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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK501093_"><span class="title" itemprop="name">Reserpine</span></h1><p class="small">Last Revision: <span itemprop="dateModified">November 15, 2024</span>.</p><p><em>Estimated reading time: 1 minute</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 50-55-5</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134971500" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134971500" alt="image 134971500 in the ncbi pubchem database" /></a><div id="LM239.Drug_Levels_and_Effects"><h2 id="_LM239_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM239.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Because no information is available on the use of reserpine during breastfeeding and it might adversely affect the breastfed infant, an alternate drug is preferred, especially while nursing a newborn or preterm infant.</p></div><div id="LM239.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Relevant published information was not found as of the revision date.</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM239.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Although not well documented, reserpine is said to cause nasal stuffiness and increased tracheobronchial secretions in breastfed infants.[<a class="bk_pop" href="#LM239.REF.1">1</a>]</p></div><div id="LM239.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Reserpine has reportedly caused galactorrhea and has been used to increase breastmilk production, although it is obsolete for this use.[<a class="bk_pop" href="#LM239.REF.2">2</a>-<a class="bk_pop" href="#LM239.REF.4">4</a>]</p></div><div id="LM239.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p><a href="/books/n/lactmed/LM727/">Candesartan</a>, <a href="/books/n/lactmed/LM26/">Benazepril</a>, <a href="/books/n/lactmed/LM38/">Captopril</a>, <a href="/books/n/lactmed/LM102/">Enalapril</a>, <a href="/books/n/lactmed/LM160/">Lisinopril</a>, <a href="/books/n/lactmed/LM234/">Quinapril</a>, <a href="/books/n/lactmed/LM179/">Methyldopa</a>, <a href="/books/n/lactmed/LM198/">Nifedipine</a>, <a href="/books/n/lactmed/LM301/">Propranolol</a></p></div><div id="LM239.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="LM239.REF.1">Knowles
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JA. Drugs in milk.
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Pediatr Currents Ross Laboratories
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1972;21:28-32</div></dd><dt>2.</dt><dd><div class="bk_ref" id="LM239.REF.2">Vaidya
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RA, Vaidya
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AB, Van Woert
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MH, et al.
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Galactorrhea and Parkinson-like syndrome: An adverse effect of alpha-methyldopa.
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Metabolism
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1970;19:1068-70
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[<a href="https://pubmed.ncbi.nlm.nih.gov/4923681" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 4923681</span></a>]</div></dd><dt>3.</dt><dd><div class="bk_ref" id="LM239.REF.3">Mazhbits
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IA. Use of reserpine as a lactogenic substance.
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Akush Ginekol (Mosk)
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1970;46:70-2
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[<a href="https://pubmed.ncbi.nlm.nih.gov/5433043" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 5433043</span></a>]</div></dd><dt>4.</dt><dd><div class="bk_ref" id="LM239.REF.4">Somlyo
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AP, Wayde
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JD. Abnormal lactation. Report of a case induced by reserpine and a brief review of the subject.
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J Mt Sinai Hosp N Y
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1960;27:5-9
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[<a href="https://pubmed.ncbi.nlm.nih.gov/13832752" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 13832752</span></a>]</div></dd></dl></div></div><div id="LM239.Substance_Identification"><h2 id="_LM239_Substance_Identification_">Substance Identification</h2><div id="LM239.Substance_Name"><h3>Substance Name</h3><p>Reserpine</p></div><div id="LM239.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>50-55-5</p></div><div id="LM239.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Antihypertensive Agents</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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