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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Penicillin V - Drugs and Lactation Database (LactMed®) - NCBI Bookshelf</title>
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<meta name="citation_title" content="Penicillin V">
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<meta name="citation_keywords" content="Oracillin">
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<meta name="citation_keywords" content="Phenomycilline">
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<meta name="citation_keywords" content="Phenopenicillin">
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<meta name="citation_keywords" content="Beromycin">
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<meta name="citation_keywords" content="Fenospen">
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<meta name="citation_keywords" content="Phenoxymethylpenicillin">
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<meta name="citation_keywords" content="Meropenin">
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<meta name="citation_keywords" content="Phenocillin">
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<meta name="citation_keywords" content="Stabicillin">
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<meta name="citation_keywords" content="Vebecillin">
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<meta name="citation_keywords" content="Fenacilin">
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<meta name="citation_keywords" content="Fenoxypen">
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<meta name="citation_keywords" content="Penicillin phenoxymethyl">
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<meta name="citation_keywords" content="Calcipen">
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<meta name="citation_keywords" content="V-Cillin">
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<meta name="citation_keywords" content="Oratren">
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<meta name="citation_keywords" content="Rocilin">
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<meta name="citation_keywords" content="Apopen">
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<meta name="citation_keywords" content="Ospen">
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<meta name="citation_keywords" content="Compocillin V">
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<meta name="citation_keywords" content="Distaquaine V">
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<meta name="citation_keywords" content="Eskacillian V">
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<meta name="citation_keywords" content="Eskacillin V">
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<meta name="citation_keywords" content="Crystapen V">
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<meta name="citation_keywords" content="V-Tablopen">
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<meta name="citation_keywords" content="Fenoximetilpenicilina">
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<meta name="citation_keywords" content="Pen-vee">
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<meta name="citation_keywords" content="Acipen V">
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<meta name="citation_keywords" content="Pen-Oral">
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<meta name="citation_keywords" content="V-Cylina">
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<meta name="citation_keywords" content="V-Cyline">
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<meta name="citation_keywords" content="Phenoxymethyl penicillin">
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<meta name="citation_keywords" content="P-Mega-Tablinen">
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<meta name="citation_keywords" content="Phenoxymethylpenicilline">
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<meta name="citation_keywords" content="Pen-V">
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<meta name="citation_keywords" content="V-Cil">
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<meta name="citation_keywords" content="Phenoximethylpenicillinum">
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<meta name="citation_keywords" content="Phenoxymethylpenicillinum">
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<meta name="citation_keywords" content="Fenossimetilpenicillina">
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<meta name="citation_keywords" content="phenoxymethylpenicillinic acid">
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<meta name="citation_keywords" content="Phenoxymethylenepenicillinic acid">
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<meta name="citation_keywords" content="Fenossimetilpenicillina [DCIT]">
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<meta name="citation_keywords" content="6-Phenoxyacetamidopenicillanic acid">
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<meta name="citation_keywords" content="Fenoximetilpenicilina [INN-Spanish]">
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<meta name="citation_keywords" content="CCRIS 752">
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<meta name="citation_keywords" content="UNII-Z61I075U2W">
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<meta name="citation_keywords" content="Penicillin V [USAN:USP]">
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<meta name="citation_keywords" content="HSDB 6314">
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<meta name="citation_keywords" content="Phenoxymethylpenicilline [INN-French]">
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<meta name="citation_keywords" content="Phenoxymethylpenicillinum [INN-Latin]">
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<meta name="citation_keywords" content="Phenoxymethylpenicillin [INN]">
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<meta name="citation_keywords" content="87-08-1">
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<meta name="citation_keywords" content="BRN 0096259">
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<meta name="citation_keywords" content="Penicillanic acid, 6-phenoxyacetamido-">
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<meta name="citation_keywords" content="4-27-00-05884 (Beilstein Handbook Reference)">
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<meta name="citation_keywords" content="(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenoxyacetamido)-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid">
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<meta name="citation_keywords" content="3,3-Dimethyl-7-oxo-6-((phenyloxyacetyl)amino)-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid">
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<meta name="citation_keywords" content="4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((phenoxyacetyl)amino)-, (2S-(2alpha,5alpha,6beta))-">
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<meta name="citation_keywords" content="4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-(2-phenoxyacetamido)-">
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<meta name="citation_keywords" content="4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((phenoxyacetyl)amino)-, (2S,5R,6R)-">
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<meta name="DC.Title" content="Penicillin V">
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<meta name="description" content="Limited information indicates that penicillin V produces low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with penicillins, but these effects have not been adequately evaluated. Penicillin V is acceptable in nursing mothers.">
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<meta name="og:description" content="Limited information indicates that penicillin V produces low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with penicillins, but these effects have not been adequately evaluated. Penicillin V is acceptable in nursing mothers.">
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class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK501062_"><span class="title" itemprop="name">Penicillin V</span></h1><p class="fm-aai"><a href="#_NBK501062_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 1 minute</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><p>CASRN: 87-08-1</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134971429" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134971429" alt="image 134971429 in the ncbi pubchem database" /></a><div id="LM210.Drug_Levels_and_Effects"><h2 id="_LM210_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM210.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Limited information indicates that penicillin V produces low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with penicillins, but these effects have not been adequately evaluated. Penicillin V is acceptable in nursing mothers.</p></div><div id="LM210.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Milk penicillin V levels were measured in 16 women after an oral dose of 1320 mg. In 7 women with mastitis, peak milk levels averaged 0.72 mg/L in the breast with mastitis and 0.58 mg/L without mastitis. In 4 women without mastitis (control), peak milk levels averaged 0.3 mg/L. Differences in the levels in mastitic milk and control milk were statistically significantly from nonmastitic milk in the women with mastitis in the opposite breast. In the women with mastitis, the peak level occurred 2.6 to 2.7 hours after the dose; in the women without mastitis, the peak occurred 5.4 hours after the dose. The average milk concentration and areas under the curve were greater in the women with mastitis, but the differences were not statistically significant. The authors estimated that an exclusively breastfed infant would receive an average daily dosage of about 50 mcg/kg (range 20 to 90 mcg/kg).[<a class="bibr" href="#LM210.REF.1" rid="LM210.REF.1">1</a>]</p><p><i>Infant Levels.</i> Nursing mothers were given a single oral dose of 1320 mg of penicillin V. In two of the infants who were breastfed, urine penicillin V was measured 2 hours after nursing. In one it was undetectable and in the other, the urine concentration was 520 mcg/L.[<a class="bibr" href="#LM210.REF.1" rid="LM210.REF.1">1</a>]</p></div><div id="LM210.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>In one study, 12 infants were breastfed during maternal penicillin V therapy. Seven appeared normal, 3 had looser stools than normal, and 1 had a rash on the buttocks on the last day of therapy. These effects were possibly related to penicillin V in milk, but no control group was present. One infant had stains of blood in the stool, but it had happened once prior to maternal penicillin V treatment.[<a class="bibr" href="#LM210.REF.1" rid="LM210.REF.1">1</a>]</p></div><div id="LM210.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM210.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="LM210.REF.1">Matheson I, Samseth M, Loberg R, et al. Milk transfer of phenoxymethylpenicillin during puerperal mastitis. <span><span class="ref-journal">Br J Clin Pharmacol. </span>1988;<span class="ref-vol">25</span>:33–40.</span> [<a href="/pmc/articles/PMC1386612/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC1386612</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/3130891" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 3130891</span></a>]</div></dd></dl></dl></div></div><div id="LM210.Substance_Identification"><h2 id="_LM210_Substance_Identification_">Substance Identification</h2><div id="LM210.Substance_Name"><h3>Substance Name</h3><p>Penicillin V</p></div><div id="LM210.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>87-08-1</p></div><div id="LM210.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Anti-Infective Agents</p><p>Antibacterial Agents</p><p>Penicillins</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK501062_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">February 15, 2021</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Penicillin V. [Updated 2021 Feb 15].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/lactmed/LM209/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/lactmed/LM380/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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