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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK501320_"><span class="title" itemprop="name">Aminosalicylic Acid</span></h1><p class="small">Last Revision: <span itemprop="dateModified">August 15, 2024</span>.</p><p><em>Estimated reading time: 1 minute</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 65-49-6</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134972628" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134972628" alt="image 134972628 in the ncbi pubchem database" /></a><div id="LM445.Drug_Levels_and_Effects"><h2 id="_LM445_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM445.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Limited information indicates that maternal aminosalicylic acid therapy produces low levels in milk and would not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months. Exclusively breastfed infants should be monitored for rare instances of jaundice, gastrointestinal disturbances, hypokalemia, thrombocytopenia, hemolysis and hypokalemia if this drug is used during lactation.[<a class="bk_pop" href="#LM445.REF.1">1</a>]</p></div><div id="LM445.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> One woman who was lactating, but not breastfeeding (time postpartum not stated) took a single 4 gram oral dose of aminosalicylic acid. A peak milk level of 1.1 mg/L occurred 3 hours after the dose. The drug's half-life in milk was estimated to be 2.5 hours.[<a class="bk_pop" href="#LM445.REF.1">1</a>] Using these data, a fully breastfed infant would receive a maximum of about 0.25% of the maternal weight-adjusted dosage.</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM445.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Aminosalicylic acid was used as part of multi-drug regimens to treat 2 pregnant women with multidrug-resistant tuberculosis throughout pregnancy and postpartum. Their two infants were breastfed (extent and duration not stated). At age 1.8 and 4.6 years, the children were developing normally, except for except for a mild speech delay in one at age 1.8 years, and failure to thrive in the other, possibly due to tuberculosis contracted after birth.[<a class="bk_pop" href="#LM445.REF.2">2</a>]</p></div><div id="LM445.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM445.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="LM445.REF.1">Holdiness
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MR. Antituberculosis drugs and breast-feeding.
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Arch Intern Med
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1984;144:1888.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/6548112" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 6548112</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="LM445.REF.2">Drobac
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PC, del Castillo
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H, Sweetland
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A, et al.
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Treatment of multidrug-resistant tuberculosis during pregnancy: Long-term follow-up of 6 children with intrauterine exposure to second-line agents.
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Clin Infect Dis
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2005;40:1689-92.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/15889370" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15889370</span></a>]</div></dd></dl></div></div><div id="LM445.Substance_Identification"><h2 id="_LM445_Substance_Identification_">Substance Identification</h2><div id="LM445.Substance_Name"><h3>Substance Name</h3><p>Aminosalicylic Acid</p></div><div id="LM445.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>65-49-6</p></div><div id="LM445.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Anti-infective Agents</p><p>Antitubercular Agents</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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