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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK501106_"><span class="title" itemprop="name">Tamoxifen</span></h1><p class="small">Last Revision: <span itemprop="dateModified">July 15, 2024</span>.</p><p><em>Estimated reading time: 2 minutes</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 10540-29-1</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134990041" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134990041" alt="image 134990041 in the ncbi pubchem database" /></a><div id="LM250.Drug_Levels_and_Effects"><h2 id="_LM250_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM250.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Tamoxifen and its active metabolites are detectable in milk and accumulate in milk over time. It can also suppress lactation. If a mother requires treatment with tamoxifen, breastfeeding should be avoided.</p></div><div id="LM250.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> A nursing mother was diagnosed with breast cancer and started on tamoxifen 20 mg daily at 8 am. Thirty-nine milk samples were collected over 23 days before and after tamoxifen initiation. For the first 15 days, two samples were collected each day, one in the afternoon and one in the evening. For the remaining 8 days, only one sample was collected each day. On day 1 of therapy, tamoxifen was detected in a concentration of 16.5 mcg/L at noon and 13.9 mcg/L at 11 pm. Milk concentrations increased steadily to a concentration of 79.5 mcg/L at an unrecorded time on day 23. Seven metabolites were also monitored and increased over the same time period. The two active metabolites, 4-hydroxytamoxifen and Z-endoxifen also increased over time and reached quantifiable levels at day 18. The authors noted that steady-state might not have been attained at the time of the last milk sample.[<a class="bk_pop" href="#LM250.REF.1">1</a>]</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM250.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM250.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Tamoxifen was more effective than placebo in suppressing lactation and preventing engorgement and pain in two trials in postpartum mothers. Neither study stated what, if any, physical methods (e.g., breast binding) were used concurrently.[<a class="bk_pop" href="#LM250.REF.2">2</a>,<a class="bk_pop" href="#LM250.REF.3">3</a>] In one study of 80 women, tamoxifen 10 mg four times daily for 5 days during the first week postpartum was more effective than placebo in suppressing a rise in serum prolactin after use of a mechanical breast pump after 5 days of treatment, but not on day 3. All of the women in the study had breastfed a previous child.[<a class="bk_pop" href="#LM250.REF.2">2</a>] The other study of 150 women used 2 regimens starting within 2 hours of delivery: tamoxifen 30 mg twice daily for 2 days, followed by 10 mg twice daily for 2 days; and 10 mg twice daily for 14 days. More women in the tamoxifen groups had not previously breastfed an infant.[<a class="bk_pop" href="#LM250.REF.3">3</a>]</p><p>In a case report, a woman with a history of breastfeeding 4 children (the last having been weaned 10 months earlier) began lactating after 1 week of a cancer chemotherapy regimen for breast cancer that included tamoxifen 20 mg/day. Milk production continued for several weeks until tamoxifen was discontinued after which it did not return during 12 more weeks of chemotherapy.[<a class="bk_pop" href="#LM250.REF.4">4</a>]</p></div><div id="LM250.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="LM250.REF.1">Peccatori
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FA, Codacci-Pisanelli
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G, Mellgren
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G, et al.
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First-in-human pharmacokinetics of tamoxifen and its metabolites in the milk of a lactating mother: A case study.
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ESMO Open
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2020;5:e000859
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[<a href="/pmc/articles/PMC7594360/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC7594360</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/33115771" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 33115771</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="LM250.REF.2">Masala
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A, Delitala
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G, Lo Dico, G, et al.
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Inhibition of lactation and inhibition of prolactin release after mechanical breast stimulation in puerperal women given tamoxifen or placebo.
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Br J Obstet Gynaecol
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1978;85:134-7.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/626722" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 626722</span></a>]</div></dd><dt>3.</dt><dd><div class="bk_ref" id="LM250.REF.3">Shaaban
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MM. Suppression of lactation by an antiestrogen, tamoxifen.
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Eur J Obstet Gynecol Reprod Biol
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1975;4:167-9
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[<a href="https://pubmed.ncbi.nlm.nih.gov/1053489" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 1053489</span></a>]</div></dd><dt>4.</dt><dd><div class="bk_ref" id="LM250.REF.4">Favis
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GR, Alavi
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JB, Glick
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JH. Lactation from tamoxifen in breast cancer.
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Ann Intern Med
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1979;90:993-4
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[<a href="https://pubmed.ncbi.nlm.nih.gov/220899" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 220899</span></a>]</div></dd></dl></div></div><div id="LM250.Substance_Identification"><h2 id="_LM250_Substance_Identification_">Substance Identification</h2><div id="LM250.Substance_Name"><h3>Substance Name</h3><p>Tamoxifen</p></div><div id="LM250.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>10540-29-1</p></div><div id="LM250.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Antineoplastic Agents</p><p>Estrogen Antagonists</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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