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<meta name="citation_title" content="Metipranolol">
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<meta name="citation_keywords" content="Trimepranol">
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<meta name="citation_keywords" content="Disorat">
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<meta name="citation_keywords" content="OptiPranolol">
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<meta name="citation_keywords" content="Metipranololum">
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<meta name="citation_keywords" content="Turoptin">
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<meta name="citation_keywords" content="[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]-2,3,6-trimethylphenyl] acetate">
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class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK501155_"><span class="title" itemprop="name">Metipranolol</span></h1><p class="fm-aai"><a href="#_NBK501155_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 2 minutes</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><p>CASRN: 22664-55-7</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134994195" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134994195" alt="image 134994195 in the ncbi pubchem database" /></a><div id="LM295.Drug_Levels_and_Effects"><h2 id="_LM295_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM295.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Based on its physicochemical properties and its ophthalmic route of administration, metipranolol eye drops would not be expected to cause any adverse effects in breastfed infants. Some guidelines state that gel formulations are preferred over solutions.[<a class="bibr" href="#LM295.REF.1" rid="LM295.REF.1">1</a>,<a class="bibr" href="#LM295.REF.2" rid="LM295.REF.2">2</a>] To substantially diminish the amount of drug that reaches the breastmilk after using eye drops, place pressure over the tear duct by the corner of the eye for 1 minute or more, then remove the excess solution with an absorbent tissue.</p></div><div id="LM295.Drug_Levels"><h3>Drug Levels</h3><p>The excretion of beta-adrenergic blocking drugs into breastmilk is largely determined by their protein binding. Those with low binding are more extensively excreted into breastmilk.[<a class="bibr" href="#LM295.REF.3" rid="LM295.REF.3">3</a>] Accumulation of the drugs in the infant is related to the fraction excreted in urine. With 70% protein binding, 10% renal excretion and a moderately short half-life, metipranolol presents moderately low risk for accumulation in infants.</p><p><i>Maternal Levels.</i> Relevant published information was not found as of the revision date.</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM295.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information on metipranolol was not found as of the revision date. A study of mothers taking beta-blockers during nursing found a numerically, but not statistically significant increased number of adverse reactions in those taking any beta-blocker. Although the ages of infants were matched to control infants, the ages of the affected infants were not stated. None of the mothers were taking metipranolol.[<a class="bibr" href="#LM295.REF.4" rid="LM295.REF.4">4</a>]</p></div><div id="LM295.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information on the effects of beta-blockade or metipranolol during normal lactation was not found as of the revision date. A study in 6 patients with hyperprolactinemia and galactorrhea found no changes in serum prolactin levels following beta-adrenergic blockade with propranolol.[<a class="bibr" href="#LM295.REF.5" rid="LM295.REF.5">5</a>]</p></div><div id="LM295.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p>(Ophthalmic) <a href="/books/n/lactmed/LM292/?report=reader">Levobunolol</a>, <a href="/books/n/lactmed/LM305/?report=reader">Timolol</a></p></div><div id="LM295.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="LM295.REF.1">Blumen-Ohana
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E, Sellem
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E.
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Pregnancy & glaucoma: SFO-SFG recommendations.
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J Fr Ophtalmol
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2020;43:63-6.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/31813552" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 31813552</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="LM295.REF.2">Belkin
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A, Chen
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T, DeOliveria
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AR, et al.
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A practical guide to the pregnant and breastfeeding patient with glaucoma.
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Ophthalmol Glaucoma
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2020;3:79-89.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/32672600" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 32672600</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="LM295.REF.3">Riant
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P, Urien
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S, Albengres
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E, et al.
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High plasma protein binding as a parameter in the selection of betablockers for lactating women.
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Biochem Pharmacol
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1986;35:4579-81.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/2878668" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 2878668</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>4.</dt><dd><div class="bk_ref" id="LM295.REF.4">Ho
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TK, Moretti
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ME, Schaeffer
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JK, et al.
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Maternal beta-blocker usage and breast feeding in the neonate.
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Pediatr Res
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1999;45 (4, pt. 2):67A. doi:10.1203/00006450-199904020-00402 [<a href="http://dx.crossref.org/10.1203/00006450-199904020-00402" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">CrossRef</a>]</div></dd></dl><dl class="bkr_refwrap"><dt>5.</dt><dd><div class="bk_ref" id="LM295.REF.5">Board
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JA, Fierro
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RJ, Wasserman
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AJ, et al.
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Effects of alpha- and beta-adrenergic blocking agents on serum prolactin levels in women with hyperprolactinemia and galactorrhea.
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Am J Obstet Gynecol
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1977;127:285-7.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/556882" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 556882</span></a>]</div></dd></dl></dl></div></div><div id="LM295.Substance_Identification"><h2 id="_LM295_Substance_Identification_">Substance Identification</h2><div id="LM295.Substance_Name"><h3>Substance Name</h3><p>Metipranolol</p></div><div id="LM295.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>22664-55-7</p></div><div id="LM295.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Antihypertensive Agents</p><p>Adrenergic Beta-Antagonists</p><p>Antiglaucoma Agents</p><p>Antiarrhythmics</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK501155_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">October 15, 2024</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Metipranolol. [Updated 2024 Oct 15].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/lactmed/LM180/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/lactmed/LM477/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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