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class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK501205_"><span class="title" itemprop="name">Carisoprodol</span></h1><p class="fm-aai"><a href="#_NBK501205_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 2 minutes</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><p>CASRN: 78-44-4</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134970761" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134970761" alt="image 134970761 in the ncbi pubchem database" /></a><div id="LM340.Drug_Levels_and_Effects"><h2 id="_LM340_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM340.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>If carisoprodol is required by the mother, it is not necessarily a reason to discontinue breastfeeding. Slight sedation has occurred in a breastfed newborn infant who was exposed during pregnancy and lactation; sedation might be more pronounced in newborns who are exposed for the first time during nursing. Other agents may be preferred, especially while nursing a newborn or preterm infant, or when other drugs that can cause sedation are used simultaneously.</p></div><div id="LM340.Drug_Levels"><h3>Drug Levels</h3><p>Carisoprodol is metabolized almost entirely to meprobamate which contributes to the overall sedative effect. Carisoprodol has a half-life of 4 hours and meprobamate has a half-life of about 10 hours.[<a class="bibr" href="#LM340.REF.1" rid="LM340.REF.1">1</a>]</p><p><i>Maternal Levels.</i> A mother was taking carisoprodol 700 mg three times daily during pregnancy and lactation. Maternal trough breastmilk levels of carisoprodol and meprobamate were measured before the first morning dose on 4 consecutive days at steady-state (time postpartum not stated). Average minimum breastmilk levels were 0.9 mg/L for carisoprodol and 11.6 mg/L for meprobamate. The authors calculated that the minimum infant dose of the drug plus metabolite was 1.9 mg/kg daily or 4.1% of the maternal weight-adjusted dosage. Extrapolating these results to an average (rather than minimum) dose, the authors estimated that an exclusively breastfed infant would receive 3 mg/kg daily or 6% of the maternal weight-adjusted dosage.[<a class="bibr" href="#LM340.REF.1" rid="LM340.REF.1">1</a>]</p><p>A woman who was suspected to have been abusing carisoprodol had the drug and meprobamate detectable in breastmilk for 2 consecutive days after hospitalization; only meprobamate was detectable on day 3.[<a class="bibr" href="#LM340.REF.2" rid="LM340.REF.2">2</a>]</p><p>A woman took carisoprodol 700 mg orally four times daily at 4- to 6-hour intervals during pregnancy and lactation for spasms of the back muscles. At 1 week postpartum, breastmilk samples were obtained 2 and 3.5 hours after doses of the drug. Two hours after a dose, carisoprodol concentration in milk was 1.4 mg/L and meprobamate was 10.9 mg/L. At 3.5 hours after the following dose, carisoprodol concentration in milk was 0.8 mg/L and meprobamate was 17.1 mg/L. The authors estimated that the maximum intake of carisoprodol plus meprobamate was 2.7 mg/kg daily or 6.9% of the maternal weight-adjusted dosage.[<a class="bibr" href="#LM340.REF.3" rid="LM340.REF.3">3</a>]</p><p><i>Infant Levels.</i> A mother took carisoprodol 700 mg orally four times daily at 4- to 6-hour intervals during pregnancy and lactation. At 1 week postpartum, her exclusively breastfed infant had unmeasurable serum concentrations of carisoprodol (<2 mg/L) and meprobamate (<4 mg/L) 2 hours after nursing (3.5 hours after the mother's previous dose). The investigators hypothesized that either the dose received by the infant was low or the infant's metabolism of the drugs may have been stimulated from the exposure during pregnancy.[<a class="bibr" href="#LM340.REF.3" rid="LM340.REF.3">3</a>]</p></div><div id="LM340.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>A mother taking carisoprodol 700 mg plus propoxyphene 70 mg and acetaminophen 900 mg 3 times daily and partially breastfeeding her infant noticed no unusual behavior or adverse reactions in her infant. The infant grew normally and at 6 months of age, examination by a pediatrician found normal psychomotor development.[<a class="bibr" href="#LM340.REF.1" rid="LM340.REF.1">1</a>]</p><p>A mother took carisoprodol 700 mg orally four times daily at 4- to 6-hour intervals during pregnancy and while exclusively nursing her newborn infant. Slight sedation of the infant was noted during the first month of life.[<a class="bibr" href="#LM340.REF.3" rid="LM340.REF.3">3</a>]</p></div><div id="LM340.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM340.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="LM340.REF.1">Nordeng
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H, Zahlsen
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K, Spigset
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O. Transfer of carisoprodol to breast milk.
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Ther Drug Monit
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2001;23:298-300.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/11360042" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11360042</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="LM340.REF.2">Bailey
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DN, Briggs
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JR. Carisoprodol: An unrecognized drug of abuse.
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Am J Clin Pathol
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2002;117:396-400.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/11888078" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11888078</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="LM340.REF.3">Briggs
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GG, Ambrose
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PJ, Nageotte
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MP, et al.
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High-dose carisoprodol during pregnancy and lactation.
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Ann Pharmacother
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2008;42:898-901.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/18460586" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18460586</span></a>]</div></dd></dl></dl></div></div><div id="LM340.Substance_Identification"><h2 id="_LM340_Substance_Identification_">Substance Identification</h2><div id="LM340.Substance_Name"><h3>Substance Name</h3><p>Carisoprodol</p></div><div id="LM340.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>78-44-4</p></div><div id="LM340.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Muscle Relaxants, Central</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK501205_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">November 15, 2024</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Carisoprodol. [Updated 2024 Nov 15].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/lactmed/LM1182/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/lactmed/LM1338/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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