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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Midazolam - Drugs and Lactation Database (LactMed®) - NCBI Bookshelf</title>
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<meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]">
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<meta name="citation_title" content="Midazolam">
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<meta name="citation_publisher" content="National Institute of Child Health and Human Development">
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<meta name="citation_date" content="2024/10/15">
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<meta name="citation_pmid" content="30000294">
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<meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK501235/">
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<meta name="citation_keywords" content="midazolam">
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<meta name="citation_keywords" content="Dormicum">
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<meta name="citation_keywords" content="Midazolamum">
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<meta name="citation_keywords" content="UNII-R60L0SM5BC">
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<meta name="citation_keywords" content="DEA No. 2884">
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<meta name="citation_keywords" content="R60L0SM5BC">
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<meta name="citation_keywords" content="Ro 21-3981">
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<meta name="citation_keywords" content="USL261">
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<meta name="citation_keywords" content="EINECS 261-774-5">
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<meta name="citation_keywords" content="HSDB 6751">
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<meta name="citation_keywords" content="BRN 0625572">
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<meta name="citation_keywords" content="Nayzilam">
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<meta name="citation_keywords" content="8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine">
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<meta name="DC.Title" content="Midazolam">
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<meta name="DC.Date" content="2024/10/15">
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<meta name="description" content="The small amounts of midazolam excreted into breastmilk would not be expected to cause adverse effects in most breastfed infants. A safety scoring system finds midazolam acceptable to use during breastfeeding.[1] Two expert panels advocates waiting for at least 4 hours after a single intravenous dose of midazolam (e.g., for endoscopy) before resuming nursing.[2,3] With a newborn or preterm infant a cautious approach would be to wait a period of 6 to 8 hours before resuming nursing. After general anesthesia, breastfeeding can resume as soon as the mother has recovered sufficiently from general anesthesia to nurse.[4-6] When a combination of anesthetic agents is used for a procedure, follow the recommendations for the most problematic medication used during the procedure. With prolonged use (days) of intravenous therapy, an active metabolite can accumulate in the mother and might affect the infant, but data in breastfeeding are lacking. Monitor the infant for sedation, poor feeding and poor weight gain.">
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<meta name="og:title" content="Midazolam">
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<meta name="og:description" content="The small amounts of midazolam excreted into breastmilk would not be expected to cause adverse effects in most breastfed infants. A safety scoring system finds midazolam acceptable to use during breastfeeding.[1] Two expert panels advocates waiting for at least 4 hours after a single intravenous dose of midazolam (e.g., for endoscopy) before resuming nursing.[2,3] With a newborn or preterm infant a cautious approach would be to wait a period of 6 to 8 hours before resuming nursing. After general anesthesia, breastfeeding can resume as soon as the mother has recovered sufficiently from general anesthesia to nurse.[4-6] When a combination of anesthetic agents is used for a procedure, follow the recommendations for the most problematic medication used during the procedure. With prolonged use (days) of intravenous therapy, an active metabolite can accumulate in the mother and might affect the infant, but data in breastfeeding are lacking. Monitor the infant for sedation, poor feeding and poor weight gain.">
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class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK501235_"><span class="title" itemprop="name">Midazolam</span></h1><p class="fm-aai"><a href="#_NBK501235_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 3 minutes</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><p>CASRN: 59467-70-8</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/135006020" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=135006020" alt="image 135006020 in the ncbi pubchem database" /></a><div id="LM369.Drug_Levels_and_Effects"><h2 id="_LM369_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM369.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>The small amounts of midazolam excreted into breastmilk would not be expected to cause adverse effects in most breastfed infants. A safety scoring system finds midazolam acceptable to use during breastfeeding.[<a class="bibr" href="#LM369.REF.1" rid="LM369.REF.1">1</a>] Two expert panels advocates waiting for at least 4 hours after a single intravenous dose of midazolam (e.g., for endoscopy) before resuming nursing.[<a class="bibr" href="#LM369.REF.2" rid="LM369.REF.2">2</a>,<a class="bibr" href="#LM369.REF.3" rid="LM369.REF.3">3</a>] With a newborn or preterm infant a cautious approach would be to wait a period of 6 to 8 hours before resuming nursing. After general anesthesia, breastfeeding can resume as soon as the mother has recovered sufficiently from general anesthesia to nurse.[<a class="bibr" href="#LM369.REF.4" rid="LM369.REF.4">4</a>-<a class="bibr" href="#LM369.REF.6" rid="LM369.REF.6">6</a>] When a combination of anesthetic agents is used for a procedure, follow the recommendations for the most problematic medication used during the procedure. With prolonged use (days) of intravenous therapy, an active metabolite can accumulate in the mother and might affect the infant, but data in breastfeeding are lacking. Monitor the infant for sedation, poor feeding and poor weight gain.</p></div><div id="LM369.Drug_Levels"><h3>Drug Levels</h3><p>Midazolam is about 36% bioavailable orally in adults. It is metabolized to 1-hydroxymidazolam (60 to 70%) and 4-hydroxymidazolam (5%) which are about equipotent to midazolam. The half-life of 1-hydroxymidazolam is about 12 hours in adults and can accumulate with prolonged or repeated doses or in renal impairment.</p><p><i>Maternal Levels.</i> Twelve mothers were given a total of 30 doses of oral midazolam 15 mg for sleep in the first 5 days postpartum if they requested it. In 11 of the mothers, midazolam was unmeasurable (<3 mcg/L) in breastmilk 7 hours after the dose. One of the mothers accidentally took a second tablet (30 mg total) on one occasion and had a 7-hour milk level of 9 mcg/L. No accumulation occurred with repeated nightly doses in any of the mothers. Two additional women who were 2 to 3 months postpartum had hourly milk sampling after a single 15 mg dose. Peak milk levels of both the drug and metabolite occurred at 1 and 2 hours after the dose in the 2 patients. Peak milk levels of midazolam plus 1-hydroxymidazolam were about 13 mcg/L and the average milk level over the 7-hour period was 6.7 mcg/L.[<a class="bibr" href="#LM369.REF.7" rid="LM369.REF.7">7</a>] Using these values, an infant exclusively nursing for 7 hours after a dose would receive about 0.3 mcg of the drug plus metabolite.</p><p>A mother undergoing surgery received a single 6 mg dose of midazolam intravenously for anesthesia induction. Breastmilk concentration of midazolam was 25 mcg/L at 30 minutes after the dose, 12 mcg/L at 1 hour after the dose and 7 mcg/L at 2 hours after the dose. From 4 hours onward the drug was unmeasurable (<5 mcg/L). Hydroxymidazolam was not measured.[<a class="bibr" href="#LM369.REF.8" rid="LM369.REF.8">8</a>]</p><p>Five women who were 6 to 15 weeks postpartum were given a single dose of 2 mg of midazolam intravenously before undergoing general anesthesia with propofol and fentanyl. Several milk samples were collected between 5 and 24 hours after the injection from each woman. The authors estimated that the infants would receive an average of 0.016 mcg/kg in the 24 hours after a single dose of midazolam. This corresponds to 0.06% of the maternal weight-adjusted dosage. Hydroxymidazolam was not measured. The authors concluded that this amount of midazolam in milk is unlikely to affect a healthy, term infant.[<a class="bibr" href="#LM369.REF.6" rid="LM369.REF.6">6</a>,<a class="bibr" href="#LM369.REF.9" rid="LM369.REF.9">9</a>] The infants of mothers not undergoing a surgical procedure might receive a greater dose of midazolam in breastmilk, but it would be unlikely to be a large dose.</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM369.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>In a telephone follow-up study, 124 mothers who took a benzodiazepine while nursing reported whether their infants had any signs of sedation. Nineteen mothers took midazolam (presumably orally) while breastfeeding and none reported sedation in her infant.[<a class="bibr" href="#LM369.REF.10" rid="LM369.REF.10">10</a>]</p></div><div id="LM369.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Five women who were 6 to 15 weeks postpartum were given single doses of 2 mg of midazolam and 2.5 mg/kg of propofol intravenously before undergoing general anesthesia. The women's milk output following the surgical procedure was less than half of the normal milk output of nursing mothers. The authors speculated that milk volume might be reduced postoperatively because of perioperative fluid restriction and volume losses, as well as stress-induced inhibition of milk production.[<a class="bibr" href="#LM369.REF.6" rid="LM369.REF.6">6</a>]</p></div><div id="LM369.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p>(Intravenous Sedation) <a href="/books/n/lactmed/LM1299/?report=reader">Dexmedetomidine</a>, <a href="/books/n/lactmed/LM427/?report=reader">Etomidate</a>, <a href="/books/n/lactmed/LM426/?report=reader">Methohexital</a>, <a href="/books/n/lactmed/LM425/?report=reader">Propofol</a>; (Oral for Sleep) <a href="/books/n/lactmed/LM395/?report=reader">Zaleplon</a>, <a href="/books/n/lactmed/LM396/?report=reader">Zolpidem</a></p></div><div id="LM369.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="LM369.REF.1">Uguz
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F.
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A new safety scoring system for the use of psychotropic drugs during lactation.
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Am J Ther
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2021;28:e118-e26.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/30601177" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 30601177</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="LM369.REF.2">Shergill
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AK, Ben-Menachem
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T, Chandrasekhara
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V, et al.
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Guidelines for endoscopy in pregnant and lactating women.
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Gastrointest Endosc
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2012;76:18-24.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/22579258" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 22579258</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="LM369.REF.3">Vargo
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JJ, Delegge
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MH, Feld
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AD, et al.
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Multisociety sedation curriculum for gastrointestinal endoscopy.
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Gastroenterology
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2012;143:e18-41.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/22624720" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 22624720</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>4.</dt><dd><div class="bk_ref" id="LM369.REF.4">Lee
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JJ, Rubin
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AP. Breast feeding and anaesthesia.
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Anaesthesia
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1993;48:616-25.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/8346780" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 8346780</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>5.</dt><dd><div class="bk_ref" id="LM369.REF.5">Spigset
|
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O.
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Anaesthetic agents and excretion in breast milk.
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Acta Anaesthesiol Scand
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1994;38:94-103.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/8171959" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 8171959</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>6.</dt><dd><div class="bk_ref" id="LM369.REF.6">Nitsun
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M, Szokol
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JW, Saleh
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HJ, et al.
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Pharmacokinetics of midazolam, propofol, and fentanyl transfer to human breast milk.
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Clin Pharmacol Ther
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2006;79:549-57.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/16765143" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16765143</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>7.</dt><dd><div class="bk_ref" id="LM369.REF.7">Matheson
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I, Lunde
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PKM, Bredesen
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JE. Midazolam and nitrazepam in the maternity ward: Milk concentrations and clinical effects.
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Br J Clin Pharmacol
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1990;30:787-93.
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[<a href="/pmc/articles/PMC1368298/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC1368298</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/2288825" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 2288825</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>8.</dt><dd><div class="bk_ref" id="LM369.REF.8">Koitabashi
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T, Satoh
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N, Takino
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Y. Intravenous midazolam passage into breast milk.
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J Anesth
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1997;11:242-3.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/28921122" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28921122</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>9.</dt><dd><div class="bk_ref" id="LM369.REF.9">Avram
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MJ, Nitsun
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M, Szokol
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JW, et al.
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Midazolam elimination in human breast milk.
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Clin Pharmacol Ther
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2006;79 (Suppl. S):P7. doi:10.1016/j.clpt.2005.12.021 [<a href="https://pubmed.ncbi.nlm.nih.gov/16765143" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16765143</span></a>] [<a href="http://dx.crossref.org/10.1016/j.clpt.2005.12.021" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">CrossRef</a>]</div></dd></dl><dl class="bkr_refwrap"><dt>10.</dt><dd><div class="bk_ref" id="LM369.REF.10">Kelly
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LE, Poon
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S, Madadi
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P, et al.
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Neonatal benzodiazepines exposure during breastfeeding.
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J Pediatr
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2012;161:448-51.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/22504099" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 22504099</span></a>]</div></dd></dl></dl></div></div><div id="LM369.Substance_Identification"><h2 id="_LM369_Substance_Identification_">Substance Identification</h2><div id="LM369.Substance_Name"><h3>Substance Name</h3><p>Midazolam</p></div><div id="LM369.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>59467-70-8</p></div><div id="LM369.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Anticonvulsants</p><p>Hypnotics and Sedatives</p><p>Anti-Anxiety Agents</p><p>Benzodiazepines</p><p>Anesthetics, Intravenous</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK501235_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">October 15, 2024</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Midazolam. [Updated 2024 Oct 15].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/lactmed/LM368/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/lactmed/LM1319/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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