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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Cefazolin - Drugs and Lactation Database (LactMed®) - NCBI Bookshelf</title>
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<meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]">
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<meta name="citation_title" content="Cefazolin">
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<meta name="citation_publisher" content="National Institute of Child Health and Human Development">
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<meta name="citation_keywords" content="Cephazolin">
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<meta name="citation_keywords" content="Cefazoline">
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<meta name="citation_keywords" content="Cephamezine">
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<meta name="citation_keywords" content="Cephazoline">
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<meta name="citation_keywords" content="Cefamezin">
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<meta name="citation_keywords" content="Cephazolidin">
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<meta name="citation_keywords" content="Cefazolinum">
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<meta name="citation_keywords" content="Cefazolina">
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<meta name="citation_keywords" content="Elzogram">
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<meta name="citation_keywords" content="Ancef">
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<meta name="citation_keywords" content="(6R,7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid">
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class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK501303_"><span class="title" itemprop="name">Cefazolin</span></h1><p class="fm-aai"><a href="#_NBK501303_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 1 minute</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><p>CASRN: 25953-19-9</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134996825" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134996825" alt="image 134996825 in the ncbi pubchem database" /></a><div id="LM43.Drug_Levels_and_Effects"><h2 id="_LM43_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM43.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Limited information indicates cefazolin produces low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with cephalosporins, but these effects have not been adequately evaluated. Cefazolin is acceptable in nursing mothers.</p></div><div id="LM43.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> After a single 500 mg dose of cefazolin intramuscularly to 4 women, cefazolin was barely detectable in the mother's milk and not detected in their breastfed infants' serum.[<a class="bibr" href="#LM43.REF.1" rid="LM43.REF.1">1</a>]</p><p>After intramuscular doses of cefazolin 500 mg three times daily in 10 women, the peak concentration of cefazolin in milk was 0.9 mg/L.[<a class="bibr" href="#LM43.REF.2" rid="LM43.REF.2">2</a>]</p><p>Twenty women were given 2 grams of cefazolin intravenously over 10 minutes. Average milk levels were 1.25 mg/L at 2 hours, 1.51 mg/L at 3 hours and 1.16 mg/L at 4 hours after the dose.[<a class="bibr" href="#LM43.REF.3" rid="LM43.REF.3">3</a>]</p><p>After a single dose of 1 gram of cefazolin given intravenously to 15 women who were 1 month postpartum, milk cefazolin levels averaged 0.75 mg/L 2 hours after the dose.[<a class="bibr" href="#LM43.REF.4" rid="LM43.REF.4">4</a>]</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM43.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM43.Effects_on_Lactation_and_Breastmilk"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM43.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p>(Methicillin-sensitive <i>Staph. aureus</i>) <a href="/books/n/lactmed/LM90/?report=reader">Cephalexin</a>, <a href="/books/n/lactmed/LM60/?report=reader">Dicloxacillin</a>, <a href="/books/n/lactmed/LM1083/?report=reader">Floxacillin</a>, <a href="/books/n/lactmed/LM206/?report=reader">Oxacillin</a>, <a href="/books/n/lactmed/LM176/?report=reader">Methicillin</a>, <a href="/books/n/lactmed/LM193/?report=reader">Nafcillin</a>; (Methicillin-resistant <i>Staph. aureus</i>) <a href="/books/n/lactmed/LM100/?report=reader">Doxycycline</a>, <a href="/books/n/lactmed/LM797/?report=reader">Linezolid</a>, <a href="/books/n/lactmed/LM183/?report=reader">Minocycline</a>, <a href="/books/n/lactmed/LM417/?report=reader">Trimethoprim-Sulfamethoxazole</a>, <a href="/books/n/lactmed/LM394/?report=reader">Vancomycin</a></p></div><div id="LM43.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="LM43.REF.1">Fukada
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M.
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Studies on chemotherapy during the perinatal period with special reference to such derivatives of cephalosporin C as cefazolin, cephaloridine and cephalothin.
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Jpn J Antibiot
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1973;26:197-214.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/4542543" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 4542543</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="LM43.REF.2">von Kobyletzki
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D, Reither
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K, Gellen
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J, et al.
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Pharmakokinetische untersuchungen mit cefazolin in geburtshilfe und gynakologie.
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Infection
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1974;2 (Suppl 1):60-7.</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="LM43.REF.3">Yoshioka
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H, Cho
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K, Takimoto
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M, et al.
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Transfer of cefazolin into human milk.
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J Pediatr
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1979;94:151-2.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/758399" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 758399</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>4.</dt><dd><div class="bk_ref" id="LM43.REF.4">Zhang
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Y, Zhang
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Q, Xu
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Z. Tissue and body fluid distribution of antibacterial agents in pregnant and lactating women.
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Zhonghua Fu Chan Ke Za Zhi
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1997;32:288-92.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/9596854" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9596854</span></a>]</div></dd></dl></dl></div></div><div id="LM43.Substance_Identification"><h2 id="_LM43_Substance_Identification_">Substance Identification</h2><div id="LM43.Substance_Name"><h3>Substance Name</h3><p>Cefazolin</p></div><div id="LM43.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>25953-19-9</p></div><div id="LM43.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Anti-Infective Agents</p><p>Antibacterial Agents</p><p>Cephalosporins</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK501303_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">November 15, 2024</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Cefazolin. [Updated 2024 Nov 15].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/lactmed/LM42/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/lactmed/LM44/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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