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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Ofloxacin - Drugs and Lactation Database (LactMed®) - NCBI Bookshelf</title>
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<meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]">
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<meta name="citation_title" content="Ofloxacin">
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<meta name="citation_publisher" content="National Institute of Child Health and Human Development">
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<meta name="citation_date" content="2025/01/15">
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<meta name="citation_pmid" content="30000114">
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<meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK501055/">
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<meta name="citation_keywords" content="ofloxacin">
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<meta name="citation_keywords" content="Ofloxacine">
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<meta name="citation_keywords" content="Floxin">
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<meta name="citation_keywords" content="Oxaldin">
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<meta name="citation_keywords" content="Tarivid">
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<meta name="citation_keywords" content="Ofloxacinum">
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<meta name="citation_keywords" content="Ofloxacino">
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<meta name="citation_keywords" content="Ocuflox">
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<meta name="citation_keywords" content="Oflocet">
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<meta name="citation_keywords" content="Visiren">
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<meta name="citation_keywords" content="Ofloxacina">
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<meta name="citation_keywords" content="Floxin otic">
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<meta name="citation_keywords" content="DL-8280">
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<meta name="citation_keywords" content="HSDB 8030">
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<meta name="citation_keywords" content="BRN 36579477-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid">
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<meta name="DC.Title" content="Ofloxacin">
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<meta name="DC.Date" content="2025/01/15">
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<meta name="description" content="Ofloxacin appears in breastmilk in low levels. Fluoroquinolones have traditionally not been used in infants because of concern about adverse effects on the infants' developing joints. However, recent studies indicate little risk.[1,2] The calcium in milk might prevent absorption of the small amounts of fluoroquinolones in milk.[3] Insufficient data exist to prove or disprove this assertion. Developmental problems have been reported in two infants exposed to ofloxacin in breastmilk, but their mothers were also exposed to several drugs during pregnancy and during breastfeeding, so the problems cannot necessarily be attributed to ofloxacin. Use of ofloxacin is acceptable in nursing mothers with monitoring of the infant for possible effects on the flora, such as diarrhea or candidiasis (thrush, diaper rash). Avoiding breastfeeding for 4 to 6 hours after a dose should decrease the exposure of the infant to ofloxacin in breastmilk.">
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<meta name="og:description" content="Ofloxacin appears in breastmilk in low levels. Fluoroquinolones have traditionally not been used in infants because of concern about adverse effects on the infants' developing joints. However, recent studies indicate little risk.[1,2] The calcium in milk might prevent absorption of the small amounts of fluoroquinolones in milk.[3] Insufficient data exist to prove or disprove this assertion. Developmental problems have been reported in two infants exposed to ofloxacin in breastmilk, but their mothers were also exposed to several drugs during pregnancy and during breastfeeding, so the problems cannot necessarily be attributed to ofloxacin. Use of ofloxacin is acceptable in nursing mothers with monitoring of the infant for possible effects on the flora, such as diarrhea or candidiasis (thrush, diaper rash). Avoiding breastfeeding for 4 to 6 hours after a dose should decrease the exposure of the infant to ofloxacin in breastmilk.">
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class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK501055_"><span class="title" itemprop="name">Ofloxacin</span></h1><p class="fm-aai"><a href="#_NBK501055_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 2 minutes</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><p>CASRN: 82419-36-1</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/135013562" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=135013562" alt="image 135013562 in the ncbi pubchem database" /></a><div id="LM204.Drug_Levels_and_Effects"><h2 id="_LM204_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM204.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Ofloxacin appears in breastmilk in low levels. Fluoroquinolones have traditionally not been used in infants because of concern about adverse effects on the infants' developing joints. However, recent studies indicate little risk.[<a class="bibr" href="#LM204.REF.1" rid="LM204.REF.1">1</a>,<a class="bibr" href="#LM204.REF.2" rid="LM204.REF.2">2</a>] The calcium in milk might prevent absorption of the small amounts of fluoroquinolones in milk.[<a class="bibr" href="#LM204.REF.3" rid="LM204.REF.3">3</a>] Insufficient data exist to prove or disprove this assertion. Developmental problems have been reported in two infants exposed to ofloxacin in breastmilk, but their mothers were also exposed to several drugs during pregnancy and during breastfeeding, so the problems cannot necessarily be attributed to ofloxacin. Use of ofloxacin is acceptable in nursing mothers with monitoring of the infant for possible effects on the flora, such as diarrhea or candidiasis (thrush, diaper rash). Avoiding breastfeeding for 4 to 6 hours after a dose should decrease the exposure of the infant to ofloxacin in breastmilk.</p><p>Maternal use of an ear drop or eye drop that contains ofloxacin presents negligible risk for the nursing infant. To substantially diminish the amount of drug that reaches the breastmilk after using eye drops, place pressure over the tear duct by the corner of the eye for 1 minute or more, then remove the excess solution with an absorbent tissue.</p></div><div id="LM204.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Ten lactating women (time postpartum not stated) were given ofloxacin 400 mg orally every 12 hours for 3 doses. Milk ofloxacin was measured after the third dose. The highest levels averaging 2.41 mg/L occurred 2 hours after the dose. Average milk levels then fell as follows: 1.91 mg/L at 4 hours; 1.25 mg/L at 6 hours; 0.64 mg/L at 9 hours; 0.29 mg/L at 12 hours; and 0.05 mg/L at 24 hours after the dose.[<a class="bibr" href="#LM204.REF.4" rid="LM204.REF.4">4</a>] Using the peak milk level data from this study, an exclusively breastfed infant would receive an estimated maximum of 0.36 mg/kg daily with this maternal dosage regimen.</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM204.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Ofloxacin was used as part of multidrug regimens to treat two pregnant women with multidrug-resistant tuberculosis, one throughout pregnancy and postpartum and the other postpartum only. The infants were breastfed (extent and duration not stated). At age 4.6 and 5.1 years, the children were developing normally except for a mild speech delay in one and hyperactivity in the other.[<a class="bibr" href="#LM204.REF.5" rid="LM204.REF.5">5</a>]</p></div><div id="LM204.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM204.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p>(Systemic, Ophthalmic) Ciprofloxacin, <a href="/books/n/lactmed/LM157/?report=reader">Levofloxacin</a></p></div><div id="LM204.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="LM204.REF.1">Gürpinar
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AN, Balkan
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E, Kiliç
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N, et al.
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The effects of a fluoroquinolone on the growth and development of infants.
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J Int Med Res
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1997;25:302-6
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[<a href="https://pubmed.ncbi.nlm.nih.gov/9364293" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9364293</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="LM204.REF.2">van den Oever
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HL, Versteegh
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FG, Thewessen
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EA, et al.
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Ciprofloxacin in preterm neonates: Case report and review of the literature.
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Eur J Pediatr
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1998;157:843-5
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[<a href="https://pubmed.ncbi.nlm.nih.gov/9809826" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9809826</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="LM204.REF.3">Fleiss
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PM. The effect of maternal medications on breast-feeding infants.
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J Hum Lact
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1992;8:7
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[<a href="https://pubmed.ncbi.nlm.nih.gov/1558663" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 1558663</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>4.</dt><dd><div class="bk_ref" id="LM204.REF.4">Giamarellou
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H, Kolokythas
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E, Petrikkos
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G, et al.
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Pharmacokinetics of three newer quinolones in pregnant and lactating women.
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Am J Med
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1989;87 (Suppl 5A):49S-51S
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[<a href="https://pubmed.ncbi.nlm.nih.gov/2589384" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 2589384</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>5.</dt><dd><div class="bk_ref" id="LM204.REF.5">Drobac
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PC, del Castillo
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H, Sweetland
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A, et al.
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Treatment of multidrug-resistant tuberculosis during pregnancy: Long-term follow-up of 6 children with intrauterine exposure to second-line agents.
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Clin Infect Dis
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2005;40:1689-92
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[<a href="https://pubmed.ncbi.nlm.nih.gov/15889370" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15889370</span></a>]</div></dd></dl></dl></div></div><div id="LM204.Substance_Identification"><h2 id="_LM204_Substance_Identification_">Substance Identification</h2><div id="LM204.Substance_Name"><h3>Substance Name</h3><p>Ofloxacin</p></div><div id="LM204.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>82419-36-1</p></div><div id="LM204.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Anti-Infective Agents</p><p>Antibacterial Agents</p><p>Quinolones</p><p>Fluoroquinolones</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK501055_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">January 15, 2025</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Ofloxacin. [Updated 2025 Jan 15].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/lactmed/LM1023/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/lactmed/LM205/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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