326 lines
54 KiB
Text
326 lines
54 KiB
Text
<!DOCTYPE html>
|
|
<html xmlns="http://www.w3.org/1999/xhtml" xml:lang="en" class="no-js no-jr">
|
|
<head>
|
|
<!-- For pinger, set start time and add meta elements. -->
|
|
<script type="text/javascript">var ncbi_startTime = new Date();</script>
|
|
|
|
<!-- Logger begin -->
|
|
<meta name="ncbi_db" content="books">
|
|
<meta name="ncbi_pdid" content="book-part">
|
|
<meta name="ncbi_acc" content="NBK501345">
|
|
<meta name="ncbi_domain" content="lactmed">
|
|
<meta name="ncbi_report" content="reader">
|
|
<meta name="ncbi_type" content="fulltext">
|
|
<meta name="ncbi_objectid" content="">
|
|
<meta name="ncbi_pcid" content="/NBK501345/?report=reader">
|
|
<meta name="ncbi_pagename" content="Progesterone - Drugs and Lactation Database (LactMed®) - NCBI Bookshelf">
|
|
<meta name="ncbi_bookparttype" content="chapter">
|
|
<meta name="ncbi_app" content="bookshelf">
|
|
<!-- Logger end -->
|
|
|
|
<!--component id="Page" label="meta"/-->
|
|
<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Progesterone - Drugs and Lactation Database (LactMed®) - NCBI Bookshelf</title>
|
|
<meta charset="utf-8">
|
|
<meta name="apple-mobile-web-app-capable" content="no">
|
|
<meta name="viewport" content="initial-scale=1,minimum-scale=1,maximum-scale=1,user-scalable=no">
|
|
<meta name="jr-col-layout" content="auto">
|
|
<meta name="jr-prev-unit" content="/books/n/lactmed/LM227/?report=reader">
|
|
<meta name="jr-next-unit" content="/books/n/lactmed/LM228/?report=reader">
|
|
<meta name="bk-toc-url" content="/books/n/lactmed/?report=toc">
|
|
<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE">
|
|
<meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]">
|
|
<meta name="citation_title" content="Progesterone">
|
|
<meta name="citation_publisher" content="National Institute of Child Health and Human Development">
|
|
<meta name="citation_date" content="2024/10/15">
|
|
<meta name="citation_pmid" content="30000404">
|
|
<meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK501345/">
|
|
<meta name="citation_keywords" content="progesterone">
|
|
<meta name="citation_keywords" content="Agolutin">
|
|
<meta name="citation_keywords" content="Luteohormone">
|
|
<meta name="citation_keywords" content="Crinone">
|
|
<meta name="citation_keywords" content="Syngesterone">
|
|
<meta name="citation_keywords" content="Utrogestan">
|
|
<meta name="citation_keywords" content="Progestin">
|
|
<meta name="citation_keywords" content="Luteol">
|
|
<meta name="citation_keywords" content="Pregnenedione">
|
|
<meta name="citation_keywords" content="Progesteronum">
|
|
<meta name="citation_keywords" content="Glanducorpin">
|
|
<meta name="citation_keywords" content="Progesterol">
|
|
<meta name="citation_keywords" content="Gestormone">
|
|
<meta name="citation_keywords" content="Progestone">
|
|
<meta name="citation_keywords" content="Progestron">
|
|
<meta name="citation_keywords" content="Prometrium">
|
|
<meta name="citation_keywords" content="Cyclogest">
|
|
<meta name="citation_keywords" content="Corlutin">
|
|
<meta name="citation_keywords" content="Gestone">
|
|
<meta name="citation_keywords" content="Methylpregnone">
|
|
<meta name="citation_keywords" content="Hormoflaveine">
|
|
<meta name="citation_keywords" content="Progestasert">
|
|
<meta name="citation_keywords" content="Progestronol">
|
|
<meta name="citation_keywords" content="Lutociclina">
|
|
<meta name="citation_keywords" content="Progestosol">
|
|
<meta name="citation_keywords" content="Syngestrets">
|
|
<meta name="citation_keywords" content="Flavolutan">
|
|
<meta name="citation_keywords" content="Gynolutone">
|
|
<meta name="citation_keywords" content="Hormoluton">
|
|
<meta name="citation_keywords" content="Lingusorbs">
|
|
<meta name="citation_keywords" content="Lutocyclin">
|
|
<meta name="citation_keywords" content="Membrettes">
|
|
<meta name="citation_keywords" content="Protormone">
|
|
<meta name="citation_keywords" content="Syntolutan">
|
|
<meta name="citation_keywords" content="Corlutina">
|
|
<meta name="citation_keywords" content="Corluvite">
|
|
<meta name="citation_keywords" content="Fologenon">
|
|
<meta name="citation_keywords" content="Lucorteum">
|
|
<meta name="citation_keywords" content="Luteostab">
|
|
<meta name="citation_keywords" content="Lutocylin">
|
|
<meta name="citation_keywords" content="Lutromone">
|
|
<meta name="citation_keywords" content="Corporin">
|
|
<meta name="citation_keywords" content="Gesterol">
|
|
<meta name="citation_keywords" content="Gynlutin">
|
|
<meta name="citation_keywords" content="Luteodyn">
|
|
<meta name="citation_keywords" content="Luteogan">
|
|
<meta name="citation_keywords" content="Luteopur">
|
|
<meta name="citation_keywords" content="Luteosan">
|
|
<meta name="citation_keywords" content="Luteovis">
|
|
<meta name="citation_keywords" content="Lutoform">
|
|
<meta name="citation_keywords" content="Nalutron">
|
|
<meta name="citation_keywords" content="Piaponon">
|
|
<meta name="citation_keywords" content="Primolut">
|
|
<meta name="citation_keywords" content="Progekan">
|
|
<meta name="citation_keywords" content="Prolidon">
|
|
<meta name="citation_keywords" content="Proluton">
|
|
<meta name="citation_keywords" content="Gestron">
|
|
<meta name="citation_keywords" content="Lutidon">
|
|
<meta name="citation_keywords" content="Lutogyl">
|
|
<meta name="citation_keywords" content="Prolets">
|
|
<meta name="citation_keywords" content="Lutren">
|
|
<meta name="citation_keywords" content="Lutex">
|
|
<meta name="citation_keywords" content="Luteal hormone">
|
|
<meta name="citation_keywords" content="Luteinique">
|
|
<meta name="citation_keywords" content="Prochieve">
|
|
<meta name="citation_keywords" content="Prolutone">
|
|
<meta name="citation_keywords" content="Lucorteum Sol">
|
|
<meta name="citation_keywords" content="Lutocyclin M">
|
|
<meta name="citation_keywords" content="Bio-luton">
|
|
<meta name="citation_keywords" content="Lutin">
|
|
<meta name="citation_keywords" content="Lipo-Lutin">
|
|
<meta name="citation_keywords" content="Projestaject">
|
|
<meta name="citation_keywords" content="Gynoluton">
|
|
<meta name="citation_keywords" content="Luteocrin normale">
|
|
<meta name="citation_keywords" content="Corpus luteum hormone">
|
|
<meta name="citation_keywords" content="Cyclogesterin">
|
|
<meta name="citation_keywords" content="Synovex S">
|
|
<meta name="citation_keywords" content="Gesterol 50">
|
|
<meta name="citation_keywords" content="Endometrin">
|
|
<meta name="citation_keywords" content="Gesterol 100">
|
|
<meta name="citation_keywords" content="Percutacrine Luteinique">
|
|
<meta name="citation_keywords" content="Progesterona">
|
|
<meta name="citation_keywords" content="Luteol (VAN)">
|
|
<meta name="citation_keywords" content="Crinone progesterone gel">
|
|
<meta name="citation_keywords" content="CCRIS 533">
|
|
<meta name="citation_keywords" content="UNII-4G7DS2Q64Y">
|
|
<meta name="citation_keywords" content="(8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one">
|
|
<link rel="schema.DC" href="http://purl.org/DC/elements/1.0/">
|
|
<meta name="DC.Title" content="Progesterone">
|
|
<meta name="DC.Type" content="Text">
|
|
<meta name="DC.Publisher" content="National Institute of Child Health and Human Development">
|
|
<meta name="DC.Date" content="2024/10/15">
|
|
<meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK501345/">
|
|
<meta name="description" content="Because of the low reported levels of progesterone in breastmilk, even with the high-dose products, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants. The progesterone vaginal ring available in some countries produces maternal blood levels that are lower than those of ovulating women.[1] Most studies indicate that progesterone is not detrimental to milk production or duration of nursing.[2,3] No special precautions appear to be required.">
|
|
<meta name="og:title" content="Progesterone">
|
|
<meta name="og:type" content="book">
|
|
<meta name="og:description" content="Because of the low reported levels of progesterone in breastmilk, even with the high-dose products, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants. The progesterone vaginal ring available in some countries produces maternal blood levels that are lower than those of ovulating women.[1] Most studies indicate that progesterone is not detrimental to milk production or duration of nursing.[2,3] No special precautions appear to be required.">
|
|
<meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK501345/">
|
|
<meta name="og:site_name" content="NCBI Bookshelf">
|
|
<meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-lactmed-lrg.png">
|
|
<meta name="twitter:card" content="summary">
|
|
<meta name="twitter:site" content="@ncbibooks">
|
|
<meta name="bk-non-canon-loc" content="/books/n/lactmed/LM470/?report=reader">
|
|
<link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK501345/">
|
|
<link href="https://fonts.googleapis.com/css?family=Archivo+Narrow:400,700,400italic,700italic&subset=latin" rel="stylesheet" type="text/css">
|
|
<link rel="stylesheet" href="/corehtml/pmc/jatsreader/ptpmc_3.22/css/libs.min.css">
|
|
<link rel="stylesheet" href="/corehtml/pmc/jatsreader/ptpmc_3.22/css/jr.min.css">
|
|
<meta name="format-detection" content="telephone=no">
|
|
<link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css">
|
|
<link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css//books_print.min.css" type="text/css" media="print">
|
|
<link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_reader.min.css" type="text/css">
|
|
<style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} .body-content h2, .body-content .h2 {border-bottom: 1px solid #97B0C8} .body-content h2.inline {border-bottom: none} a.page-toc-label , .jig-ncbismoothscroll a {text-decoration:none;border:0 !important} .temp-labeled-list .graphic {display:inline-block !important} .temp-labeled-list img{width:100%}</style>
|
|
|
|
<link rel="shortcut icon" href="//www.ncbi.nlm.nih.gov/favicon.ico">
|
|
<meta name="ncbi_phid" content="CE8B42F17D836BC100000000002A0024.m_5">
|
|
<meta name='referrer' content='origin-when-cross-origin'/><link type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4216699/css/3852956/3849091.css"></head>
|
|
<body>
|
|
<!-- Book content! -->
|
|
|
|
|
|
<div id="jr" data-jr-path="/corehtml/pmc/jatsreader/ptpmc_3.22/"><div class="jr-unsupported"><table class="modal"><tr><td><span class="attn inline-block"></span><br />Your browser does not support the NLM PubReader view.<br />Go to <a href="/pmc/about/pr-browsers/">this page</a> to see a list of supported browsers<br />or return to the <br /><a href="/books/NBK501345/?report=classic">regular view</a>.</td></tr></table></div><div id="jr-ui" class="hidden"><nav id="jr-head"><div class="flexh tb"><div id="jr-tb1"><a id="jr-links-sw" class="hidden" title="Links"><svg xmlns="http://www.w3.org/2000/svg" version="1.1" x="0px" y="0px" viewBox="0 0 70.6 85.3" style="enable-background:new 0 0 70.6 85.3;vertical-align:middle" xml:space="preserve" width="24" height="24">
|
|
<style type="text/css">.st0{fill:#939598;}</style>
|
|
<g>
|
|
<path class="st0" d="M36,0C12.8,2.2-22.4,14.6,19.6,32.5C40.7,41.4-30.6,14,35.9,9.8"></path>
|
|
<path class="st0" d="M34.5,85.3c23.2-2.2,58.4-14.6,16.4-32.5c-21.1-8.9,50.2,18.5-16.3,22.7"></path>
|
|
<path class="st0" d="M34.7,37.1c66.5-4.2-4.8-31.6,16.3-22.7c42.1,17.9,6.9,30.3-16.4,32.5h1.7c-66.2,4.4,4.8,31.6-16.3,22.7 c-42.1-17.9-6.9-30.3,16.4-32.5"></path>
|
|
</g>
|
|
</svg> Books</a></div><div class="jr-rhead f1 flexh"><div class="head"><a href="/books/n/lactmed/LM227/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="body"><div class="t">Progesterone</div><div class="j">Drugs and Lactation Database (LactMed®) [Internet]</div></div><div class="tail"><a href="/books/n/lactmed/LM228/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></div><div id="jr-tb2"><a id="jr-bkhelp-sw" class="btn wsprkl hidden" title="Help with NLM PubReader">?</a><a id="jr-help-sw" class="btn wsprkl hidden" title="Settings and typography in NLM PubReader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512" preserveAspectRatio="none"><path d="M462,283.742v-55.485l-29.981-10.662c-11.431-4.065-20.628-12.794-25.274-24.001 c-0.002-0.004-0.004-0.009-0.006-0.013c-4.659-11.235-4.333-23.918,0.889-34.903l13.653-28.724l-39.234-39.234l-28.72,13.652 c-10.979,5.219-23.68,5.546-34.908,0.889c-0.005-0.002-0.01-0.003-0.014-0.005c-11.215-4.65-19.933-13.834-24-25.273L283.741,50 h-55.484l-10.662,29.981c-4.065,11.431-12.794,20.627-24.001,25.274c-0.005,0.002-0.009,0.004-0.014,0.005 c-11.235,4.66-23.919,4.333-34.905-0.889l-28.723-13.653l-39.234,39.234l13.653,28.721c5.219,10.979,5.545,23.681,0.889,34.91 c-0.002,0.004-0.004,0.009-0.006,0.013c-4.649,11.214-13.834,19.931-25.271,23.998L50,228.257v55.485l29.98,10.661 c11.431,4.065,20.627,12.794,25.274,24c0.002,0.005,0.003,0.01,0.005,0.014c4.66,11.236,4.334,23.921-0.888,34.906l-13.654,28.723 l39.234,39.234l28.721-13.652c10.979-5.219,23.681-5.546,34.909-0.889c0.005,0.002,0.01,0.004,0.014,0.006 c11.214,4.649,19.93,13.833,23.998,25.271L228.257,462h55.484l10.595-29.79c4.103-11.538,12.908-20.824,24.216-25.525 c0.005-0.002,0.009-0.004,0.014-0.006c11.127-4.628,23.694-4.311,34.578,0.863l28.902,13.738l39.234-39.234l-13.66-28.737 c-5.214-10.969-5.539-23.659-0.886-34.877c0.002-0.005,0.004-0.009,0.006-0.014c4.654-11.225,13.848-19.949,25.297-24.021 L462,283.742z M256,331.546c-41.724,0-75.548-33.823-75.548-75.546s33.824-75.547,75.548-75.547 c41.723,0,75.546,33.824,75.546,75.547S297.723,331.546,256,331.546z"></path></svg></a><a id="jr-fip-sw" class="btn wsprkl hidden" title="Find"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 550 600" preserveAspectRatio="none"><path fill="none" stroke="#000" stroke-width="36" stroke-linecap="round" style="fill:#FFF" d="m320,350a153,153 0 1,0-2,2l170,170m-91-117 110,110-26,26-110-110"></path></svg></a><a id="jr-rtoc-sw" class="btn wsprkl hidden" title="Table of Contents"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M20,20h10v8H20V20zM36,20h44v8H36V20zM20,37.33h10v8H20V37.33zM36,37.33h44v8H36V37.33zM20,54.66h10v8H20V54.66zM36,54.66h44v8H36V54.66zM20,72h10v8 H20V72zM36,72h44v8H36V72z"></path></svg></a></div></div></nav><nav id="jr-dash" class="noselect"><nav id="jr-dash" class="noselect"><div id="jr-pi" class="hidden"><a id="jr-pi-prev" class="hidden" title="Previous page"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a><div class="pginfo">Page <i class="jr-pg-pn">0</i> of <i class="jr-pg-lp">0</i></div><a id="jr-pi-next" class="hidden" title="Next page"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div><div id="jr-is-tb"><a id="jr-is-sw" class="btn wsprkl hidden" title="Switch between Figures/Tables strip and Progress bar"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><rect x="10" y="40" width="20" height="20"></rect><rect x="40" y="40" width="20" height="20"></rect><rect x="70" y="40" width="20" height="20"></rect></svg></a></div><nav id="jr-istrip" class="istrip hidden"><a id="jr-is-prev" href="#" class="hidden" title="Previous"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M80,40 60,65 80,90 70,90 50,65 70,40z M50,40 30,65 50,90 40,90 20,65 40,40z"></path><text x="35" y="25" textLength="60" style="font-size:25px">Prev</text></svg></a><a id="jr-is-next" href="#" class="hidden" title="Next"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M20,40 40,65 20,90 30,90 50,65 30,40z M50,40 70,65 50,90 60,90 80,65 60,40z"></path><text x="15" y="25" textLength="60" style="font-size:25px">Next</text></svg></a></nav><nav id="jr-progress"></nav></nav></nav><aside id="jr-links-p" class="hidden flexv"><div class="tb sk-htbar flexh"><div><a class="jr-p-close btn wsprkl">Done</a></div><div class="title-text f1">NCBI Bookshelf</div></div><div class="cnt lol f1"><a href="/books/">Home</a><a href="/books/browse/">Browse All Titles</a><a class="btn share" target="_blank" rel="noopener noreferrer" href="https://www.facebook.com/sharer/sharer.php?u=https://www.ncbi.nlm.nih.gov/books/NBK501345/"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 33 33" style="vertical-align:middle" width="24" height="24" preserveAspectRatio="none"><g><path d="M 17.996,32L 12,32 L 12,16 l-4,0 l0-5.514 l 4-0.002l-0.006-3.248C 11.993,2.737, 13.213,0, 18.512,0l 4.412,0 l0,5.515 l-2.757,0 c-2.063,0-2.163,0.77-2.163,2.209l-0.008,2.76l 4.959,0 l-0.585,5.514L 18,16L 17.996,32z"></path></g></svg> Share on Facebook</a><a class="btn share" target="_blank" rel="noopener noreferrer" href="https://twitter.com/intent/tweet?url=https://www.ncbi.nlm.nih.gov/books/NBK501345/&text=Progesterone"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 33 33" style="vertical-align:middle" width="24" height="24"><g><path d="M 32,6.076c-1.177,0.522-2.443,0.875-3.771,1.034c 1.355-0.813, 2.396-2.099, 2.887-3.632 c-1.269,0.752-2.674,1.299-4.169,1.593c-1.198-1.276-2.904-2.073-4.792-2.073c-3.626,0-6.565,2.939-6.565,6.565 c0,0.515, 0.058,1.016, 0.17,1.496c-5.456-0.274-10.294-2.888-13.532-6.86c-0.565,0.97-0.889,2.097-0.889,3.301 c0,2.278, 1.159,4.287, 2.921,5.465c-1.076-0.034-2.088-0.329-2.974-0.821c-0.001,0.027-0.001,0.055-0.001,0.083 c0,3.181, 2.263,5.834, 5.266,6.438c-0.551,0.15-1.131,0.23-1.73,0.23c-0.423,0-0.834-0.041-1.235-0.118 c 0.836,2.608, 3.26,4.506, 6.133,4.559c-2.247,1.761-5.078,2.81-8.154,2.81c-0.53,0-1.052-0.031-1.566-0.092 c 2.905,1.863, 6.356,2.95, 10.064,2.95c 12.076,0, 18.679-10.004, 18.679-18.68c0-0.285-0.006-0.568-0.019-0.849 C 30.007,8.548, 31.12,7.392, 32,6.076z"></path></g></svg> Share on Twitter</a></div></aside><aside id="jr-rtoc-p" class="hidden flexv"><div class="tb sk-htbar flexh"><div><a class="jr-p-close btn wsprkl">Done</a></div><div class="title-text f1">Table of Content</div></div><div class="cnt lol f1"><a href="/books/n/lactmed/?report=reader">Title Information</a><a href="/books/n/lactmed/toc/?report=reader">Table of Contents Page</a></div></aside><aside id="jr-help-p" class="hidden flexv"><div class="tb sk-htbar flexh"><div><a class="jr-p-close btn wsprkl">Done</a></div><div class="title-text f1">Settings</div></div><div class="cnt f1"><div id="jr-typo-p" class="typo"><div><a class="sf btn wsprkl">A-</a><a class="lf btn wsprkl">A+</a></div><div><a class="bcol-auto btn wsprkl"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 200 100" preserveAspectRatio="none"><text x="10" y="70" style="font-size:60px;font-family: Trebuchet MS, ArialMT, Arial, sans-serif" textLength="180">AUTO</text></svg></a><a class="bcol-1 btn wsprkl"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M15,25 85,25zM15,40 85,40zM15,55 85,55zM15,70 85,70z"></path></svg></a><a class="bcol-2 btn wsprkl"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M5,25 45,25z M55,25 95,25zM5,40 45,40z M55,40 95,40zM5,55 45,55z M55,55 95,55zM5,70 45,70z M55,70 95,70z"></path></svg></a></div></div><div class="lol"><a class="" href="/books/NBK501345/?report=classic">Switch to classic view</a><a href="/books/NBK501345/pdf/Bookshelf_NBK501345.pdf">PDF (138K)</a><a href="/books/NBK501345/?report=printable">Print View</a></div></div></aside><aside id="jr-bkhelp-p" class="hidden flexv"><div class="tb sk-htbar flexh"><div><a class="jr-p-close btn wsprkl">Done</a></div><div class="title-text f1">Help</div></div><div class="cnt f1 lol"><a id="jr-helpobj-sw" data-path="/corehtml/pmc/jatsreader/ptpmc_3.22/" data-href="/corehtml/pmc/jatsreader/ptpmc_3.22/img/bookshelf/help.xml" href="">Help</a><a href="mailto:info@ncbi.nlm.nih.gov?subject=PubReader%20feedback%20%2F%20NBK501345%20%2F%20sid%3ACE8B5AF87C7FFCB1_0191SID%20%2F%20phid%3ACE8B42F17D836BC100000000002A0024.4">Send us feedback</a><a id="jr-about-sw" data-path="/corehtml/pmc/jatsreader/ptpmc_3.22/" data-href="/corehtml/pmc/jatsreader/ptpmc_3.22/img/bookshelf/about.xml" href="">About PubReader</a></div></aside><aside id="jr-objectbox" class="thidden hidden"><div class="jr-objectbox-close wsprkl">✘</div><div class="jr-objectbox-inner cnt"><div class="jr-objectbox-drawer"></div></div></aside><nav id="jr-pm-left" class="hidden"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 40 800" preserveAspectRatio="none"><text font-stretch="ultra-condensed" x="800" y="-15" text-anchor="end" transform="rotate(90)" font-size="18" letter-spacing=".1em">Previous Page</text></svg></nav><nav id="jr-pm-right" class="hidden"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 40 800" preserveAspectRatio="none"><text font-stretch="ultra-condensed" x="800" y="-15" text-anchor="end" transform="rotate(90)" font-size="18" letter-spacing=".1em">Next Page</text></svg></nav><nav id="jr-fip" class="hidden"><nav id="jr-fip-term-p"><input type="search" placeholder="search this page" id="jr-fip-term" autocorrect="off" autocomplete="off" /><a id="jr-fip-mg" class="wsprkl btn" title="Find"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 550 600" preserveAspectRatio="none"><path fill="none" stroke="#000" stroke-width="36" stroke-linecap="round" style="fill:#FFF" d="m320,350a153,153 0 1,0-2,2l170,170m-91-117 110,110-26,26-110-110"></path></svg></a><a id="jr-fip-done" class="wsprkl btn" title="Dismiss find">✘</a></nav><nav id="jr-fip-info-p"><a id="jr-fip-prev" class="wsprkl btn" title="Jump to previuos match">◀</a><button id="jr-fip-matches">no matches yet</button><a id="jr-fip-next" class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK501345_"><span class="title" itemprop="name">Progesterone</span></h1><p class="fm-aai"><a href="#_NBK501345_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 10 minutes</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><p>CASRN: 57-83-0</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134971194" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134971194" alt="image 134971194 in the ncbi pubchem database" /></a><div id="LM470.Drug_Levels_and_Effects"><h2 id="_LM470_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM470.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Because of the low reported levels of progesterone in breastmilk, even with the high-dose products, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants. The progesterone vaginal ring available in some countries produces maternal blood levels that are lower than those of ovulating women.[<a class="bibr" href="#LM470.REF.1" rid="LM470.REF.1">1</a>] Most studies indicate that progesterone is not detrimental to milk production or duration of nursing.[<a class="bibr" href="#LM470.REF.2" rid="LM470.REF.2">2</a>,<a class="bibr" href="#LM470.REF.3" rid="LM470.REF.3">3</a>] No special precautions appear to be required.</p><p>In Russia, a progesterone gel (Progestogel - Besins Healthcare; not available in the US) has been used topically as a one-time application to the breasts to treat postpartum breast engorgement when more conservative measures have failed.[<a class="bibr" href="#LM470.REF.4" rid="LM470.REF.4">4</a>] A subsequent study failed to detect any decrease in breast hardness 20 minutes after application of progesterone gel in mothers with engorgement.[<a class="bibr" href="#LM470.REF.5" rid="LM470.REF.5">5</a>] The safety and efficacy of this use have not been well studied and the manufacturer of Progestogel recommends avoiding its use during lactation.</p></div><div id="LM470.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Women who received 6 subdermal implants containing 100 mg each of progesterone between days 30 to 35 postpartum for contraception had milk progesterone levels measured. Milk progesterone levels were 5.7 mcg/L in 6 women at 3 to 4 months postpartum and 6.3 mcg/L in 7 women at 9 to 12 months postpartum. By comparison, 9 women who received a Copper T intrauterine device had negligible progesterone levels. The authors estimated that infants would receive about 5 mcg of progesterone daily through breastmilk.[<a class="bibr" href="#LM470.REF.6" rid="LM470.REF.6">6</a>,<a class="bibr" href="#LM470.REF.7" rid="LM470.REF.7">7</a>]</p><p><i>Infant Levels.</i> Women received 6 subdermal implants containing 100 mg each of progesterone between days 30 to 35 postpartum for contraception. A metabolite of progesterone, pregnane-3-glucuronide, was measured in the urine of their infants. At 3 to 4 months (n = 9) and 9 to 12 months (n = 7) postpartum, urine metabolite levels were 6.3 mcg/L and 15.7 mcg/L, respectively. These values were not significantly different from those of infants whose mothers were using a Copper T intrauterine device.[<a class="bibr" href="#LM470.REF.6" rid="LM470.REF.6">6</a>,<a class="bibr" href="#LM470.REF.7" rid="LM470.REF.7">7</a>]</p></div><div id="LM470.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Eighty-four women had 6 subdermal implants containing 100 mg each of progesterone inserted between days 30 to 35 postpartum as a contraceptive. Compared to women who received either a placebo or a Copper T intrauterine device, there were no differences in the growth rates of their infants over the first 6 months postpartum.[<a class="bibr" href="#LM470.REF.8" rid="LM470.REF.8">8</a>]</p><p>One hundred ninety-two mothers who received 6 subdermal implants containing 100 mg each of progesterone inserted on postpartum day 60 as a contraceptive. The weight gain of 60 infants who were exclusively breastfed for 6 months was compared to that of infants whose mothers received either placebo (n = 68 at day 30) or a Copper T (n = 64 at day 30 and n = 49 at day 60) intrauterine device. No differences were found in the average weight gains among the 3 groups of infants at 6 months of age.[<a class="bibr" href="#LM470.REF.9" rid="LM470.REF.9">9</a>]</p><p>Vaginal rings that released progesterone were inserted at about 60 days postpartum in 128 women. The 2 types of rings released progesterone either 7.5 mg daily decreasing to 4.5 mg at 90 days or 15 mg daily decreasing to 7 mg daily at 90 days. Over the first 12 months postpartum, no differences in weight gain were found between the exclusively breastfed infants of mothers who received the progesterone rings and control mothers who received a Copper T intrauterine device for contraception.[<a class="bibr" href="#LM470.REF.10" rid="LM470.REF.10">10</a>]</p><p>One hundred twenty breastfeeding women used a vaginal ring that released about 10 mg daily of progesterone for 90 days, starting during weeks 5 to 7 postpartum. No differences were found in the growth of breastfed infants or in developmental milestones compared to the normal population values.[<a class="bibr" href="#LM470.REF.11" rid="LM470.REF.11">11</a>]</p><p>One hundred eighty-seven breastfeeding women used a vaginal ring that released about 10 mg daily of progesterone, starting at about day 57 postpartum. No differences were found in weight gain during the first 6 months of use compared to infants whose mothers received either a Copper T intrauterine device, an oral progestin-only contraceptive or levonorgestrel implant.[<a class="bibr" href="#LM470.REF.12" rid="LM470.REF.12">12</a>]</p><p>A study comparing 100 women who received vaginal ring that released about 10 mg daily of progesterone to those who received a Copper T intrauterine device between days 29 and 64 postpartum found no differences in weight gain of their breastfed infants over the first year postpartum.[<a class="bibr" href="#LM470.REF.13" rid="LM470.REF.13">13</a>]</p><p>Two hundred eighty-five women who received a vaginal ring that released about 10 mg daily of progesterone were compared to 262 women who received a Copper T intrauterine device beginning between weeks 5 and 9 postpartum. No differences in the weight gain of breastfed infants were seen between the 2 groups during the 14-month observation period.[<a class="bibr" href="#LM470.REF.14" rid="LM470.REF.14">14</a>]</p><p>A study comparing progesterone ring (n = 459) to the copper-T IUD (n = 330) in postpartum women found no adverse effects on infant breastfeeding or growth.[<a class="bibr" href="#LM470.REF.15" rid="LM470.REF.15">15</a>]</p></div><div id="LM470.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Eighty-four women had 6 subdermal implants containing 100 mg each of progesterone inserted between days 30 to 35 postpartum as a contraceptive. Compared to women who received either a placebo or a Copper T intrauterine device, no difference was found in the breastfeeding rates during the first 9 months postpartum. At 1 year postpartum, more women in the Copper T group were breastfeeding than in the progesterone or placebo groups.[<a class="bibr" href="#LM470.REF.8" rid="LM470.REF.8">8</a>]</p><p>Vaginal rings that released progesterone were inserted at about 60 days postpartum in 246 women. The 3 types of rings released progesterone either 5, 10 or 15 mg daily. Control women received a Copper T intrauterine device. At 6 and 12 months postpartum there was no significant difference in the percentage of infants who were breastfed between the progesterone and Copper T groups.[<a class="bibr" href="#LM470.REF.16" rid="LM470.REF.16">16</a>]</p><p>One hundred twenty breastfeeding women used a vaginal ring that released about 10 mg daily of progesterone, starting during weeks 5 to 7 postpartum. The rate of weaning was greater in the progesterone ring group than in groups of women who received levonorgestrel or norethindrone implants for postpartum contraception.[<a class="bibr" href="#LM470.REF.11" rid="LM470.REF.11">11</a>]</p><p>In a multicenter study, 802 women who received a vaginal ring that released about 10 mg daily of progesterone were compared to 734 women who received a Copper T intrauterine device beginning at day 29 to 63 postpartum. No differences were found in the rate of breastfeeding between the 2 groups over the first year postpartum.[<a class="bibr" href="#LM470.REF.17" rid="LM470.REF.17">17</a>]</p><p>Two hundred eighty-five women who received a vaginal ring that released about 10 mg daily of progesterone were compared to 262 women who received a Copper T intrauterine device beginning between weeks 5 and 9 postpartum. No differences in the breastfeeding rates were seen between the 2 groups during the 14-month observation period.[<a class="bibr" href="#LM470.REF.14" rid="LM470.REF.14">14</a>]</p><p>An observational study followed 192 women who used a vaginal ring that released 10 mg of progesterone daily beginning between days 54 and 64 postpartum. All subjects used the vaginal ring for at least 4 months; 90% were still using it at 6 months and 73% were using it at 9 months postpartum. The duration of breastfeeding and infant growth were similar to reference groups.[<a class="bibr" href="#LM470.REF.18" rid="LM470.REF.18">18</a>]</p><p>A double-blind placebo-controlled trial randomized 46 postpartum women who were abstinent former smokers to oral micronized progesterone 200 mg twice a day or placebo for 4 weeks to assess smoking abstinence rates. Entry into the study occurred only after breastfeeding was well established. No statistical difference was found in the number of days of breastfeeding between the groups.[<a class="bibr" href="#LM470.REF.19" rid="LM470.REF.19">19</a>]</p><p>A study comparing progesterone ring (n = 459) to the copper-T IUD (n = 330) in postpartum women found that lactation amenorrhea lasted longer (405 days) with the progesterone ring than with the IUD (120 days).[<a class="bibr" href="#LM470.REF.15" rid="LM470.REF.15">15</a>]</p><p>A transgender woman took and spironolactone 50 mg twice daily to suppress testosterone, domperidone 10 mg three times daily, increasing to 20 mg four times daily, oral micronized progesterone 200 mg daily and oral estradiol to 8 mg daily and pumped her breasts 6 times daily to induce lactation. After 3 months of treatment, estradiol regimen was changed to a 0.025 mg daily patch and the progesterone dose was lowered to 100 mg daily. Two weeks later, she began exclusively breastfeeding the newborn of her partner. Breastfeeding was exclusive for 6 weeks, during which the infant's growth, development and bowel habits were normal. The patient continued to partially breastfeed the infant for at least 6 months.[<a class="bibr" href="#LM470.REF.20" rid="LM470.REF.20">20</a>]</p><p>A transgender woman was taking spironolactone 100 mg twice daily, progesterone 200 mg daily and estradiol 5 mg daily. She was started on domperidone 10 mg three times daily to increase milk supply. She was able to pump 3 to 5 ounces of milk daily one month after starting. The dose of domperidone was increased to 30 mg three times daily after 8 weeks because of a decreased milk supply. Her milk supply returned to 3 to 5 ounces of milk daily. By 6 months, her milk supply had decreased to about 5 mL daily, even though her serum prolactin was still elevated.[<a class="bibr" href="#LM470.REF.21" rid="LM470.REF.21">21</a>]</p><p>A transgender woman had been taking estradiol 2 mg twice daily for 14 years. She began taking domperidone 10 mg four times daily and progesterone 100 mg daily 107 days prior to her partner’s due date. At the same time, the estradiol dosage was increased to 4 mg twice daily. At 94 days prior to the due date, the domperidone dosage was increased to 20 mg four times daily, the progesterone dose was increased to 200 mg daily and estrogen was changed to transdermal estradiol 25 mcg daily. Progesterone was discontinued 34 days prior to the due date. She pumped and stored milk beginning at 34 days prior to the due date and by 27 days postpartum, she was breastfeeding the infant twice daily, expressing 150 mL of milk daily and was able to decrease the domperidone dosage to 20 mg three times daily. Lower dosages reduced milk supply.[<a class="bibr" href="#LM470.REF.22" rid="LM470.REF.22">22</a>]</p><p>A transgender woman was taking sublingual estradiol 4 mg twice daily, spironolactone 100 mg twice daily and progesterone 200 mg at bedtime for gender-affirming therapy. In order to prepare for the birth of the infant being carried by her partner, sublingual estradiol was increased to 6 mg twice daily and progesterone was increased to 400 mg at bedtime. Domperidone 10 mg twice daily was also started to increase serum prolactin levels and later increased to 20 mg 4 times daily. Before the delivery date, progesterone was stopped, spironolactone was decreased to 100 mg daily and estradiol was changed to 25 mcg per day transdermally. At day 59 postpartum, estradiol was changed to 2 mg per day sublingually and spironolactone was increased to 100 mg twice daily. The patient was able to produce up to 240 mL of milk daily containing typical macronutrient and oligosaccharide levels.[<a class="bibr" href="#LM470.REF.23" rid="LM470.REF.23">23</a>]</p><p>A transgender woman who wished to breastfeed was given estradiol transdermal patch 150 mcg daily and progesterone 100 mg daily by mouth. Later estradiol spray 100 mcg and domperidone 10 mg 4 times daily were added. Domperidone dosage was then doubled to 20 mg 4 times daily and progesterone was doubled to 100 mg twice daily. After further adjustment of estradiol and progesterone dosages, 7 mL of milk was produced with pumping, but 2 weeks after the infant’s birth, lactation induction was discontinued at the patient’s request.[<a class="bibr" href="#LM470.REF.24" rid="LM470.REF.24">24</a>]</p><p>A 50-year-old transgender woman wished to breastfeed her grandchild was taking baseline treatment with estradiol 0.3 mg transdermal patch every 72 hours and micronized progesterone 200 mg oral once daily. To initiate lactation, her estradiol dose was increased to a 0.4 mg transdermal patch every 72 hours and nipple stimulation was initiated. Later the patient’s progesterone was increased to 300 mg daily and metoclopramide oral 10 mg three times daily was initiated. She lactated for a total of two weeks and nursed the four-month-old infant on multiple occasions. Her peak milk production was 30 mL from her larger right breast, and 8 mL from her smaller left breast.[<a class="bibr" href="#LM470.REF.25" rid="LM470.REF.25">25</a>]</p><p>A 50-year-old transgender woman wished to breastfeed the expected infant of her partner. She was given progesterone in dosages increasing from 100 mg to 500 mg daily along with estradiol and domperidone to stimulate lactation. Progesterone was discontinued after 123 days of treatment. The patient was able to produce small quantities of milk and was able to directly breastfeed the infant.[<a class="bibr" href="#LM470.REF.26" rid="LM470.REF.26">26</a>]</p></div><div id="LM470.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p>(Contraception) <a href="/books/n/lactmed/LM622/?report=reader">Etonogestrel</a>, <a href="/books/n/lactmed/LM1089/?report=reader">Intrauterine Copper Contraceptive</a>, <a href="/books/n/lactmed/LM1336/?report=reader">Levonorgestrel Implant</a>, <a href="/books/n/lactmed/LM1335/?report=reader">Intrauterine Levonorgestrel</a>, <a href="/books/n/lactmed/LM415/?report=reader">Medroxyprogesterone Acetate</a></p></div><div id="LM470.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="LM470.REF.1">RamaRao S, Clark H, Merkatz R, et al. Progesterone vaginal ring: Introducing a contraceptive to meet the needs of breastfeeding women.
|
|
Contraception
|
|
2013;88:591-8.
|
|
[<a href="https://pubmed.ncbi.nlm.nih.gov/23769015" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 23769015</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="LM470.REF.2">Carr
|
|
SL, Gaffield
|
|
ME, Dragoman
|
|
MV, et al.
|
|
Safety of the progesterone-releasing vaginal ring (PVR) among lactating women: A systematic review.
|
|
Contraception
|
|
2016;94:253-61.
|
|
[<a href="https://pubmed.ncbi.nlm.nih.gov/25869631" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25869631</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="LM470.REF.3">Phillips
|
|
SJ, Tepper
|
|
NK, Kapp
|
|
N, et al.
|
|
Progestogen-only contraceptive use among breastfeeding women: A systematic review.
|
|
Contraception
|
|
2016;94:226-52.
|
|
[<a href="/pmc/articles/PMC11376434/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC11376434</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/26410174" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26410174</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>4.</dt><dd><div class="bk_ref" id="LM470.REF.4">Pustotina
|
|
O.
|
|
Management of mastitis and breast engorgement in breastfeeding women.
|
|
J Matern Fetal Neonatal Med
|
|
2016;29:3121-5.
|
|
[<a href="https://pubmed.ncbi.nlm.nih.gov/26513602" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26513602</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>5.</dt><dd><div class="bk_ref" id="LM470.REF.5">Alekseev
|
|
NP. Progesterone-containing gel does not eliminate postpartum breast engorgement?
|
|
Breastfeed Med
|
|
2017;12:122-3.
|
|
[<a href="https://pubmed.ncbi.nlm.nih.gov/28170298" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28170298</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>6.</dt><dd><div class="bk_ref" id="LM470.REF.6">Croxatto
|
|
HB, Díaz
|
|
S. The place of progesterone in human contraception.
|
|
J Steroid Biochem
|
|
1987;27:991-4.
|
|
[<a href="https://pubmed.ncbi.nlm.nih.gov/3320572" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 3320572</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>7.</dt><dd><div class="bk_ref" id="LM470.REF.7">Croxatto HB, Díaz S, Peralta O, et al. Subdermal progesterone implants for fertility regulation in nursing women. In: Zatuchni G, Goldsmith A, Shelton J, et al., eds. Long-acting contraceptive delivery systems. Philadelphia: Harper & Row; 1984:543-9.</div></dd></dl><dl class="bkr_refwrap"><dt>8.</dt><dd><div class="bk_ref" id="LM470.REF.8">Croxatto
|
|
HB, Díaz
|
|
S, Peralta
|
|
O, et al.
|
|
Fertility regulation in nursing women. II. Comparative performance of progesterone implants versus placebo and copper T.
|
|
Am J Obstet Gynecol
|
|
1982;144:201-8.
|
|
[<a href="https://pubmed.ncbi.nlm.nih.gov/7114130" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 7114130</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>9.</dt><dd><div class="bk_ref" id="LM470.REF.9">Díaz
|
|
S, Peralta
|
|
O, Juez
|
|
G, et al.
|
|
Fertility regulation in nursing women. VI. Contraceptive effectiveness of a subdermal progesterone implant.
|
|
Contraception
|
|
1984;30:311-25.
|
|
[<a href="https://pubmed.ncbi.nlm.nih.gov/6509984" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 6509984</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>10.</dt><dd><div class="bk_ref" id="LM470.REF.10">Díaz
|
|
S, Jackanicz
|
|
TM, Herreros
|
|
C, et al.
|
|
Fertility regulation in nursing women: VIII. Progesterone plasma levels and contraceptive efficacy of a progesterone-releasing vaginal ring.
|
|
Contraception
|
|
1985;32:603-22.
|
|
[<a href="https://pubmed.ncbi.nlm.nih.gov/3912105" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 3912105</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>11.</dt><dd><div class="bk_ref" id="LM470.REF.11">Shaaban
|
|
MM. Contraception with progestogens and progesterone during lactation.
|
|
J Steroid Biochem Mol Biol
|
|
1991;40:705-10.
|
|
[<a href="https://pubmed.ncbi.nlm.nih.gov/1835650" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 1835650</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>12.</dt><dd><div class="bk_ref" id="LM470.REF.12">Díaz
|
|
S, Zepeda
|
|
A, Maturana
|
|
X, et al.
|
|
Fertility regulation in nursing women IX. Contraceptive performance, duration of lactation, infant gowth, and bleeding patterns during use of progesterone vaginal rings, progestin-only pills, Norplant® implants, and Copper T 380-A intrauterine devices.
|
|
Contraception
|
|
1997;56:223-32.
|
|
[<a href="https://pubmed.ncbi.nlm.nih.gov/9408703" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9408703</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>13.</dt><dd><div class="bk_ref" id="LM470.REF.13">Chen
|
|
JH, Wu
|
|
SC, Shao
|
|
WQ, et al.
|
|
The comparative trial of TCu 380A IUD and progesterone-releasing vaginal ring used by lactating women.
|
|
Contraception
|
|
1998;57:371-9.
|
|
[<a href="https://pubmed.ncbi.nlm.nih.gov/9693396" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9693396</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>14.</dt><dd><div class="bk_ref" id="LM470.REF.14">Massai
|
|
R, Miranda
|
|
P, Valdés
|
|
P, et al.
|
|
Preregistration study on the safety and contraceptive efficacy of a progesterone-releasing vaginal ring in Chilean nursing women.
|
|
Contraception
|
|
1999;60:9-14.
|
|
[<a href="https://pubmed.ncbi.nlm.nih.gov/10549447" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 10549447</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>15.</dt><dd><div class="bk_ref" id="LM470.REF.15">Roy
|
|
M, Hazra
|
|
A, Merkatz
|
|
R, et al.
|
|
Progesterone vaginal ring as a new contraceptive option for lactating mothers: Evidence from a multicenter non-randomized comparative clinical trial in India.
|
|
Contraception
|
|
2020;102:159-67.
|
|
[<a href="/pmc/articles/PMC7483628/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC7483628</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/32360666" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 32360666</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>16.</dt><dd><div class="bk_ref" id="LM470.REF.16">Croxatto HB, Díaz S. Progesterone vaginal rings for contraception during breastfeeding. In: Runnebaum R, Rabe T, Kiesel L, eds. Advances in gynecological and obstetric research series Vol 2 Female contraception and male fertility regulation. New Jersey: Parthenon; 1987:135-42.</div></dd></dl><dl class="bkr_refwrap"><dt>17.</dt><dd><div class="bk_ref" id="LM470.REF.17">Sivin
|
|
I, Díaz
|
|
S, Croxatto
|
|
HB, et al.
|
|
Contraceptives for lactating women: A comparative trial of a progesterone-releasing vaginal ring and the copper T 380A IUD.
|
|
Contraception
|
|
1997;55:225-32.
|
|
[<a href="https://pubmed.ncbi.nlm.nih.gov/9179454" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9179454</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>18.</dt><dd><div class="bk_ref" id="LM470.REF.18">Massai
|
|
R, Quinteros
|
|
E, Reyes
|
|
MV, et al.
|
|
Extended use of a progesterone-releasing vaginal ring in nursing women: A phase II clinical trial.
|
|
Contraception
|
|
2005;72:352-7.
|
|
[<a href="https://pubmed.ncbi.nlm.nih.gov/16246661" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16246661</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>19.</dt><dd><div class="bk_ref" id="LM470.REF.19">Allen
|
|
SS, Allen
|
|
AM, Lunos
|
|
S, et al.
|
|
Progesterone and postpartum smoking relapse: A pilot double-blind placebo-controlled randomized trial.
|
|
Nicotine Tob Res
|
|
2016;18:2145-53.
|
|
[<a href="/pmc/articles/PMC5055745/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5055745</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/27613934" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27613934</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>20.</dt><dd><div class="bk_ref" id="LM470.REF.20">Reisman
|
|
T, Goldstein
|
|
Z.
|
|
Case report: Induced lactation in a transgender woman.
|
|
Transgend Health
|
|
2018;3:24-6.
|
|
[<a href="/pmc/articles/PMC5779241/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5779241</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/29372185" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 29372185</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>21.</dt><dd><div class="bk_ref" id="LM470.REF.21">Wamboldt
|
|
R, Shuster
|
|
S, Sidhu
|
|
BS. Lactation induction in a transgender woman wanting to breastfeed: Case report.
|
|
J Clin Endocrinol Metab
|
|
2021;106:e2047-e52.
|
|
[<a href="https://pubmed.ncbi.nlm.nih.gov/33513241" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 33513241</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>22.</dt><dd><div class="bk_ref" id="LM470.REF.22">Weimer
|
|
AK. Lactation induction in a transgender woman: Macronutrient analysis and patient perspectives.
|
|
J Hum Lact
|
|
2023;39:488-94.
|
|
[<a href="https://pubmed.ncbi.nlm.nih.gov/37138506" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 37138506</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>23.</dt><dd><div class="bk_ref" id="LM470.REF.23">Delgado
|
|
D, Stellwagen
|
|
L, McCune
|
|
S, et al.
|
|
Experience of induced lactation in a transgender woman: Analysis of human milk and a suggested protocol.
|
|
Breastfeed Med
|
|
2023;18:888-93.
|
|
[<a href="https://pubmed.ncbi.nlm.nih.gov/37910800" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 37910800</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>24.</dt><dd><div class="bk_ref" id="LM470.REF.24">van Amesfoort
|
|
JE, Van Mello
|
|
NM, van Genugten
|
|
R. Lactation induction in a transgender woman: Case report and recommendations for clinical practice.
|
|
Int Breastfeed J
|
|
2024;19:18.
|
|
[<a href="/pmc/articles/PMC10926588/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC10926588</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/38462609" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 38462609</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>25.</dt><dd><div class="bk_ref" id="LM470.REF.25">Trahair
|
|
ED, Kokosa
|
|
S, Weinhold
|
|
A, et al.
|
|
Novel lactation induction protocol for a transgender woman wishing to breastfeed: A case report.
|
|
Breastfeed Med
|
|
2024;19:301-5.
|
|
[<a href="https://pubmed.ncbi.nlm.nih.gov/38535753" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 38535753</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>26.</dt><dd><div class="bk_ref" id="LM470.REF.26">Ikebukuro
|
|
S, Tanaka
|
|
M, Kaneko
|
|
M, et al.
|
|
Induced lactation in a transgender woman: Case report.
|
|
Int Breastfeed J
|
|
2024;19:66.
|
|
[<a href="/pmc/articles/PMC11411746/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC11411746</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/39300546" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 39300546</span></a>]</div></dd></dl></dl></div></div><div id="LM470.Substance_Identification"><h2 id="_LM470_Substance_Identification_">Substance Identification</h2><div id="LM470.Substance_Name"><h3>Substance Name</h3><p>Progesterone</p></div><div id="LM470.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>57-83-0</p></div><div id="LM470.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Hormones</p><p>Progesterone Congeners</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK501345_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">October 15, 2024</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Progesterone. [Updated 2024 Oct 15].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/lactmed/LM227/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/lactmed/LM228/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
|
|
|
|
|
|
|
|
|
|
<!-- Book content -->
|
|
|
|
<script type="text/javascript" src="/portal/portal3rc.fcgi/rlib/js/InstrumentNCBIBaseJS/InstrumentPageStarterJS.js"> </script>
|
|
|
|
|
|
<!-- CE8B5AF87C7FFCB1_0191SID /projects/books/PBooks@9.11 portal104 v4.1.r689238 Tue, Oct 22 2024 16:10:51 -->
|
|
<span id="portal-csrf-token" style="display:none" data-token="CE8B5AF87C7FFCB1_0191SID"></span>
|
|
|
|
<script type="text/javascript" src="//static.pubmed.gov/portal/portal3rc.fcgi/4216699/js/3968615.js" snapshot="books"></script></body>
|
|
</html>
|