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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]" /><meta name="citation_title" content="Smallpox Vaccine" /><meta name="citation_publisher" content="National Institute of Child Health and Human Development" /><meta name="citation_date" content="2024/07/15" /><meta name="citation_pmid" content="30000158" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK501099/" /><meta name="citation_keywords" content="Dryvax" /><meta name="citation_keywords" content="Jynneos" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Smallpox Vaccine" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Child Health and Human Development" /><meta name="DC.Date" content="2024/07/15" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK501099/" /><meta name="description" content="The Centers for Disease Control and Prevention recommends that nursing mothers not receive the smallpox vaccine, even if they are pumping their milk and feeding it to their infant by bottle feeding. If a woman received smallpox vaccine during pregnancy or breastfeeding, she should avoid breastfeeding and handling any baby for at least 3 to 4 weeks until the vaccination scab has separated from the vaccination site. The breasts can be pumped to maintain the milk supply, but the milk should be discarded.[1] The newer smallpox and monkeypox vaccine is a live, non-replicating vaccine and is not likely to have these problems during breastfeeding." /><meta name="og:title" content="Smallpox Vaccine" /><meta name="og:type" content="book" /><meta name="og:description" content="The Centers for Disease Control and Prevention recommends that nursing mothers not receive the smallpox vaccine, even if they are pumping their milk and feeding it to their infant by bottle feeding. If a woman received smallpox vaccine during pregnancy or breastfeeding, she should avoid breastfeeding and handling any baby for at least 3 to 4 weeks until the vaccination scab has separated from the vaccination site. The breasts can be pumped to maintain the milk supply, but the milk should be discarded.[1] The newer smallpox and monkeypox vaccine is a live, non-replicating vaccine and is not likely to have these problems during breastfeeding." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK501099/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-lactmed-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/lactmed/LM244/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK501099/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK501099_"><span class="title" itemprop="name">Smallpox Vaccine</span></h1><p class="small">Last Revision: <span itemprop="dateModified">July 15, 2024</span>.</p><p><em>Estimated reading time: 1 minute</em></p></div><div class="body-content whole_rhythm" itemprop="text"><div id="LM244.Drug_Levels_and_Effects"><h2 id="_LM244_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM244.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>The Centers for Disease Control and Prevention recommends that nursing mothers not receive the smallpox vaccine, even if they are pumping their milk and feeding it to their infant by bottle feeding. If a woman received smallpox vaccine during pregnancy or breastfeeding, she should avoid breastfeeding and handling any baby for at least 3 to 4 weeks until the vaccination scab has separated from the vaccination site. The breasts can be pumped to maintain the milk supply, but the milk should be discarded.[<a class="bk_pop" href="#LM244.REF.1">1</a>] The newer smallpox and monkeypox vaccine is a live, non-replicating vaccine and is not likely to have these problems during breastfeeding.</p></div><div id="LM244.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Smallpox vaccine has not been studied in lactating women. Live vaccinia virus can be inadvertently transmitted from a lactating mother to her breastfed infant. Infants are at high risk of developing serious complications from live vaccinia smallpox vaccination.[<a class="bk_pop" href="#LM244.REF.2">2</a>]</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM244.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>One 5-month-old breastfed infant acquired a vaccinia lesion on her upper lip, tongue and cheek after her mother developed vaccinia lesions on both areolas. The mother's infection apparently originated from the father who had been vaccinated about 10 days prior. The exact mechanism of transmission was not apparent.[<a class="bk_pop" href="#LM244.REF.3">3</a>]</p></div><div id="LM244.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM244.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p>
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<a href="/books/n/lactmed/monkeypox_vaccine/">Monkeypox Vaccine</a>
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</p></div><div id="LM244.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="LM244.REF.1">Acambis Inc. Medication Guide. ACAM2000 Smallpox (Vaccinia) Vaccine, Live. Version 1.0. 2007</div></dd><dt>2.</dt><dd><div class="bk_ref" id="LM244.REF.2">Acambis Inc. ACAM2000 (Smallpox [Vaccinia] Vaccine, Live) package insert. 2007</div></dd><dt>3.</dt><dd><div class="bk_ref" id="LM244.REF.3">Garde
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V, Harper
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D, Fairchok
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MP. Tertiary contact vaccinia in a breastfeeding infant.
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JAMA
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2004;291:725-7
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[<a href="https://pubmed.ncbi.nlm.nih.gov/14871916" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 14871916</span></a>]</div></dd></dl></div></div><div id="LM244.Substance_Identification"><h2 id="_LM244_Substance_Identification_">Substance Identification</h2><div id="LM244.Substance_Name"><h3>Substance Name</h3><p>Smallpox Vaccine</p></div><div id="LM244.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Vaccines</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div><div class="small"><span class="label">Bookshelf ID: NBK501099</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/30000158" title="PubMed record of this page" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">30000158</a></span></div><div style="margin-top:2em" class="bk_noprnt"><a class="bk_cntns" href="/books/n/lactmed/">Contents</a><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/lactmed/LM748/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/lactmed/LM1129/" title="Next page in this title">Next ></a></div></div></div></div>
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