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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]" /><meta name="citation_title" content="Cascara Sagrada" /><meta name="citation_publisher" content="National Institute of Child Health and Human Development" /><meta name="citation_date" content="2021/05/17" /><meta name="citation_pmid" content="30000387" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK501328/" /><meta name="citation_keywords" content="Vermilax" /><meta name="citation_keywords" content="Sagrada" /><meta name="citation_keywords" content="Cascara sagrada" /><meta name="citation_keywords" content="CASCARA" /><meta name="citation_keywords" content="Phenol, 2,2'-methylenebis(5-chloro-, mixt. with cascara sagrada and piperazine" /><meta name="citation_keywords" content="8047-27-6" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Cascara Sagrada" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Child Health and Human Development" /><meta name="DC.Date" content="2021/05/17" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK501328/" /><meta name="description" content="Maternal cascara intake might cause loose stools in some breastfed infants and should be avoided.[1] Other cathartics are preferred." /><meta name="og:title" content="Cascara Sagrada" /><meta name="og:type" content="book" /><meta name="og:description" content="Maternal cascara intake might cause loose stools in some breastfed infants and should be avoided.[1] Other cathartics are preferred." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK501328/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-lactmed-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/lactmed/LM452/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK501328/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK501328_"><span class="title" itemprop="name">Cascara Sagrada</span></h1><p class="small">Last Revision: <span itemprop="dateModified">May 17, 2021</span>.</p><p><em>Estimated reading time: 1 minute</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 8047-27-6</p><div id="LM452.Drug_Levels_and_Effects"><h2 id="_LM452_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM452.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Maternal cascara intake might cause loose stools in some breastfed infants and should be avoided.[<a class="bk_pop" href="#LM452.REF.1">1</a>] Other cathartics are preferred.</p></div><div id="LM452.Drug_Levels"><h3>Drug Levels</h3><p>After administration of 65 mg of cascara sagrada as cascara fluidextract, cascara was qualitatively detected in the breastmilk of 5 of 10 women collected over 20 hours.[<a class="bk_pop" href="#LM452.REF.2">2</a>] The sensitivity of the assay was about 1100 mg/L of cascara.</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM452.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>In 2 uncontrolled studies, a total of 10 of 22 breastfed neonates appeared to have loose stools after administration of 65 mg of cascara as cascara fluidextract to their mothers.[<a class="bk_pop" href="#LM452.REF.2">2</a>]</p><p>In an observational case series, no cases of diarrhea were observed among the breastfed infants of 142 mothers who received 400 mg of cascara extract on day 3 postpartum.[<a class="bk_pop" href="#LM452.REF.3">3</a>] This result might have been because of the small amount of colostrum received by the infants of this age.</p></div><div id="LM452.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM452.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p><a href="/books/n/lactmed/LM448/">Bisacodyl</a>, <a href="/books/n/lactmed/LM463/">Magnesium Hydroxide</a>, <a href="/books/n/lactmed/LM474/">Senna</a></p></div><div id="LM452.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="LM452.REF.1">Lewis JH, Weingold AB., Committee of FDA-Related Matters American College of Gastroenterology. The use of gastrointestinal drugs during pregnancy and lactation. <span><span class="ref-journal">Am J Gastroenterol. </span>1985;<span class="ref-vol">80</span>:912–23.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/2864852" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 2864852</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="LM452.REF.2">Tyson RM, Shrader EA, Perlman HH. Drugs transmitted through breast milk. Part I: Laxatives. <span><span class="ref-journal">J Pediatr. </span>1937;<span class="ref-vol">11</span>:824–32.</span> [<a href="http://dx.crossref.org/10.1016/S0022-3476(37)80040-2" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">CrossRef</a>]</div></dd><dt>3.</dt><dd><div class="bk_ref" id="LM452.REF.3">Duncan AS. Standardized senna as a laxative in the puerperium. A clinical assessment. <span><span class="ref-journal">Br Med J. </span>1957;<span class="ref-vol">1</span>:439–41.</span> [<a href="/pmc/articles/PMC1974525/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC1974525</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/13396280" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 13396280</span></a>]</div></dd></dl></div></div><div id="LM452.Substance_Identification"><h2 id="_LM452_Substance_Identification_">Substance Identification</h2><div id="LM452.Substance_Name"><h3>Substance Name</h3><p>Cascara Sagrada</p></div><div id="LM452.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>8047-27-6</p></div><div id="LM452.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Cathartics</p><p>Gastrointestinal Agents</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div><div class="small"><span class="label">Bookshelf ID: NBK501328</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/30000387" title="PubMed record of this page" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">30000387</a></span></div><div style="margin-top:2em" class="bk_noprnt"><a class="bk_cntns" href="/books/n/lactmed/">Contents</a><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/lactmed/LM286/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/lactmed/casirivimab/" title="Next page in this title">Next ></a></div></div></div></div>
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