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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Eszopiclone - Drugs and Lactation Database (LactMed®) - NCBI Bookshelf</title>
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<meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]">
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<meta name="citation_title" content="Eszopiclone">
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<meta name="citation_publisher" content="National Institute of Child Health and Human Development">
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<meta name="citation_date" content="2024/10/15">
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<meta name="citation_keywords" content="Eszopiclone">
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<meta name="citation_keywords" content="Lunesta">
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<meta name="citation_keywords" content="Estorra">
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<meta name="citation_keywords" content="(S)-Zopiclone">
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<meta name="citation_keywords" content="(S)-Eszopiclone">
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<meta name="citation_keywords" content="UNII-UZX80K71OE">
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<meta name="citation_keywords" content="SEP-190">
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<meta name="citation_keywords" content="UZX80K71OE">
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<meta name="citation_keywords" content="HSDB 7472">
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<meta name="citation_keywords" content="DEA No. 2784">
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<meta name="citation_keywords" content="8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine">
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<meta name="description" content="No data are available on the use of eszopiclone during breastfeeding. Data from the racemate, zopiclone, indicate that occasional use while breastfeeding an older infant should pose little risk to the infant. A safety scoring system finds zopiclone possible to use during breastfeeding,[1] but the infant should be monitored for sedation, poor feeding and poor weight gain.[2] An alternate hypnotic may be preferred, especially while nursing a newborn or preterm infant.">
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<meta name="og:description" content="No data are available on the use of eszopiclone during breastfeeding. Data from the racemate, zopiclone, indicate that occasional use while breastfeeding an older infant should pose little risk to the infant. A safety scoring system finds zopiclone possible to use during breastfeeding,[1] but the infant should be monitored for sedation, poor feeding and poor weight gain.[2] An alternate hypnotic may be preferred, especially while nursing a newborn or preterm infant.">
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class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK501218_"><span class="title" itemprop="name">Eszopiclone</span></h1><p class="fm-aai"><a href="#_NBK501218_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 2 minutes</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><p>CASRN: 138729-47-2</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/135114014" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=135114014" alt="image 135114014 in the ncbi pubchem database" /></a><div id="LM352.Drug_Levels_and_Effects"><h2 id="_LM352_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM352.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>No data are available on the use of eszopiclone during breastfeeding. Data from the racemate, zopiclone, indicate that occasional use while breastfeeding an older infant should pose little risk to the infant. A safety scoring system finds zopiclone possible to use during breastfeeding,[<a class="bibr" href="#LM352.REF.1" rid="LM352.REF.1">1</a>] but the infant should be monitored for sedation, poor feeding and poor weight gain.[<a class="bibr" href="#LM352.REF.2" rid="LM352.REF.2">2</a>] An alternate hypnotic may be preferred, especially while nursing a newborn or preterm infant.</p></div><div id="LM352.Drug_Levels"><h3>Drug Levels</h3><p>Eszopiclone is the S-isomer of zopiclone which is a racemic mixture containing 50% S- and 50% R-eszopiclone. In the United States, the recommended dose of eszopiclone is 2 mg compared with the dose of 7.5 mg of zopiclone used in Europe.</p><p><i>Maternal Levels.</i> Three nursing women (time postpartum not stated) received a single oral dose of zopiclone 7.5 mg. Peak milk levels of about 55 mcg/L occurred about 2 hours after the dose. The half-life in milk was similar to that in plasma which was 5.3 hours in healthy adults.[<a class="bibr" href="#LM352.REF.3" rid="LM352.REF.3">3</a>,<a class="bibr" href="#LM352.REF.4" rid="LM352.REF.4">4</a>]</p><p>Twelve nursing mothers who were 2 to 6 days postpartum were given a single oral dose of 7.5 mg of zopiclone. The peak milk level averaged 34 mcg/L (range 24 to 57 mcg/L) and it occurred 2.4 hours (range 1 to 6 hours) after the dose. The mean half-life in milk was 5.3 hours (range 3.5 to 8.6 hours). The authors estimated that an exclusively breastfed infant would receive an average of 15 mcg/kg or 1.2 to 1.4% of the maternal weight-adjusted dosage of zopiclone.[<a class="bibr" href="#LM352.REF.2" rid="LM352.REF.2">2</a>]</p><p>A woman took zopiclone 3.75 mg 4 times daily during pregnancy and postpartum for tension headaches. At 2 weeks postpartum, 2 hours after the second dose of the day, milk zopiclone levels ranged from 2.4 to 47.3 mcg/L and daily zopiclone excretion in the milk was estimated to be 3 mcg for a production of 335 mL. The weight-adjusted maternal dosage was estimated to be 3.2%.[<a class="bibr" href="#LM352.REF.5" rid="LM352.REF.5">5</a>]</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM352.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>In 12 mothers who were 2 to 6 days postpartum and took 7.5 mg of zopiclone, infant breastfeeding was interrupted for 8 to 10 hours before resuming. No unusual effect were noted in the infants.[<a class="bibr" href="#LM352.REF.2" rid="LM352.REF.2">2</a>]</p><p>Thirty-week preterm twins were born to a mother who took zopiclone 3.75 mg 4 times daily for tension headache during pregnancy. They developed withdrawal symptoms during the first week of life. Beginning at 2 weeks of age, they were about two-thirds breastfed by their mother who continued the drug at the same dose. The infants had no clinical abnormalities and were discharged from the hospital 6 weeks after birth.[<a class="bibr" href="#LM352.REF.5" rid="LM352.REF.5">5</a>]</p></div><div id="LM352.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM352.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p><a href="/books/n/lactmed/LM395/?report=reader">Zaleplon</a>, <a href="/books/n/lactmed/LM396/?report=reader">Zolpidem</a></p></div><div id="LM352.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="LM352.REF.1">Uguz
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F.
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A new safety scoring system for the use of psychotropic drugs during lactation.
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Am J Ther
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2021;28:e118-e26.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/30601177" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 30601177</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="LM352.REF.2">Matheson
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I, Sande
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HA, Gaillot
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J. The excretion of zopiclone into breast milk.
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Br J Clin Pharmacol
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1990;30:267-71.
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[<a href="/pmc/articles/PMC1368227/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC1368227</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/2206788" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 2206788</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="LM352.REF.3">Gaillot
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J, Heusse
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D, Hougton
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GW, et al.
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Pharmacokinetics and metabolism of zopiclone.
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Int Pharmacopsychiatry
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1982;17 (Suppl 2):76-91.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/7188377" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 7188377</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>4.</dt><dd><div class="bk_ref" id="LM352.REF.4">Gaillot
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J, Heusse
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D, Hougton
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GW, et al.
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Pharmacokinetics and metabolism of zopiclone.
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Pharmacology
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1983;27 (Suppl 2):76-91.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/6669634" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 6669634</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>5.</dt><dd><div class="bk_ref" id="LM352.REF.5">Mathieu
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O, Masson
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F, Thompson
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MA, et al.
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Case report: In utero exposure and safe breastfeeding in two premature twins of a chronically treated mother with high doses of zopiclone.
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Fundam Clin Pharmacol
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2010;24 (Suppl. S1):424. doi:10.1111/j.1472-8206.2010.00819.x [<a href="http://dx.crossref.org/10.1111/j.1472-8206.2010.00819.x" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">CrossRef</a>]</div></dd></dl></dl></div></div><div id="LM352.Substance_Identification"><h2 id="_LM352_Substance_Identification_">Substance Identification</h2><div id="LM352.Substance_Name"><h3>Substance Name</h3><p>Eszopiclone</p></div><div id="LM352.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>138729-47-2</p></div><div id="LM352.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Hypnotics and Sedatives</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK501218_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">October 15, 2024</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Eszopiclone. [Updated 2024 Oct 15].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/lactmed/LM853/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/lactmed/LM105/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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