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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]" /><meta name="citation_title" content="Brompheniramine" /><meta name="citation_publisher" content="National Institute of Child Health and Human Development" /><meta name="citation_date" content="2024/08/15" /><meta name="citation_pmid" content="30000263" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK501204/" /><meta name="citation_keywords" content="Brompheniramine" /><meta name="citation_keywords" content="Brompheniraminum" /><meta name="citation_keywords" content="Parabromdylamine" /><meta name="citation_keywords" content="Bromfeniramina" /><meta name="citation_keywords" content="Ilvin" /><meta name="citation_keywords" content="UNII-H57G17P2FN" /><meta name="citation_keywords" content="HSDB 3017" /><meta name="citation_keywords" content="EINECS 201-657-8" /><meta name="citation_keywords" content="H57G17P2FN" /><meta name="citation_keywords" content="3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Brompheniramine" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Child Health and Human Development" /><meta name="DC.Date" content="2024/08/15" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK501204/" /><meta name="description" content="Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives." /><meta name="og:title" content="Brompheniramine" /><meta name="og:type" content="book" /><meta name="og:description" content="Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK501204/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-lactmed-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/lactmed/LM34/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK501204/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK501204_"><span class="title" itemprop="name">Brompheniramine</span></h1><p class="small">Last Revision: <span itemprop="dateModified">August 15, 2024</span>.</p><p><em>Estimated reading time: 1 minute</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 86-22-6</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134970780" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134970780" alt="image 134970780 in the ncbi pubchem database" /></a><div id="LM34.Drug_Levels_and_Effects"><h2 id="_LM34_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM34.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.</p></div><div id="LM34.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Relevant published information was not found as of the revision date.</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM34.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine).[<a class="bk_pop" href="#LM34.REF.1">1</a>] These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.</p><p>In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.[<a class="bk_pop" href="#LM34.REF.2">2</a>]</p></div><div id="LM34.Effects_on_Lactation_and_Breastmilk"><h3>Effects on Lactation and Breastmilk</h3><p>Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[<a class="bk_pop" href="#LM34.REF.3">3</a>,<a class="bk_pop" href="#LM34.REF.4">4</a>] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[<a class="bk_pop" href="#LM34.REF.3">3</a>] Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.</p></div><div id="LM34.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p><a href="/books/n/lactmed/LM82/">Desloratadine</a>, <a href="/books/n/lactmed/LM111/">Fexofenadine</a>, <a href="/books/n/lactmed/LM163/">Loratadine</a></p></div><div id="LM34.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="LM34.REF.1">Mortimer
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EA, Jr. Drug toxicity from breast milk?
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Pediatrics
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1977;60:780-1.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/917668" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 917668</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="LM34.REF.2">Ito
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S, Blajchman
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A, Stephenson
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M, et al.
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Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication.
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Am J Obstet Gynecol
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1993;168:1393-9.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/8498418" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 8498418</span></a>]</div></dd><dt>3.</dt><dd><div class="bk_ref" id="LM34.REF.3">Messinis
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IE, Souvatzoglou
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A, Fais
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N, et al.
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Histamine H1 receptor participation in the control of prolactin secretion in postpartum.
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J Endocrinol Invest
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1985;8:143-6.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/3928731" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 3928731</span></a>]</div></dd><dt>4.</dt><dd><div class="bk_ref" id="LM34.REF.4">Pontiroli
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AE, De Castro e Silva
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E, Mazzoleni
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F, et al.
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The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: Sex differences and the role of stress.
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J Clin Endocrinol Metab
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1981;52:924-8.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/7228996" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 7228996</span></a>]</div></dd></dl></div></div><div id="LM34.Substance_Identification"><h2 id="_LM34_Substance_Identification_">Substance Identification</h2><div id="LM34.Substance_Name"><h3>Substance Name</h3><p>Brompheniramine</p></div><div id="LM34.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>86-22-6</p></div><div id="LM34.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Antihistamines</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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