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class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK501283_"><span class="title" itemprop="name">Lansoprazole</span></h1><p class="fm-aai"><a href="#_NBK501283_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 2 minutes</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><p>CASRN: 103577-45-3</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/135017944" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=135017944" alt="image 135017944 in the ncbi pubchem database" /></a><div id="LM411.Drug_Levels_and_Effects"><h2 id="_LM411_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM411.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>No information is available on the use of lansoprazole during breastfeeding. However, lansoprazole has been used safely in newborn infants, so it is unlikely that the amount in breastmilk would be harmful.</p></div><div id="LM411.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Relevant published information was not found as of the revision date.</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM411.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM411.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>The Spanish pharmacovigilance system found 3 cases of gynecomastia associated with lansoprazole reported during the time period of 1982 to 2006.[<a class="bibr" href="#LM411.REF.1" rid="LM411.REF.1">1</a>] A retrospective claims database study in the United States found that users of proton pump inhibitors had an increased risk of gynecomastia.[<a class="bibr" href="#LM411.REF.2" rid="LM411.REF.2">2</a>]</p><p>A review article reported that a search of database from the European Pharmacovigilance Centre found 45 cases of gynecomastia, 11 cases of galactorrhea, 3 cases of breast pain and 5 cases of breast enlargement associated with lansoprazole. A search of the WHO global pharmacovigilance database found 123 cases of gynecomastia, 30 cases of galactorrhea, 36 cases of breast pain and 18 cases of breast enlargement associated with lansoprazole.[<a class="bibr" href="#LM411.REF.3" rid="LM411.REF.3">3</a>]</p><p>In a retrospective study, out of total of 127 cases of gynecomastia in of 175 male patients, 11 patients were treated had been treated with lansoprazole.[<a class="bibr" href="#LM411.REF.4" rid="LM411.REF.4">4</a>]</p><p>One case of elevated serum prolactin and galactorrhea was reported in a 21-year-old man. When omeprazole was substituted for lansoprazole, the serum prolactin decreased to the normal range and galactorrhea ceased. Although this case occurred in Spain, it was not included in the report above.[<a class="bibr" href="#LM411.REF.5" rid="LM411.REF.5">5</a>]</p><p>A 13-year-old girl with a recent history of bilateral galactorrhea and hyperprolactinemia from omeprazole and domperidone on separate occasions was given lansoprazole to prevent gastrointestinal irritation following intravenous diclofenac for a severe headache. After 3 days of lansoprazole therapy, she again developed galactorrhea and an elevated serum prolactin that returned to normal a week after discontinuing lansoprazole.[<a class="bibr" href="#LM411.REF.6" rid="LM411.REF.6">6</a>]</p><p>A 17-year-old woman using a progestin-containing IUD for 1 year began lansoprazole 15 mg daily and presented after 1 week with bilateral galactorrhea and hyperprolactinemia of 92 mcg/L. Seventy-two hours after discontinuation of lansoprazole, galactorrhea ceased. Four months later, serum prolactin was normal at 24.1 mcg/L with no recurrence of galactorrhea. The authors judged the adverse reaction likely to be caused by lansoprazole.[<a class="bibr" href="#LM411.REF.7" rid="LM411.REF.7">7</a>]</p><p>The prolactin level in a mother with established lactation may not affect her ability to breastfeed.</p></div><div id="LM411.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p><a href="/books/n/lactmed/LM447/?report=reader">Antacids</a>, <a href="/books/n/lactmed/LM341/?report=reader">Cimetidine</a>, <a href="/books/n/lactmed/LM398/?report=reader">Famotidine</a>, <a href="/books/n/lactmed/LM375/?report=reader">Omeprazole</a>, <a href="/books/n/lactmed/LM409/?report=reader">Pantoprazole</a>, <a href="/books/n/lactmed/LM475/?report=reader">Sucralfate</a></p></div><div id="LM411.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="LM411.REF.1">Carvajal
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A, Macias
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D, Gutierrez
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A, et al.
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Gynaecomastia associated with proton pump inhibitors: A case series from the Spanish Pharmacovigilance System.
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Drug Saf
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2007;30:527-31.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/17536878" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 17536878</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="LM411.REF.2">He
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B, Carleton
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B, Etminan
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M. Risk of gynecomastia with users of proton pump inhibitors.
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Pharmacotherapy
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2019;39:614-8.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/30865318" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 30865318</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="LM411.REF.3">Ashfaq
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M, Haroon
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MZ, Alkahraman
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YM. Proton pump inhibitors therapy and risk of hyperprolactinemia with associated sexual disorders.
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Endocr Regul
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2022;56:134-47.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/35489049" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 35489049</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>4.</dt><dd><div class="bk_ref" id="LM411.REF.4">Daniels
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IR, Layer
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GT. How should gynaecomastia be managed?
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ANZ J Surg
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2003;73:213-6. doi:10.1046/j.1445-1433.2002.02584.x
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[<a href="https://pubmed.ncbi.nlm.nih.gov/12662229" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12662229</span></a>] [<a href="http://dx.crossref.org/10.1046/j.1445-1433.2002.02584.x" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">CrossRef</a>]</div></dd></dl><dl class="bkr_refwrap"><dt>5.</dt><dd><div class="bk_ref" id="LM411.REF.5">Izquierdo Prieto
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OM, Moreno Alia
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E, Rosillo González
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A. [Galactorrhea induced by lansoprazole]. Aten Primaria
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2004;34:325-6.
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[<a href="/pmc/articles/PMC7668912/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC7668912</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/15491529" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15491529</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>6.</dt><dd><div class="bk_ref" id="LM411.REF.6">Jabbar
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A, Khan
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R, Farrukh
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SN. Hyperprolactinaemia induced by proton pump inhibitor.
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J Pak Med Assoc
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2010;60:689-90.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/20726208" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 20726208</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>7.</dt><dd><div class="bk_ref" id="LM411.REF.7">Duwicquet
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F, Gras-Champel
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V, Masmoudi
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K. Hyperprolactinemia with galactorrhea induced by lansoprazole: A case report.
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Therapie
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2017;72:691-3.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/29061292" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 29061292</span></a>]</div></dd></dl></dl></div></div><div id="LM411.Substance_Identification"><h2 id="_LM411_Substance_Identification_">Substance Identification</h2><div id="LM411.Substance_Name"><h3>Substance Name</h3><p>Lansoprazole</p></div><div id="LM411.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>103577-45-3</p></div><div id="LM411.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Anti-Ulcer Agents</p><p>Gastrointestinal Agents</p><p>Proton Pump Inhibitors</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK501283_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">February 15, 2025</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Lansoprazole. [Updated 2025 Feb 15].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/lactmed/LM1475/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/lactmed/lanthanum_CO3/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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