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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Aminosalicylic Acid - Drugs and Lactation Database (LactMed®) - NCBI Bookshelf</title>
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<meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]">
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<meta name="citation_title" content="Aminosalicylic Acid">
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<meta name="citation_publisher" content="National Institute of Child Health and Human Development">
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<meta name="citation_date" content="2024/08/15">
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<meta name="citation_keywords" content="4-Aminosalicylic acid">
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<meta name="citation_keywords" content="4-Amino-2-hydroxybenzoic acid">
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<meta name="citation_keywords" content="Aminosalicylic acid">
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<meta name="citation_keywords" content="Rezipas">
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<meta name="citation_keywords" content="Aminopar">
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<meta name="citation_keywords" content="Pamisyl">
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<meta name="citation_keywords" content="Parasalindon">
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<meta name="citation_keywords" content="Deapasil">
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<meta name="citation_keywords" content="Ferrosan">
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<meta name="citation_keywords" content="Parasal">
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<meta name="citation_keywords" content="Apacil">
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<meta name="citation_keywords" content="Paser">
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<meta name="citation_keywords" content="Parasalicil">
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<meta name="citation_keywords" content="Gabbropas">
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<meta name="citation_keywords" content="Paramycin">
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<meta name="citation_keywords" content="Pasnodia">
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<meta name="citation_keywords" content="Entepas">
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<meta name="citation_keywords" content="Pamacyl">
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<meta name="citation_keywords" content="Pasalon">
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<meta name="citation_keywords" content="Pasdium">
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<meta name="citation_keywords" content="Pasolac">
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<meta name="citation_keywords" content="Propasa">
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<meta name="citation_keywords" content="Aminox">
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<meta name="citation_keywords" content="Osacyl">
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<meta name="citation_keywords" content="Pasara">
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<meta name="citation_keywords" content="Pasmed">
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<meta name="citation_keywords" content="Pasem">
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<meta name="citation_keywords" content="Pasa">
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<meta name="citation_keywords" content="Hellipidyl">
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<meta name="citation_keywords" content="Pascorbic">
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<meta name="citation_keywords" content="p-aminosalicylic acid">
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<meta name="citation_keywords" content="Sanipirol-4">
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<meta name="citation_keywords" content="Para-Pas">
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<meta name="citation_keywords" content="Aminosalyl">
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<meta name="citation_keywords" content="APAS">
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<meta name="citation_keywords" content="Helipidyl">
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<meta name="citation_keywords" content="PASK">
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<meta name="citation_keywords" content="Paser Granules">
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<meta name="citation_keywords" content="para-Amino salicylic acid">
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<meta name="citation_keywords" content="PAS (acid)">
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<meta name="citation_keywords" content="PAS-C">
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<meta name="citation_keywords" content="2-Hydroxy-4-aminobenzoic acid">
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<meta name="citation_keywords" content="Kyselina p-aminosalicylova">
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<meta name="citation_keywords" content="Salicylic acid, 4-amino-">
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<meta name="citation_keywords" content="3-Hydroxy-4-carboxyaniline">
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<meta name="citation_keywords" content="Benzoic acid, 4-amino-2-hydroxy-">
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<meta name="citation_keywords" content="PAS (VAN)">
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<meta name="citation_keywords" content="UNII-5B2658E0N2">
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<meta name="citation_keywords" content="HSDB 3203">
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<meta name="citation_keywords" content="Kyselina p-aminosalicylova [Czech]">
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<meta name="citation_keywords" content="EINECS 200-613-5">
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<meta name="citation_keywords" content="BRN 0473071">
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<meta name="citation_keywords" content="A 1909">
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<meta name="citation_keywords" content="5B2658E0N2">
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<meta name="citation_keywords" content="PAS">
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<meta name="description" content="Limited information indicates that maternal aminosalicylic acid therapy produces low levels in milk and would not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months. Exclusively breastfed infants should be monitored for rare instances of jaundice, gastrointestinal disturbances, hypokalemia, thrombocytopenia, hemolysis and hypokalemia if this drug is used during lactation.[1]">
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<meta name="og:description" content="Limited information indicates that maternal aminosalicylic acid therapy produces low levels in milk and would not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months. Exclusively breastfed infants should be monitored for rare instances of jaundice, gastrointestinal disturbances, hypokalemia, thrombocytopenia, hemolysis and hypokalemia if this drug is used during lactation.[1]">
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class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK501320_"><span class="title" itemprop="name">Aminosalicylic Acid</span></h1><p class="fm-aai"><a href="#_NBK501320_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 1 minute</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><p>CASRN: 65-49-6</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134972628" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134972628" alt="image 134972628 in the ncbi pubchem database" /></a><div id="LM445.Drug_Levels_and_Effects"><h2 id="_LM445_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM445.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Limited information indicates that maternal aminosalicylic acid therapy produces low levels in milk and would not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months. Exclusively breastfed infants should be monitored for rare instances of jaundice, gastrointestinal disturbances, hypokalemia, thrombocytopenia, hemolysis and hypokalemia if this drug is used during lactation.[<a class="bibr" href="#LM445.REF.1" rid="LM445.REF.1">1</a>]</p></div><div id="LM445.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> One woman who was lactating, but not breastfeeding (time postpartum not stated) took a single 4 gram oral dose of aminosalicylic acid. A peak milk level of 1.1 mg/L occurred 3 hours after the dose. The drug's half-life in milk was estimated to be 2.5 hours.[<a class="bibr" href="#LM445.REF.1" rid="LM445.REF.1">1</a>] Using these data, a fully breastfed infant would receive a maximum of about 0.25% of the maternal weight-adjusted dosage.</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM445.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Aminosalicylic acid was used as part of multi-drug regimens to treat 2 pregnant women with multidrug-resistant tuberculosis throughout pregnancy and postpartum. Their two infants were breastfed (extent and duration not stated). At age 1.8 and 4.6 years, the children were developing normally, except for except for a mild speech delay in one at age 1.8 years, and failure to thrive in the other, possibly due to tuberculosis contracted after birth.[<a class="bibr" href="#LM445.REF.2" rid="LM445.REF.2">2</a>]</p></div><div id="LM445.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM445.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="LM445.REF.1">Holdiness
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MR. Antituberculosis drugs and breast-feeding.
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Arch Intern Med
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1984;144:1888.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/6548112" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 6548112</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="LM445.REF.2">Drobac
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PC, del Castillo
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H, Sweetland
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A, et al.
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Treatment of multidrug-resistant tuberculosis during pregnancy: Long-term follow-up of 6 children with intrauterine exposure to second-line agents.
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Clin Infect Dis
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2005;40:1689-92.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/15889370" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15889370</span></a>]</div></dd></dl></dl></div></div><div id="LM445.Substance_Identification"><h2 id="_LM445_Substance_Identification_">Substance Identification</h2><div id="LM445.Substance_Name"><h3>Substance Name</h3><p>Aminosalicylic Acid</p></div><div id="LM445.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>65-49-6</p></div><div id="LM445.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Anti-infective Agents</p><p>Antitubercular Agents</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK501320_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">August 15, 2024</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Aminosalicylic Acid. [Updated 2024 Aug 15].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/lactmed/LM9/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/lactmed/LM10/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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