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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Temazepam - Drugs and Lactation Database (LactMed®) - NCBI Bookshelf</title>
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<meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]">
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<meta name="citation_title" content="Temazepam">
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<meta name="citation_publisher" content="National Institute of Child Health and Human Development">
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<meta name="citation_date" content="2024/09/15">
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<meta name="citation_keywords" content="temazepam">
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<meta name="citation_keywords" content="Restoril">
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<meta name="citation_keywords" content="Hydroxydiazepam">
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<meta name="citation_keywords" content="Methyloxazepam">
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<meta name="citation_keywords" content="Oxydiazepam">
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<meta name="citation_keywords" content="Levanxol">
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<meta name="citation_keywords" content="Levanxene">
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<meta name="citation_keywords" content="Crisonar">
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<meta name="citation_keywords" content="Euhypnos">
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<meta name="citation_keywords" content="Signopam">
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<meta name="citation_keywords" content="Mabertin">
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<meta name="citation_keywords" content="Normison">
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<meta name="citation_keywords" content="Remestan">
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<meta name="citation_keywords" content="Planum">
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<meta name="citation_keywords" content="N-Methyloxazepam">
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<meta name="citation_keywords" content="Cerepax">
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<meta name="citation_keywords" content="Temaz">
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<meta name="citation_keywords" content="Dasuen">
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<meta name="citation_keywords" content="Nortem">
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<meta name="citation_keywords" content="3-Hydroxydiazepam">
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<meta name="citation_keywords" content="Norkotral Tema">
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<meta name="citation_keywords" content="temazep von ct">
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<meta name="citation_keywords" content="Temazepamum">
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<meta name="citation_keywords" content="Nomapam">
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<meta name="citation_keywords" content="Pronervon T">
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<meta name="citation_keywords" content="Temador">
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<meta name="citation_keywords" content="Lenal">
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<meta name="citation_keywords" content="Uvamin Retard">
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<meta name="citation_keywords" content="Neodorm SP">
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<meta name="citation_keywords" content="Strazepam">
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<meta name="citation_keywords" content="WY 3917">
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<meta name="citation_keywords" content="DEA No. 2925">
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<meta name="description" content="Because of the low levels of temazepam in breastmilk and its relatively short half-life, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants. Taking the bedtime dose after the infant's last feeding of the day may minimize the dose received by an older infant who is sleeping through the night. Monitor the infant for sedation, poor feeding and poor weight gain.">
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class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK501256_"><span class="title" itemprop="name">Temazepam</span></h1><p class="fm-aai"><a href="#_NBK501256_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 2 minutes</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><p>CASRN: 846-50-4</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134979721" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134979721" alt="image 134979721 in the ncbi pubchem database" /></a><div id="LM388.Drug_Levels_and_Effects"><h2 id="_LM388_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM388.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Because of the low levels of temazepam in breastmilk and its relatively short half-life, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants. Taking the bedtime dose after the infant's last feeding of the day may minimize the dose received by an older infant who is sleeping through the night. Monitor the infant for sedation, poor feeding and poor weight gain.</p></div><div id="LM388.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> A woman who had been abusing benzodiazepines was taking diazepam 80 mg of diazepam as well as oxazepam. Temazepam is a metabolite of diazepam. Milk samples were taken before and after the morning feeding following the morning dose of diazepam during a 30-day tapering dosage regimen. The average of the pre- and post-feed temazepam milk levels were 13 and 18 mcg/L on days 14 and 15 during maternal intake of diazepam 40 mg daily. The average of the pre- and post-feed temazepam milk levels were 13 and 14 mcg/L on days 23 and 25 during maternal intake of diazepam 30 mg daily.[<a class="bibr" href="#LM388.REF.1" rid="LM388.REF.1">1</a>]</p><p>Ten women who were less than 15 days postpartum were given temazepam 10 or 20 mg (0.16 to 0.32 mg/kg) at bedtime once daily for at least 2 days prior to being studied. Milk samples were taken immediately before and after a feeding that ranged from 10.3 to 21.3 hours after the dose. Milk temazepam levels were undetectable (<5 mcg/L) in 9 of the 10 women. In the tenth who had a plasma temazepam of 234 mcg/L (several times higher than the other women), milk temazepam levels were 28 and 26 mcg/L before and after a feed that occurred 14.1 hours after the previous dose of temazepam. Oxazepam, a metabolite of temazepam, was undetectable (<5 mcg/L) in all of the subjects' milk samples.[<a class="bibr" href="#LM388.REF.2" rid="LM388.REF.2">2</a>]</p><p><i>Infant Levels.</i> Two breastfed infants had undetectable (<5 mcg/L) plasma levels of temazepam or its metabolite oxazepam 13.3 and 14.8 hours after maternal doses of temazepam 0.16 and 0.17 mg/kg orally.[<a class="bibr" href="#LM388.REF.2" rid="LM388.REF.2">2</a>]</p></div><div id="LM388.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Ten infants who were less than 15 days old were breastfed by mothers who had taken temazepam 10 or 20 mg (0.16 to 0.32 mg/kg) at bedtime once daily for at least 2 days. None of the infants had any observable adverse reactions.[<a class="bibr" href="#LM388.REF.2" rid="LM388.REF.2">2</a>]</p><p>In a telephone follow-up study, 124 mothers who took a benzodiazepine while nursing reported whether their infants had any signs of sedation. One mother took temazepam while breastfeeding and reported no sedation in her infant.[<a class="bibr" href="#LM388.REF.3" rid="LM388.REF.3">3</a>]</p></div><div id="LM388.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM388.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p><a href="/books/n/lactmed/LM395/?report=reader">Zaleplon</a>, <a href="/books/n/lactmed/LM396/?report=reader">Zolpidem</a></p></div><div id="LM388.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="LM388.REF.1">Dusci
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LJ, Good
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SM, Hall
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RW, et al.
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Excretion of diazepam and its metabolites in human milk during withdrawal from combination high dose diazepam and oxazepam.
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Br J Clin Pharmacol
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1990;29:123-6.
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[<a href="/pmc/articles/PMC1380071/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC1380071</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/2105100" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 2105100</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="LM388.REF.2">Lebedevs
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TH, Wojnar-Horton
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RE, Yapp
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P, et al.
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Excretion of temazepam in breast milk.
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Br J Clin Pharmacol
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1992;33:204-6.
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[<a href="/pmc/articles/PMC1381312/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC1381312</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/1550703" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 1550703</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="LM388.REF.3">Kelly
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LE, Poon
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S, Madadi
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P, et al.
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Neonatal benzodiazepines exposure during breastfeeding.
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J Pediatr
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2012;161:448-51.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/22504099" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 22504099</span></a>]</div></dd></dl></dl></div></div><div id="LM388.Substance_Identification"><h2 id="_LM388_Substance_Identification_">Substance Identification</h2><div id="LM388.Substance_Name"><h3>Substance Name</h3><p>Temazepam</p></div><div id="LM388.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>846-50-4</p></div><div id="LM388.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Hypnotics and Sedatives</p><p>Anti-Anxiety Agents</p><p>Benzodiazepines</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK501256_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">September 15, 2024</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Temazepam. [Updated 2024 Sep 15].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/lactmed/LM731/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/lactmed/LM1298/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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