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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]" /><meta name="citation_title" content="Bisacodyl" /><meta name="citation_publisher" content="National Institute of Child Health and Human Development" /><meta name="citation_date" content="2021/03/17" /><meta name="citation_pmid" content="30000382" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK501323/" /><meta name="citation_keywords" content="bisacodyl" /><meta name="citation_keywords" content="Dulcolax" /><meta name="citation_keywords" content="Brocalax" /><meta name="citation_keywords" content="Bicol" /><meta name="citation_keywords" content="Fenilaxan" /><meta name="citation_keywords" content="Durolax" /><meta name="citation_keywords" content="Endokolat" /><meta name="citation_keywords" content="Hillcolax" /><meta name="citation_keywords" content="Sanvacual" /><meta name="citation_keywords" content="Dulcolan" /><meta name="citation_keywords" content="Stadalax" /><meta name="citation_keywords" content="Theralax" /><meta name="citation_keywords" content="Eulaxan" /><meta name="citation_keywords" content="Godalax" /><meta name="citation_keywords" content="Laxadin" /><meta name="citation_keywords" content="Laxorex" /><meta name="citation_keywords" content="Nigalax" /><meta name="citation_keywords" content="Perilax" /><meta name="citation_keywords" content="Pyrilax" /><meta name="citation_keywords" content="Telemin" /><meta name="citation_keywords" content="Ulcolax" /><meta name="citation_keywords" content="Ivilax" /><meta name="citation_keywords" content="Laxans" /><meta name="citation_keywords" content="Laxine" /><meta name="citation_keywords" content="Neolax" /><meta name="citation_keywords" content="Zetrax" /><meta name="citation_keywords" content="Sk-bisacodyl" /><meta name="citation_keywords" content="Bisacodylum" /><meta name="citation_keywords" content="Bisacodilo" /><meta name="citation_keywords" content="Deficol" /><meta name="citation_keywords" content="Laxanin N" /><meta name="citation_keywords" content="HalfLytely" /><meta name="citation_keywords" content="603-50-9" /><meta name="citation_keywords" content="LACO" /><meta name="citation_keywords" content="Modane" /><meta name="citation_keywords" content="Evac-Q-Tabs" /><meta name="citation_keywords" content="LA96a" /><meta name="citation_keywords" content="Bisacodylum [INN-Latin]" /><meta name="citation_keywords" content="Feen-a-Mint Tablets" /><meta name="citation_keywords" content="Bisacodilo [INN-Spanish]" /><meta name="citation_keywords" content="UNII-10X0709Y6I" /><meta name="citation_keywords" content="Correctol Tablets, Caplets" /><meta name="citation_keywords" content="HSDB 3016" /><meta name="citation_keywords" content="CCRIS 8864" /><meta name="citation_keywords" content="Bis(p-acetoxyphenyl)-2-pyridylmethane" /><meta name="citation_keywords" content="Di-(p-acetoxyphenyl)-2-pyridylmethane" /><meta name="citation_keywords" content="Bisacodyl [USP:INN:BAN:JAN]" /><meta name="citation_keywords" content="Di-(4-acetoxyphenyl)-2-pyridylmethane" /><meta name="citation_keywords" content="EINECS 210-044-4" /><meta name="citation_keywords" content="2-(4,4'-Diacetoxydiphenylmethyl)pyridine" /><meta name="citation_keywords" content="BRN 0323727" /><meta name="citation_keywords" content="(4,4'-Diacetoxydiphenyl)(2-pyridyl)methane" /><meta name="citation_keywords" content="10X0709Y6I" /><meta name="citation_keywords" content="4,4'-(2-Pyridylmethylene)diphenol diacetate" /><meta name="citation_keywords" content="Phenol, 4,4'-(2-pyridinylmethylene)bis-, diacetate (ester)" /><meta name="citation_keywords" content="4,4'-(2-Pyridylmethylene)diphenol diacetate (ester)" /><meta name="citation_keywords" content="Phenol, 4,4'-(2-pyridylmethylene)di-, diacetate (ester)" /><meta name="citation_keywords" content="Phenol, 4,4'-(2-pyridinylmethylene)bis-, 1,1'-diacetate" /><meta name="citation_keywords" content="5-21-05-00415 (Beilstein Handbook Reference)" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Bisacodyl" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Child Health and Human Development" /><meta name="DC.Date" content="2021/03/17" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK501323/" /><meta name="description" content="Bisacodyl is not absorbed from the gastrointestinal tract, and its active metabolite, which is absorbed, is not detectable in breastmilk. 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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK501323_"><span class="title" itemprop="name">Bisacodyl</span></h1><p class="small">Last Revision: <span itemprop="dateModified">March 17, 2021</span>.</p><p><em>Estimated reading time: 1 minute</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 603-50-9</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134976919" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134976919" alt="image 134976919 in the ncbi pubchem database" /></a><div id="LM448.Drug_Levels_and_Effects"><h2 id="_LM448_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM448.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Bisacodyl is not absorbed from the gastrointestinal tract, and its active metabolite, which is absorbed, is not detectable in breastmilk. Bisacodyl can be taken during breastfeeding and no special precautions are required.</p></div><div id="LM448.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Sixteen postpartum women who were not breastfeeding, but were producing at least 200 mL of milk daily by breast pump were given either oral enteric-coated bisacodyl tablets (Dulcolax) 10 mg daily or oral liquid sodium picosulfate (Laxoberal) 10 mg daily for 7 days. Both drugs are prodrugs metabolized to the active drug, bis-(p-hydroxyphenyl)-2-pyridyl-2-methane (BHPM). All breastmilk was collected daily from the day before drug administration to 2 days after the last dose. Free and conjugated BHPM were undetectable (<1 mcg/L) in all milk samples.[<a class="bk_pop" href="#LM448.REF.1">1</a>]</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM448.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM448.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM448.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p><a href="/books/n/lactmed/LM456/">Docusate</a>, <a href="/books/n/lactmed/LM463/">Magnesium Hydroxide</a>, <a href="/books/n/lactmed/LM471/">Psyllium</a>, <a href="/books/n/lactmed/LM474/">Senna</a></p></div><div id="LM448.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="LM448.REF.1">Friedrich C, Richter E, Trommeshauser D, et al. Lack of excretion of the active moiety of bisacodyl and sodium picosulfate into human breast milk: an open-label, parallel group, multiple dose study in healthy lactating women. <span><span class="ref-journal">Drug Metab Pharmacokinet. </span>2011;<span class="ref-vol">26</span>:458–64.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/21697613" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21697613</span></a>]</div></dd></dl></div></div><div id="LM448.Substance_Identification"><h2 id="_LM448_Substance_Identification_">Substance Identification</h2><div id="LM448.Substance_Name"><h3>Substance Name</h3><p>Bisacodyl</p></div><div id="LM448.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>603-50-9</p></div><div id="LM448.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Cathartics</p><p>Gastrointestinal Agents</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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