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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Permethrin - Drugs and Lactation Database (LactMed®) - NCBI Bookshelf</title>
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<meta name="citation_title" content="Permethrin">
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<meta name="citation_keywords" content="Ambush">
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<meta name="citation_keywords" content="Acticin">
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<meta name="citation_keywords" content="Health Mart Lice Treatment">
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<meta name="citation_keywords" content="Pounce">
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<meta name="citation_keywords" content="Permethrinum">
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<meta name="citation_keywords" content="Permethrine">
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<meta name="citation_keywords" content="Permetrina">
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<meta name="citation_keywords" content="Ambushfog">
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<meta name="citation_keywords" content="Chinetrin">
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<meta name="citation_keywords" content="Efmethrin">
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<meta name="citation_keywords" content="Indothrin">
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<meta name="citation_keywords" content="Outflank">
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<meta name="citation_keywords" content="Permasect">
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<meta name="citation_keywords" content="Perthrine">
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<meta name="citation_keywords" content="Stomoxin">
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<meta name="citation_keywords" content="Stomozan">
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<meta name="citation_keywords" content="Ipitox">
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<meta name="DC.Title" content="Permethrin">
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<meta name="description" content="Because less than 2% is absorbed after topical application, rapid metabolism to inactive metabolites and safe application directly on infants' skin, topical permethrin products are acceptable in nursing mothers.[1-4] Extensive exposure, such as from agricultural use or malaria control might have long-term health concerns because residues can be found in breastmilk.[5] Only water-miscible cream, gel or liquid products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.[6]">
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<meta name="og:description" content="Because less than 2% is absorbed after topical application, rapid metabolism to inactive metabolites and safe application directly on infants' skin, topical permethrin products are acceptable in nursing mothers.[1-4] Extensive exposure, such as from agricultural use or malaria control might have long-term health concerns because residues can be found in breastmilk.[5] Only water-miscible cream, gel or liquid products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.[6]">
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class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK501383_"><span class="title" itemprop="name">Permethrin</span></h1><p class="fm-aai"><a href="#_NBK501383_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 3 minutes</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><p>CASRN: 52645-53-1</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/135003399" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=135003399" alt="image 135003399 in the ncbi pubchem database" /></a><div id="LM505.Drug_Levels_and_Effects"><h2 id="_LM505_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM505.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Because less than 2% is absorbed after topical application, rapid metabolism to inactive metabolites and safe application directly on infants' skin, topical permethrin products are acceptable in nursing mothers.[<a class="bibr" href="#LM505.REF.1" rid="LM505.REF.1">1</a>-<a class="bibr" href="#LM505.REF.4" rid="LM505.REF.4">4</a>] Extensive exposure, such as from agricultural use or malaria control might have long-term health concerns because residues can be found in breastmilk.[<a class="bibr" href="#LM505.REF.5" rid="LM505.REF.5">5</a>] Only water-miscible cream, gel or liquid products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.[<a class="bibr" href="#LM505.REF.6" rid="LM505.REF.6">6</a>]</p></div><div id="LM505.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Permethrin was measured in 53 breastmilk samples from 29 mothers collected 1998 to 1999 in Basel Switzerland. Permethrin was detected in 25 milk samples, even in mothers from households that reported no permethrin use. The average permethrin concentration was 74 mcg/kg of fat (range undetectable [<60 mcg/kg] to 152 mcg/kg fat).[<a class="bibr" href="#LM505.REF.7" rid="LM505.REF.7">7</a>]</p><p>Permethrin was found in the breastmilk of nursing mothers in 3 South African towns. Average levels in breastmilk ranged from 8.3 to 48.4 mcg/L in the 3 towns. The source was thought to be from a dusting powder widely available and used in gardening. The dosage and route of exposure (i.e., topical, inhalation, oral) could not be determined. All milk levels were below the allowable daily limit for permethrin.[<a class="bibr" href="#LM505.REF.8" rid="LM505.REF.8">8</a>,<a class="bibr" href="#LM505.REF.9" rid="LM505.REF.9">9</a>]</p><p>Samples of mature milk were collected in 2002 from 22 mothers in Mozambique where pyrethrins were used for mosquito control in the thatching of homes from 1993 to 2000 and continued to be used in bed netting after this period. The average permethrin concentration in the milk samples was 79 mcg/kg of lipid; the median concentration was 55 mcg/kg of lipid (range 10 to 230 mcg/kg of lipid). The milk permethrin levels in all mothers were below the allowable daily limit for permethrin.[<a class="bibr" href="#LM505.REF.10" rid="LM505.REF.10">10</a>]</p><p>Breastmilk samples from mothers in Brazil, Colombia and Spain were analyzed for pyrethroids. Permethrin was detected in all samples, regardless of reported household usage. Samples from rural Brazil (n = 9) contained a mean permethrin concentration of 3.57 ng/gram of lipid. Samples from Sao Paulo (n = 8) contained a mean permethrin concentration of 0.36 ng/gram of lipid. Samples from Santiago de Cali, Colombia (n = 27) contained a mean permethrin concentration of 0.91 ng/gram of lipid. Samples from Barcelona, Spain (n = 6) contained a mean permethrin concentration of 2.2 ng/gram of lipid. Other pyrethroids were also detected, but estimated daily intakes by breastfed infants were all below acceptable daily intake limits.[<a class="bibr" href="#LM505.REF.11" rid="LM505.REF.11">11</a>]</p><p>Breastmilk samples from 79 women from a lactation study at the University of California Davis had their breastmilk tested for the presence of trans-permethrin on day 42 postpartum. The mean concentration found was 7.8 mcg/L (range 0.43 to 150.3 mcg/L).[<a class="bibr" href="#LM505.REF.12" rid="LM505.REF.12">12</a>]</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM505.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>In a telephone follow-up study, 5 mothers who used permethrin during breastfeeding reported no adverse reactions in their breastfed infants.[<a class="bibr" href="#LM505.REF.13" rid="LM505.REF.13">13</a>]</p></div><div id="LM505.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM505.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p><a href="/books/n/lactmed/LM499/?report=reader">Ivermectin</a>, <a href="/books/n/lactmed/LM734/?report=reader">Pyrethrins</a></p></div><div id="LM505.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="LM505.REF.1">Porto
|
|
I.
|
|
Antiparasitic drugs and lactation: Focus on anthelmintics, scabicides, and pediculicides.
|
|
J Hum Lact
|
|
2003;19:421-5.
|
|
[<a href="https://pubmed.ncbi.nlm.nih.gov/14620457" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 14620457</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="LM505.REF.2">Leachman
|
|
S, Reed
|
|
B. The use of dermatologic drugs in pregnancy and lactation.
|
|
Dermatol Clin
|
|
2006;24:167-97.
|
|
[<a href="https://pubmed.ncbi.nlm.nih.gov/16677965" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16677965</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="LM505.REF.3">Salavastru
|
|
C, Chosidow
|
|
O, Boffa
|
|
M, et al.
|
|
European guideline for the management of scabies.
|
|
J Eur Acad Dermatol Venereol
|
|
2017;31:1248-53.
|
|
[<a href="https://pubmed.ncbi.nlm.nih.gov/28639722" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28639722</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>4.</dt><dd><div class="bk_ref" id="LM505.REF.4">Morand
|
|
A, Weill
|
|
A, Miquel
|
|
J, et al.
|
|
Management of scabies in children under 15 kg and pregnant or breastfeeding women: recommendations supported by the Centre of Evidence of the French Society of Dermatology.
|
|
Br J Dermatol
|
|
2024;191:1014-16.
|
|
[<a href="https://pubmed.ncbi.nlm.nih.gov/39028660" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 39028660</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>5.</dt><dd><div class="bk_ref" id="LM505.REF.5">Bouwman
|
|
H, Kylin
|
|
H. Malaria control insecticide residues in breast milk: the need to consider infant health risks.
|
|
Environ Health Perspect
|
|
2009;117:1477-80.
|
|
[<a href="/pmc/articles/PMC2790498/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC2790498</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/20019894" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 20019894</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>6.</dt><dd><div class="bk_ref" id="LM505.REF.6">Noti
|
|
A, Grob
|
|
K, Biedermann
|
|
M, et al.
|
|
Exposure of babies to C(15)-C(45) mineral paraffins from human milk and breast salves.
|
|
Regul Toxicol Pharmacol
|
|
2003;38:317-25.
|
|
[<a href="https://pubmed.ncbi.nlm.nih.gov/14623482" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 14623482</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>7.</dt><dd><div class="bk_ref" id="LM505.REF.7">Zehringer
|
|
M, Herrmann
|
|
A. Analysis of polychlorinated biphenyls, pyrethroid insecticides and fragrances in human milk using a laminar cup liner in the GC injector.
|
|
Eur Food Res Technol
|
|
2001;212:247-51. doi:10.1007/s002170000223 [<a href="http://dx.crossref.org/10.1007/s002170000223" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">CrossRef</a>]</div></dd></dl><dl class="bkr_refwrap"><dt>8.</dt><dd><div class="bk_ref" id="LM505.REF.8">Sereda
|
|
B, Bouwman
|
|
H, Kylin
|
|
H. Comparing water, bovine milk, and indoor residual spraying as possible sources of DDT and pyrethroid residues in breast milk.
|
|
J Toxicol Environ Health A
|
|
2009;72:842-51.
|
|
[<a href="https://pubmed.ncbi.nlm.nih.gov/19557612" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19557612</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>9.</dt><dd><div class="bk_ref" id="LM505.REF.9">Bouwman
|
|
H, Sereda
|
|
B, Meinhardt
|
|
H.
|
|
Simultaneous presence of DDT and pyrethroid residues in human breast milk from a malaria endemic area in South Africa.
|
|
Environ Pollut
|
|
2006;144:902-17.
|
|
[<a href="https://pubmed.ncbi.nlm.nih.gov/16564119" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16564119</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>10.</dt><dd><div class="bk_ref" id="LM505.REF.10">Feo
|
|
M, Eljarrat
|
|
E, Manaca
|
|
M, et al.
|
|
Pyrethroid use-malaria control and individual applications by households for other pests and home garden use.
|
|
Environ Int
|
|
2012;38:67-72.
|
|
[<a href="https://pubmed.ncbi.nlm.nih.gov/21982035" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21982035</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>11.</dt><dd><div class="bk_ref" id="LM505.REF.11">Corcellas
|
|
C, Feo
|
|
M, Torres
|
|
J, et al.
|
|
Pyrethroids in human breast milk: Occurrence and nursing daily intake estimation.
|
|
Environ Int
|
|
2012;47:17-22.
|
|
[<a href="https://pubmed.ncbi.nlm.nih.gov/22717642" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 22717642</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>12.</dt><dd><div class="bk_ref" id="LM505.REF.12">Pedersen
|
|
T, Smilowitz
|
|
J, Winter
|
|
C, et al.
|
|
Quantification of nonpersistent pesticides in small volumes of human breast milk with ultrahigh performance liquid chromatography coupled to tandem mass spectrometry.
|
|
J Agric Food Chem
|
|
2021;69:6676-89.
|
|
[<a href="/pmc/articles/PMC8422964/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC8422964</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/34098718" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 34098718</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>13.</dt><dd><div class="bk_ref" id="LM505.REF.13">Ito
|
|
S, Blajchman
|
|
A, Stephenson
|
|
M, et al.
|
|
Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication.
|
|
Am J Obstet Gynecol
|
|
1993;168:1393-9.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/8498418" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 8498418</span></a>]</div></dd></dl></dl></div></div><div id="LM505.Substance_Identification"><h2 id="_LM505_Substance_Identification_">Substance Identification</h2><div id="LM505.Substance_Name"><h3>Substance Name</h3><p>Permethrin</p></div><div id="LM505.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>52645-53-1</p></div><div id="LM505.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Anti-Infective Agents</p><p>Antiparasitic Agents</p><p>Insecticides</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK501383_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">December 15, 2024</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Permethrin. [Updated 2024 Dec 15].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/lactmed/LM211/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/lactmed/LM212/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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