orally so they are not likely to reach the bloodstream of the infant or cause any adverse effects in breastfed infants. Guidelines developed by several professional organizations state that breastfeeding need not be disrupted after a nursing mother receives an iodine-containing contrast medium.[<a class="bibr" href="#LM526.REF.1" rid="LM526.REF.1">1</a>-<a class="bibr" href="#LM526.REF.4" rid="LM526.REF.4">4</a>] However, because there is no published experience with iothalamate during breastfeeding, other agents may be preferred, especially while nursing a newborn or preterm infant.</p></div><div id="LM526.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Relevant published information was not found as of the revision date.</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM526.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM526.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM526.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p><a href="/books/n/lactmed/LM528/?report=reader">Diatrizoate</a>, <a href="/books/n/lactmed/LM527/?report=reader">Iohexol</a></p></div><div id="LM526.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="LM526.REF.1">Webb JA, Thomsen HS, Morcos SK, et al. The use of iodinated and gadolinium contrast media during pregnancy and lactation. <span><span class="ref-journal">Eur Radiol. </span>2005;<span class="ref-vol">15</span>:1234–40.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15609057" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15609057</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="LM526.REF.2">Chen MM, Coakley FV, Kaimal A, et al. Guidelines for computed tomography and magnetic resonance imaging use during pregnancy and lactation. <span><span class="ref-journal">Obstet Gynecol. </span>2008;<span class="ref-vol">112</span>:333–40.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/18669732" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18669732</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="LM526.REF.3">Copel J, El-Sayed Y, Heine RP, et al. Committee Opinion No. 723: Guidelines for diagnostic imaging during pregnancy and lactation. <span><span class="ref-journal">Obstet Gynecol. </span>2017;<span class="ref-vol">130</span>:e210–e216.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/28937575" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28937575</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>4.</dt><dd><div class="bk_ref" id="LM526.REF.4">American College of Radiology Committee on Drugs and Contrast Media. Administration of contrast media to breast-feeding mothers. In, ACR manual on contrast media. 2022;Version 2022:106-7. <a href="https://www.acr.org/Clinical-Resources/Contrast-Manual" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">https://www<wbr style="display:inline-block"></wbr>​.acr.org/Clinical-Resources<wbr style="display:inline-block"></wbr>​/Contrast-Manual</a>.</div></dd></dl></dl></div></div><div id="LM526.Substance_Identification"><h2 id="_LM526_Substance_Identification_">Substance Identification</h2><div id="LM526.Substance_Name"><h3>Substance Name</h3><p>Iothalamate</p></div><div id="LM526.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>737-31-5</p></div><div id="LM526.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Diagnostic Media</p><p>Contrast Agents</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK501405_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">November 30, 2022</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Iothalamate. [Updated 2022 Nov 30].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/lactmed/LM530/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/lactmed/LM1136/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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